Browsing by Author "XX609648"
Now showing items 21-40 of 63
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Ramírez, Marcos; Gallardo, Andrés; Vidal, Aarón; Cornejo, Sebastián; Ramírez, Darío; Medinas Bilches, Danilo; Bustamante Fontecilla, Gonzalo; Pasquali, Renzo; Hetz Flores, Claudio (Soc Médica Santiago, 2016)Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man ...
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Hetz Flores, Claudio; Mollereau, Bertrand (Macmillan, 2014)Abstract | The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well characterized in non-neuronal cells, ...
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Mercado Guerra, María Gabriela; Hetz Flores, Claudio (Oxford University Press, 2017-06)
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Gerakis, Yannis; Hetz Flores, Claudio (Wiley, 2018)Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid- peptides or phosphorylated tau proteins. Accumulating ...
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Chevet, Eric; Hetz Flores, Claudio; Samali, Afshin (Amer Assoc Cancer Research, 2015)Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is observed in many human diseases, including cancers. Cellular adaptation to ER stress is mediated by the unfolded protein response ...
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Torres, Mauricio; Matamala, José Manuel; Durán Aniotz, Claudia; Cornejo, Víctor Hugo; Foley, Andrew; Hetz Flores, Claudio (Elsevier, 2015)Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are ...
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Mercado, Gabriela; Valdés, Pamela; Hetz Flores, Claudio (Elsevier, 2013-03)Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
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Sepúlveda, Martín; Rozas, Pablo; Hetz Flores, Claudio; Medinas Bilches, Danilo (TAYLOR & FRANCIS, 2016)Disturbance of endoplasmic reticulum (ER) proteostasis is observed in Prion-related disorders (PrDs). The protein disulfide isomerase ERp57 is a stress-responsive ER chaperone up-regulated in the brain of Creutzfeldt-Jakob ...
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Bargsted, Leslie; Hetz Flores, Claudio; Matus, Soledad (MEDKNOW PUBLICATIONS & MEDIA, 2016)
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Matus, Soledad; López, Estefanía; Valenzuela, Vicente; Nassif, Melissa; Hetz Flores, Claudio (PUBLIC LIBRARY SCIENCE, 2013-07-18)Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation ...
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Castillo, Valentina; Oñate, Maritza G.; Woehlbier, Ute; Rozas, Pablo; Andreu, Catherine; Medinas Bilches, Danilo; Valdés, Pamela; Osorio, Fabiola; Mercado, Gabriela; Vidal, René L.; Kerr, Bredford; Court, Felipe A.; Hetz Flores, Claudio (Public Library Science, 2015)ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common ...
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Castillo, Valentina; Mercado, Gabriela; Hetz Flores, Claudio (Medknow Publications & Media Pvt Ltd, 2015)
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Durán Aniotz, Claudia; Hetz Flores, Claudio (2016)Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate that enhancing glucose uptake in neurons ...
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Klionsky, Daniel J.; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Glavic Maurer, Álvaro; Corbalán, Ramón; Matus, Soledad; Segura Aguilar, Juan; Hetz Flores, Claudio (Taylor & Francis inc., 2016)
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González Quiroz, Matias; Urra, Hery; Limia, Celia María; Hetz Flores, Claudio (Elsevier, 2018-06)Cancer cells are exposed to adverse conditions within the tumor microenvironment that challenge cells to adapt and survive. Several of these homeostatic perturbations insults alter the normal function of the endoplasmic ...
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González Pérez, Paloma; Woehlbier, Ute; Chian, Ru-Ju; Sapp, Peter; Rouleau, Guy A.; Leblond, Claire S.; Daoud, Hussein; Dion, Patrick A.; Landers, John E.; Hetz Flores, Claudio; Brown, Robert H. (Elsevier, 2015)Disruption of endoplasmic reticulum (ER) proteostasis is a salient feature of amyotrophic lateral sclerosis (ALS). Upregulation of ER foldases of the protein disulfide isomerase (PDI) family has been reported in ALS mouse ...
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Rodríguez, Diego A.; Rojas Rivera, Diego; Hetz Flores, Claudio (Elsevier, 2011-04)The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium homeostasis. autophagy, ER morphogenesis and protein folding. Diverse ...
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Durán Aniotz, Claudia; Cornejo, Victor Hugo; Espinoza, Sandra; Ardiles, Alvaro O.; Medinas Bilches, Danilo; Salazar, Claudia; Foley, Andrew; Gajardo, Ivana; Thielen, Peter; Iwawaki, Takao; Scheper, Wiep; Soto, Claudio; Palacios, Adrian G.; Hoozemans, Jeroen J. M.; Hetz Flores, Claudio (Springer, 2017)Altered proteostasis is a salient feature of Alzheimer's disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded ...
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Durán Aniotz, Claudia Andrea; Martínez, Gabriela; Hetz Flores, Claudio (2014)
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Mardones, Pablo; Rubinsztein, David; Hetz Flores, Claudio (AAAS, 2016)Although vertebrates cannot synthesize the natural disaccharide trehalose, exogenous administration of trehalose to mammalian cells may be beneficial for protein misfolding disorders. In this issue, DeBosch et al. show ...