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The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology

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2008-01
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Hetz Flores, Claudio
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The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology
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  • Hetz Flores, Claudio;
  • Glimcher, Laurie H.;
Abstract
Apoptosis is essential for maintenance of tissue homeostasis and its deregulation underlies many disease conditions. The BCL-2 family of proteins is a group of evolutionarily conserved regulators of cell death, comprising both anti- and pro-apoptotic members, which operate at the mitochondrial membrane to control caspase activation. Different BCL-2-related proteins are also located in multiprotein complexes at the endoplasmic reticulum (ER), which are involved in the control of diverse cellular processes, including calcium homeostasis, autophagy, the unfolded protein response and ER morphogenesis. Here, we describe the emerging concept that BCL-2-related proteins have alternative functions beyond apoptosis to control the essential functions of the cell.
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URI: https://repositorio.uchile.cl/handle/2250/128405
DOI: 10.1016/j.tcb.2007.10.003
ISSN: 0962-8924
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TRENDS IN CELL BIOLOGY Volume: 18 Issue: 1 Pages: 38-44 Published: JAN 2008
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