Browsing by Author "Hill, Joseph A."

Now showing items 21-25 of 25

    • Regulation of cardiomyocyte autophagy by calcium 
      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway 
      Wang, Zhao V.; Deng, Yingfeng; Gao, Ningguo; Pedrozo Cibils, Zully; Li, Dan L.; Morales, Cyndi R.; Criollo Céspedes, Alfredo; Luo, Xiang; Tan, Wei; Jiang, Nan; Lehrman, Mark A.; Rothermel, Beverly A.; Lee, Ann Hwee; Lavandero González, Sergio; Mammen, Pradeep P .A.; Ferdous, Anwarul; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A. (Elsevier, 2014-03-13)
      The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the ...
    • The complex interplay between mitochondrial dynamics and cardiac metabolism 
      Parra Ortíz, María Valentina; Verdejo, Hugo; Campo Sfeir, Andrea Estefanía del; Pennanen Saavedra, Christian; Kuzmicic, Jovan; Iglewski, Myriam; Hill, Joseph A.; Rothermel, B. A.; Lavandero González, Sergio (SPRINGER/PLENUM PUBLISHERS, 2011-02)
      Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of ...
    • Tuning flux: autophagy as a target of heart disease therapy 
      Xie, Min; Morales, Cindy R.; Lavandero González, Sergio; Hill, Joseph A. (LIPPINCOTT WILLIAMS & WILKINS, 2011-05)
      Whereas we have known for some years of the participation of lysosomal mechanisms in heart disease, it is only recently that upstream mechanisms (autophagy) are being explored. The challenge for the future is to dissect ...
    • Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ... 
      Schiattarella, Gabriele G.; Altamirano, Francisco; Young Kim, Soo; Tong, Dan; Ferdous, Anwarul; Piristine, Hande; Dasgupta, Subhajit; Wang, Xuliang; French, Kristin M.; Villalobos, Elisa; Spurgin, Stephen B.; Waldman, Maayan; Jiang, Nan; May, Herman I.; Hill, Theodore M.; Luo, Yuxuan; Yoo, Heesoo; Zaha, Vlad G.; Lavandero González, Sergio Alejandro; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2021)
      Heart failure with preserved ejection fraction (HFpEF) is now the dominant form of heart failure and one for which no efficacious therapies exist. Obesity and lipid mishandling greatly contribute to HFpEF. However, molecular ...