Now showing items 1-20 of 67

    • Castillo, K.; Valenzuela, V.; Oñate, M.; Hetz Flores, Claudio (Elsevier, 2017)
      The relevance of autophagy in neuronal health has been extensively reported in a plethora of conditions affecting the nervous system, such as neurodegenerative diseases, cancer, diabetes, and tissue injury, where altered ...
    • Valenzuela, V.; Collyer, E.; Armentano, D.; Parsons, G. B.; Court, F. A.; Hetz Flores, Claudio (NATURE PUBLISHING GROUP, 2012-02)
      Spinal cord injury (SCI) is a major cause of paralysis, and involves multiple cellular and tissular responses including demyelination, inflammation, cell death and axonal degeneration. Recent evidence suggests that ...
    • Oñate, Martiza; Catenaccio, Alejandra; Martínez, Gabriela; Armentano, Donna; Parsons, Geoffrey; Kerr, Bredford; Hetz Flores, Claudio; Court, Felipe (Nature Publishing Group, 2016)
      Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve ...
    • Mollereau, B.; Rzechorzek, N. M.; Roussel, B. D.; Sedru, M.; Van den Brink, D. M.; Bailly-Maitre, Beatrice; Palladino, F.; Medinas Bilches, Danilo; Domingos, P. M.; Hunot, S.; Chandran, S.; Birman, S.; Baron, T.; Vivien, D.; Duarte, C. D.; Ryoo, H. D.; Steller, H.; Urano, F.; Chevet, E.; Kroemer, G.; Ciechanover, A.; Calabrese, E. J.; Kaufman, R. J.; Hetz Flores, Claudio (Elsevier, 2016)
      In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations ...
    • Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco Friz, María Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (MARY ANN LIEBERT INC, 2011-04)
      Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
    • Matus, Soledad; Bosco, Daryl A.; Hetz Flores, Claudio (Elsevier, 2014)
      Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures ...
    • Barrientos, Sebastián A.; Martínez, Nicolas W.; Yoo, Soonmoon; Jara, Juan S.; Zamorano, Sebastián; Hetz Flores, Claudio; Twiss, Jeffery L.; Alvarez, Jaime; Court, Felipe A. (SOC NEUROSCIENCE, 2011-01-19)
      Axonal degeneration is an active process that has been associated with neurodegenerative conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory stimuli. This degenerative process can ...
    • Hetz Flores, Claudio; Vitte, Pierre-Alain; Bombrun, Agnes; Rostovtseva, Tatiana K.; Montessuit, Sylvie; Hiver, Agnes; Schwarz, Matthias K.; Church, Dennis J.; Korsmeyer, Stanley J.; Martinou, Jean-Claude (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2005-12)
      Ischemic injuries are associated with several pathological conditions, including stroke and myocardial infarction. Several studies have indicated extensive apoptotic cell death in the infarcted area as well as in the ...
    • Lisbona, Fernanda; Rojas Rivera, Diego; Thielen, Peter; Zamorano, Sebastián; Todd, Derrick; Martinon, Fabio; Glavic Maurer, Álvaro; Kress, Christina; Lin, Jonathan H.; Walter, Peter; Reed, John C.; Glimcher, Laurie H.; Hetz Flores, Claudio (CELL PRESS, 2009-03-27)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of an integrated signal transduction pathway known as the unfolded protein response (UPR). Bax inhibitor-1 (BI-1) is an evolutionarily conserved ...
    • Kiviluoto, Santeri; Luyten, Tomas; Schneider, Lars; Lisak, Dmitrij; Rojas Rivera, Diego; Welkenhuyzen, Kirsten; Missaen, Ludwig; Smedt, Humbert De; Parys, Jan B.; Hetz Flores, Claudio; Methner, Axel; Bultynck, Geert (Elsevier, 2013)
      tBax Inhibitor-1 (BI-1) is an evolutionarily conserved six-transmembrane domain endoplasmic reticulum(ER)-localized protein that protects against ER stress-induced apoptotic cell death. This function is closelyconnected ...
    • Pihan, Philippe; Carreras Sureda, Amado; Hetz Flores, Claudio (Nature Publishing Group, 2017)
      In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of stress signals are integrated toward determining ...
    • Hetz Flores, Claudio (Macmillan, 2013)
    • Oñate, Maritza; Court, Felipe A.; Hetz Flores, Claudio (Medknow Publications, 2016)
    • Carreras Sureda, Amado; Pihan, Philippe; Hetz Flores, Claudio (Elsevier, 2018)
      Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly regulated as it allows a favorable environment for protein folding, in addition ...
    • Dufey, Estefanie; Sepúlveda, Denisse; Rojas Rivera, Diego; Hetz Flores, Claudio (American Physiological Society, 2014)
      Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview. Am J Physiol Cell Physiol 307: C582–C594, 2014. First published August 20, 2014; doi:10.1152/ajpcell.00258.2014.—Increased ...
    • Martínez, Gabriela; Durán Aniotz, Claudia; Cabral Miranda, Felipe; Hetz Flores, Claudio (Frontiers Media, 2016)
    • Valdés, Pamela; Mercado, Gabriela; Vidal, René L.; Molina, Claudia; Parsons, Geoffrey; Court, Felipe A.; Martínez, Alexis; Galleguillos, Danny; Armentano, Donna; Schneider, Bernard L.; Hetz Flores, Claudio (CrossMark, 2014)
      Parkinson disease (PD) is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta (SNpc). Although growing evidence indicates that endoplasmic reticulum (ER) stress is a hallmark ...
    • Mardones, Pablo; Martínez, Gabriela; Hetz Flores, Claudio (Elsevier, 2015)
      Maintenance of organismal homeostasis depends on the integration of intracellular and external signals, involving the ability to detect molecular perturbations. An explosion of studies in model organisms indicates ...
    • Vidal Álvarez, Roberto; Caballero, B.; Couve Correa, Andrés; Hetz Flores, Claudio (Bentham Science Publishers Ltd., 2011)
      A variety of neurological diseases including Huntington’s disease (HD), Alzheimer’s disease and Parkinson’s disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing ...
    • Hetz Flores, Claudio; Glimcher, Laurie H. (ELSEVIER, 2008-01)
      Apoptosis is essential for maintenance of tissue homeostasis and its deregulation underlies many disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death, comprising ...