Browsing by Author "dfb12160-0add-4d60-bc6d-8a52c6c79f26"

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    • T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation 
      Acuña Castillo, Claudio; Aravena, Mauricio; Leiva Salcedo, Elías; Pérez, Viviana; Gómez, Christian; Sabaj Diez, Valeria; Nishimura, Sumiyo; Pérez Núñez, Claudio; Colombo, Alicia; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2005-12)
      Plasma levels of kininogens increase with age in both rats and humans. Kininogens are inhibitors of cysteine proteinases, and filarial cysteine proteinase inhibitors (cystatins) reduce the proliferation of T cells. We ...
    • T-kininogen: A biomarker of aging in fisher 344 rats with possible implications for the immune response 
      Acuña Castillo, Claudio; Leiva-Salcedo, Elias; Gómez, Christian R.; Pérez, Viviana; Li, Min; Torres, Claudio; Walter, Robin Ann; Murasko, Donna M.; Sierra, Felipe (Gerontological Society of America, 2006)
      T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG ...