Now showing items 1-20 of 22

    • Budini, Mauricio; Buratti, Emanuele; Morselli, Eugenia; Criollo Céspedes, Alfredo (Frontiers, 2017-05-30)
      Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures called autophagolysosomes. Autophagy is necessary to maintain the normal function of the central nervous system (CNS), ...
    • Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; García Nannig, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Ormeño, Fernando; Hormazábal, Juan; Moreno, José; Riquelme, Felipe; Ríos, Javiera; Criollo Céspedes, Alfredo; Albornoz, Amelina; Alfaro, Iván E.; Budini, Mauricio (Frontiers Media, 2020)
      TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) are fatal neurodegenerative ...
    • Criollo Céspedes, Alfredo; Galluzzi, Lorenzo; Chiara Maiuri, M.; Tasdemir, Ezgi; Lavandero González, Sergio; Kroemer, Guido (Springer Science+Business, 2013)
      Errors were inadvertently included in Fig. 6b of the article mentioned above. In particular, the immunoblots depicting the levels of Bcl-XL and Mcl-1, which were originally intended to constitute loading controls for ...
    • Villalobos, Elisa; Criollo Céspedes, Alfredo; Schiattarella, Gabriele G.; Altamirano, Francisco; French, Kristin M.; May, Herman I.; Jiang, Nan; Nguyen, Ngoc Uyen Nhi; Romero, Diego; Roa, Juan Carlos; García Nannig, Lorena; Díaz Araya, Guillermo; Morselli, Eugenia; Ferdous, Anwarul (NLM (Medline), 2019)
      BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have ...
    • Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (2006)
      NFκB is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NFκB pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase and cell ...
    • Peña Oyarzún, Daniel; Troncoso Cotal, Rodrigo; Kretschmar, Catalina; Hernando, Cecilia; Budini, Mauricio; Morselli, Eugenia; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Impact Journals, 2017)
      Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
    • Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibañez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (2006)
      We have recently shown that hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFκB is regulated in cultured rat ...
    • Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Hélène; Maiuri, Maria Chiara; Morselli, Eugenia; Vitale, Ilio; Kepp, Oliver; Tasdemir, Ezgi; Galluzzi, Lorenzo; Shen, Si; Tailler, Maximilien; Delahaye, Nicolas; Tesniere, Antoine; De Stefano, Daniela; Younes, Aména Ben; Harp (Taylor and Francis Inc., 2010)
      Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both ...
    • Morselli, Eugenia; Santos, Roberta de Souza; Gao, Su; Avalos, Yenniffer; Criollo Céspedes, Alfredo; Palmer, Biff F.; Clegg, Deborah J. (American Physiological Society, 2018-07)
      Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose ...
    • Morselli, Eugenia; de Souza Santos, Roberta; Gao, Su; Ávalos, Yenniffer; Criollo Céspedes, Alfredo; Palmer, Biff F.; Clegg, Deborah J. (American Physiological Society, 2018)
      © 2018 American Physiological Society. All rights reserved. Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes ...
    • Criollo Céspedes, Alfredo; Niso-Santano, Mireia; Malik, Shoaib Ahmad; Michaud, Mickael; Morselli, Eugenia; Mariño, Guillermo; Lachkar, Sylvie; Arkhipenko, Alexander V.; Harper, Francis; Pierron, Gérard; Rain, Jean Christophe; Ninomiya-Tsuji, Jun; Fuentes, José M.; Lavandero González, Sergio (2011)
      Autophagic responses are coupled to the activation of the inhibitor of NF-κB kinase (IKK). Here, we report that the essential autophagy mediator Beclin 1 and TGFβ-activated kinase 1 (TAK1)-binding proteins 2 and 3 (TAB2 ...
    • Peña Oyarzún, Daniel; Batista González, Ana; Kretschmar, Catalina; Burgos, Paulina; Lavandero González, Sergio; Morselli, Eugenia; Criollo Céspedes, Alfredo (Elsevier, 2020)
      Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic membrane, and the primary cilium. The structure of PC2 is characterized by a highly ordered C-terminal tail with an ...
    • Batista González, Ana; Vidal Álvarez, Roberto; Criollo Céspedes, Alfredo; Carreño Márquez, Leandro (Frontiers Media, 2020)
      Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1) macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by relying on aerobic glycolysis and fatty acid ...
    • Reyes Rojas, Montserrat; Peña Oyarzún, Daniel; Silva, Patricio; Venegas, Sebastián; Criollo Céspedes, Alfredo; Torres Gómez, Vicente (Wiley, 2020)
      Potentially malignant lesions, commonly referred to as dysplasia, are associated with malignant transformation by mechanisms that remain unclear. We recently reported that increased Wnt secretion promotes the nuclear ...
    • Hernández Cáceres, María Paz; Cereceda, Karina; Hernández, Sergio; Li, Ying; Narro, Carla; Rivera, Patricia; Silva, Patricio; Ávalos, Yenniffer; Jara, Claudia; Burgos, Paulina; Toledo Valenzuela, Lilian; Lagos, Pablo; Cifuentes Araneda, Flavia; Pérez Leighton, Claudio; Bertocchi, Cristina; Clegg, Deborah J.; Criollo Céspedes, Alfredo; Tapia Rojas, Cheril; Burgos, Patricia V.; Morselli, Eugenia (Taylor & Francis, 2020)
      High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed ...
    • Peña Oyarzún, Daniel; Rodríguez Peña, Marcelo; Burgos Bravo, Francesca; Vergara, Ángelo; Kretschmar Montecinos, Catalina; Sotomayor Flores, Cristián; Ramírez Sarmiento, César A.; De Smedt, Humbert; Reyes Rojas, Montserrat; Pérez, William; Torres Gómez, Vicente; Morselli, Eugenia; Altamirano, Francisco; Wilson, Christian; Hill, Joseph A.; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Taylor & Francis, 2020)
      Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a ...
    • Budini, Mauricio; Criollo Céspedes, Alfredo (AME Publishing Company, 2017)
    • Kretschmar, Catalina; Peña Oyarzún, Daniel; Hernando, Cecilia; Hernández Moya, Nadia; Molina Berríos, Alfredo Enrique; Hernández-Cáceres, María Paz; Lavandero González, Sergio; Budini, Mauricio; Morselli, Eugenia; Parra, Valentina; Troncoso, Rodrigo; Criollo Céspedes, Alfredo (Frontiers Media S.A., 2019)
      Copyright © 2019 Kretschmar, Peña-Oyarzun, Hernando, Hernández-Moya, Molina-Berríos, Hernández-Cáceres, Lavandero, Budini, Morselli, Parra, Troncoso and Criollo.Muscle atrophy involves a massive catabolism of intracellular ...
    • Criollo Céspedes, Alfredo; Altamirano, Francisco; Pedrozo Cibils, Zully; Schiattarella, Gabriele G.; Li, Dan L.; Rivera‐Mejias, Pablo; Sotomayor Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K.; Jiang, Nan; May, Herman I.; Morselli, Eugenia; Somlo, Stefan; Smedt, Humbert de; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Elsevier, 2018-05)
      Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...