Cellular and molecular mechanisms regulating neuronal growth by brain-derived neurotrophic factor
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Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth.
FB was supported by Fondecyt (Grant 1120146), Basal center of excellence in science and technology (PFB-12/2007) and Millenium Nucleus of Regenerative Biology, MINREB, (P07/011-F). CGB was supported by Fondecyt (Grant 1140325) and FONDAP Program (Grant 15150012). AG and GMA are or were supported by PhD doctoral fellowships from Fondecyt.
Artículo de publicación ISI
Quote ItemCytoskeleton, October 2016 73:612–628
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