Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob. Caso clínico
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Ramírez, Marcos
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Desafíos en el diagnóstico de enfermedad de Creutzfeldt-Jakob. Caso clínico
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Abstract
Creutzfeldt-Jakob disease has a higher incidence in Chile than in other
countries. The post mortem pathological characterization of brain tissue is
necessary to reach a definitive diagnosis. We report a 73 years old man with
a history compatible with of a rapidly progressive dementia, in which the first
electroencephalographic study showed a pattern consistent with non-convulsive
status epilepticus. Besides discarding this diagnosis, it was necessary to rule out
other causes of rapidly progressive dementia such as Hashimoto encephalopathy.
Finally, the sustained clinical deterioration with no response to anticonvulsants
and corticosteroids, the imaging studies, a serial electroencephalographic
monitoring study and the detection of 14-3-3 protein in cerebrospinal fluid
were the keys to achieve the diagnosis of the disease.
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Rev Med Chile 2016; 144: 806-811
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