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Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism

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2018-07
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Morselli, Eugenia
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Impact of estrogens and estrogen receptor-alpha in brain lipid metabolism
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Author
  • Morselli, Eugenia;
  • Santos, Roberta de Souza;
  • Gao, Su;
  • Avalos, Yenniffer;
  • Criollo Céspedes, Alfredo;
  • Palmer, Biff F.;
  • Clegg, Deborah J.;
Abstract
Estrogens and their receptors play key roles in regulating body weight, energy expenditure, and metabolic homeostasis. It is known that lack of estrogens promotes increased food intake and induces the expansion of adipose tissues, for which much is known. An area of estrogenic research that has received less attention is the role of estrogens and their receptors in influencing intermediary lipid metabolism in organs such as the brain. In this review, we highlight the actions of estrogens and their receptors in regulating their impact on modulating fatty acid content, utilization, and oxidation through their direct impact on intracellular signaling cascades within the central nervous system.
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Fondo Nacional de Desarrollo Cientifico y Tecnologico 1160820 1171075 FONDAP-ACCD 15130011 CONICYT PCI 170147 International Centre for Genetic Engineering and Biotechnology Grant CRP/CHL16-06
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Artículo de publicación ISI
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URI: https://repositorio.uchile.cl/handle/2250/159219
DOI: 10.1152/ajpendo.00473.2017
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American Journal of Physiology-Endocrinology and Metabolism Volumen: 315 Número: 1 Páginas: E7-E14
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