Browsing by Author "XX609648"

Now showing items 1-20 of 63

    • A molecular reporter for monitoring autophagic flux in nervous system in vivo 
      Castillo, K.; Valenzuela, V.; Oñate, M.; Hetz Flores, Claudio (Elsevier, 2017)
      The relevance of autophagy in neuronal health has been extensively reported in a plethora of conditions affecting the nervous system, such as neurodegenerative diseases, cancer, diabetes, and tissue injury, where altered ...
    • Activation of the unfolded protein response enhances motor recovery after spinal cord injury 
      Valenzuela, V.; Collyer, E.; Armentano, D.; Parsons, G. B.; Court, F. A.; Hetz Flores, Claudio (NATURE PUBLISHING GROUP, 2012-02)
      Spinal cord injury (SCI) is a major cause of paralysis, and involves multiple cellular and tissular responses including demyelination, inflammation, cell death and axonal degeneration. Recent evidence suggests that ...
    • Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury 
      Oñate, Martiza; Catenaccio, Alejandra; Martínez, Gabriela; Armentano, Donna; Parsons, Geoffrey; Kerr, Bredford; Hetz Flores, Claudio; Court, Felipe (Nature Publishing Group, 2016)
      Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve ...
    • Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations 
      Mollereau, B.; Rzechorzek, N. M.; Roussel, B. D.; Sedru, M.; Van den Brink, D. M.; Bailly-Maitre, Beatrice; Palladino, F.; Medinas Bilches, Danilo; Domingos, P. M.; Hunot, S.; Chandran, S.; Birman, S.; Baron, T.; Vivien, D.; Duarte, C. D.; Ryoo, H. D.; Steller, H.; Urano, F.; Chevet, E.; Kroemer, G.; Ciechanover, A.; Calabrese, E. J.; Kaufman, R. J.; Hetz Flores, Claudio (Elsevier, 2016)
      In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations ...
    • Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca(2+) Release Inducing Mitochondrial Fragmentation ... 
      Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco Friz, María Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (MARY ANN LIEBERT INC, 2011-04)
      Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
    • Autophagy meets fused in sarcoma-positive stress granules 
      Matus, Soledad; Bosco, Daryl A.; Hetz Flores, Claudio (Elsevier, 2014)
      Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures ...
    • Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore 
      Barrientos, Sebastián A.; Martínez, Nicolas W.; Yoo, Soonmoon; Jara, Juan S.; Zamorano, Sebastián; Hetz Flores, Claudio; Twiss, Jeffery L.; Alvarez, Jaime; Court, Felipe A. (SOC NEUROSCIENCE, 2011-01-19)
      Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can ...
    • Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global ... 
      Hetz Flores, Claudio; Vitte, Pierre-Alain; Bombrun, Agnes; Rostovtseva, Tatiana K.; Montessuit, Sylvie; Hiver, Agnes; Schwarz, Matthias K.; Church, Dennis J.; Korsmeyer, Stanley J.; Martinou, Jean-Claude (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005-12)
      Ischemic injuries are associated with several pathological conditions, including stroke and myocardial infarction. Several studies have indicated extensive apoptotic cell death in the infarcted area as well as in the ...
    • BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1 alpha 
      Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastián; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (CELL PRESS, 2009-03-27)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
    • Bax Inhibitor-1-mediated Ca2+leak is decreased by cytosolic acidosis 
      Kiviluoto, Santeri; Luyten, Tomas; Schneider, Lars; Lisak, Dmitrij; Rojas Rivera, Diego; Welkenhuyzen, Kirsten; Missaen, Ludwig; Smedt, Humbert De; Parys, Jan B.; Hetz Flores, Claudio; Methner, Axel; Bultynck, Geert (Elsevier, 2013)
      tBax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum(ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closelyconnected ...
    • BCL-2 family: integrating stress responses at the ER to control cell demise 
      Pihan, Philippe; Carreras Sureda, Amado; Hetz Flores, Claudio (Nature Publishing Group, 2017)
      In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of stress signals are integrated toward determining ...
    • THE BIOLOGICAL MEANING OF THE UPR 
      Hetz Flores, Claudio (Macmillan, 2013)
    • Bursting the unfolded protein response accelerates axonal regeneration 
      Oñate, Maritza; Court, Felipe A.; Hetz Flores, Claudio (Medknow Publications, 2016)
    • Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses 
      Carreras Sureda, Amado; Pihan, Philippe; Hetz Flores, Claudio (Elsevier, 2018)
      Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly regulated as it allows a favorable environment for protein folding, in addition ...
    • Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease 
      Dufey, Estefanie; Sepúlveda, Denisse; Rojas Rivera, Diego; Hetz Flores, Claudio (American Physiological Society, 2014)
      Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview. Am J Physiol Cell Physiol 307: C582–C594, 2014. First published August 20, 2014; doi:10.1152/ajpcell.00258.2014.—Increased ...
    • Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity 
      Martínez, Gabriela; Durán Aniotz, Claudia; Cabral Miranda, Felipe; Hetz Flores, Claudio (Frontiers Media, 2016)
    • Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1 
      Valdés, Pamela; Mercado, Gabriela; Vidal, René L.; Molina, Claudia; Parsons, Geoffrey; Court, Felipe A.; Martínez, Alexis; Galleguillos, Danny; Armentano, Donna; Schneider, Bernard L.; Hetz Flores, Claudio (CrossMark, 2014)
      Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although growing evidence indicates that endoplasmic reticulum (ER) stress is a hallmark ...
    • Control of systemic proteostasis by the nervous system 
      Mardones, Pablo; Martínez, Gabriela; Hetz Flores, Claudio (Elsevier, 2015)
      Maintenance of organismal homeostasis depends on the integration of intracellular and external signals, involving the ability to detect molecular perturbations. An explosion of studies in model organisms indicates ...
    • Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington’s Disease 
      Vidal Álvarez, Roberto; Caballero, B.; Couve Correa, Andrés; Hetz Flores, Claudio (Bentham Science Publishers Ltd., 2011)
      A variety of neurological diseases including Huntington’s disease (HD), Alzheimer’s disease and Parkinson’s disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing ...
    • The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology 
      Hetz Flores, Claudio; Glimcher, Laurie H. (ELSEVIER, 2008-01)
      Apoptosis is essential for maintenance of tissue homeostasis and its deregulation underlies many disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death, comprising ...