Now showing items 1-20 of 34

    • Wilson, Carlos; Muñoz Palma, Ernesto; Henríquez, Daniel R.; Palmisano, Ilaria; Núñez González, Marco; Di Giovanni, Simone; González Billault, Christian (Soc Neuroscience, 2016-10-26)
      Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2+, a broad intracellular second messenger, promotes both Rac1 ...
    • Thumala Dockendorff, Daniela Cecilia; Kennedy, Brian K.; Calvo, Esteban; González Billault, Christian; Zitko, Pedro; Lillo Zurita, Patricia; Villagra Castro, Roque; Ibáñez, Agustín; Assar, Rodrigo; Andrade, Maricarmen; Slachevsky Chonchol, Andrea (Routledge, 2017)
      Population aging is among the most important global transformations. Compared to European and North American countries, Chile is among the countries with the fastest growth of life expectancy at birth during recent decades. ...
    • Musa Salech, Gada; Slachevsky Chonchol, Andrea; Muñoz Neira, Carlos; Méndez, Carolina; Villagra Castro, Roque; González Billault, Christian; Ibáñez, Agustín; Hornberger, Michael; Lillo, Patricia (IOS Press, 2020)
      Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common neurodegenerative early-onset dementias. Despite the fact that both conditions have a very distinctive clinical pattern, they present with an ...
    • Alvarez Armijo, Sergio; Bodaleo, F.; Fukuda, M.; González Billault, Christian (American Society Cell Biology, 2017)
    • Mendoza Naranjo, Ariadna; González Billault, Christian; Maccioni Baraona, Ricardo (2007)
      A number of psychiatric and neurodegenerative disorders, such as Alzheimer's disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced by ...
    • Rodriguez, Diego A.; Zamorano, Sebastian; Lisbona, Fernanda; Rojas Rivera, Diego; Urra, Hery; Cubillos-Ruiz, Juan R.; Armisen Yáñez, Ricardo; Henriquez, Daniel R.; Cheng, Emily; Letek, Michal; Vaisar, Tomas; Irrazabal, Thergiory; González Billault, Christian; Letai, Antho (2012)
      Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the unfolded protein response (UPR) stress sensor inositol-requiring enzyme 1α(IRE1α), which functions as an endoribonuclease that splices the ...
    • Furusawa, Kotaro; Asada, Akiko; Urrutia, Pamela; González Billault, Christian; Fukuda, Mitsunori; Hisanaga, Shin-ichi (Society for Neuroscience, 2017)
      Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
    • González, Andrés; Moya Alvarado, Guillermo; González Billault, Christian; Bronfman, Francisca (Wiley, 2016)
      Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms ...
    • Cabeza, Carolina; Figueroa, Alicia; Lazo, Oscar M.; Galleguillos, Carolina; Pissani, Claudia; Klein, Andrés; González Billault, Christian; Inestrosa, Nibaldo C.; Alvarez, Alejandra R.; Zanlungo, Silvana; Bronfman, Francisca (2012)
      Background: Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. Neurotrophin receptors are active in signaling endosomes, which ...
    • Acevedo, Alejandro; González Billault, Christian (Elsevier, 2018)
      The small RhoGTPase Rac1 is implicated in a variety of events related to actin cytoskeleton rearrangement. Remarkably, another event that is completely different from those related to actin regulation has the same relevance; ...
    • Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; González Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras Puratich, Elías (Lippincott Williams & Wilkins, 2017)
      The purinergic P2X2 receptor (P2X2R) is an adenosine triphosphate-gated ion channel widely expressed in the nervous system. Here, we identified a putative cyclin-dependent kinase 5 (Cdk5) phosphorylation site in the full-size ...
    • Bórquez Muñoz, Daniel; Urrutia, Pamela J.; Wilson, Carlos; Van Zundert, Brigitte; Núñez González, Marco; González Billault, Christian (Wiley-Blackwell, 2016)
      The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physiological ROS production modulates redox-sensitive ...
    • Aboitiz, Francisco; Concha, Miguel L.; González Billault, Christian; Mpodozis Marín, Jorge (Frontiers Media SA., 2018-06-29)
    • Slater, Paula G.; Ramírez, Valerie T.; González Billault, Christian; Varela Nallar, Lorena; Inestrosa, Nibaldo C. (2013)
      The Wnt signaling pathway plays important roles during different stages of neuronal development, including neuronal polarization and dendritic and axonal outgrowth. However, little is known about the identity of the ...
    • Wilson, Carlos; Muñoz Palma, Ernesto; González Billault, Christian (Elsevier, 2018-08)
      Historically, ROS have been considered toxic molecules, especially when their intracellular concentration reaches high values. However, physiological levels of ROS support crucial cellular processes, acting as second ...
    • Slachevsky Chonchol, Andrea; Zitko, Pedro; Martínez Pernía, David; Forno, Gonzalo; Court, Felipe A.; Lillo, Patricia; Villagra Castro, Roque; Durán Aniotz, Claudia Andrea; Parrao, Teresa; Assar, Rodrigo; Orellana, Paulina; Toledo, Carolina; Rivera, Rodrigo; Ibáñez, Agustín; Parra, Mario A.; González Billault, Christian; Amieva, Helena; Thumala, Daniela (BMC, 2020)
      Background: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly ...
    • Contreras Vallejos, Erick; Utreras Puratich, Elías; González Billault, Christian (Elsevier, 2012)
      Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal ...
    • Urrutia, Pamela J.; Hirsch, Etienne C.; González Billault, Christian; Núñez González, Marco (Wiley, 2017)
      Alzheimer's disease (AD) is characterized by extracellular senile plaques, intracellular neurofibrillary tangles, and neuronal death. Aggregated amyloid-beta (A beta) induces inflammation and oxidative stress, which have ...
    • Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Gómez, Francisco J.; Aguirre, Pabla; González Billault, Christian; Núñez González, Marco (2011)
      Studies in post-mortem tissues of patients with Parkinson's disease (PD) and in mice treated with 6-hydroxydopamine have shown a decrease in the length of axon and dendrites of striatal neurons. However, the etiology of ...