Browsing by Author "Iturriaga-Vásquez, Patricio"

Now showing items 21-27 of 27

    • Neonicotinic analogues: Selective antagonists for α4β2 nicotinic acetylcholine receptors 
      Faundez Parraguez, Manuel; Farías Rabelo, Nicolás; González Gutiérrez, Juan Pablo; Etcheverry Berríos, Alvaro; Alzate-Morales, Jans; Adasme-Carreño, Francisco; Varas, Rodrigo; Bermudez, Isabel; Iturriaga-Vásquez, Patricio (2013)
      Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to ...
    • Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine ... 
      Alcaino, Constanza; Musgaard, Maria; Minguez, Teresa; Mazzaferro, Simone; Faundez, Manuel; Iturriaga-Vásquez, Patricio; Biggin, Philip C.; Bermudez, Isabel (American Society for Biochemistry and Molecular Biology Inc., 2017)
      © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...
    • Simplified Tetrandrine Congeners as Possible Antihypertensive Agents with a Dual Mechanism of Action 
      Iturriaga-Vásquez, Patricio; Miquel, Raquel; Ivorra, M. Dolores; D’Ocon, M. Pilar; Cassels Niven, Bruce (American Chemical Society and American Society of Pharmacognosy, 2003-02-07)
      A series of O- and/or N-substituted derivatives of (()-coclaurine (1a) were synthesized as simplified structural mimics of the antihypertensive alkaloid tetrandrine (2) and assayed for binding to brain cortical sites ...
    • Síntesis y evaluación farmacológica de posibles inhibidores de monoamino oxidasa 
      Vilches herrera, Luis Marcelo (Universidad de Chile, 2008)
      Este trabajo de tesis consiste en la síntesis de dos series de compuestos: 6-alcoxi-2-naftilisopropilaminas y 4-alquiltiofenilisopropilaminas. También incluyen su evolución bioquímica preliminar como inhibidores de la ...
    • Synthesis of 2-aryl-1,3-propanediamines using a one-pot Knoevenagel-Michael sequence 
      Iturriaga-Vásquez, Patricio; Lühr Sierra, Susan; Caroli Rezende, Marcos; Cassels Niven, Bruce (SOCIEDAD CHILENA DE QUIMICA, 2006-03)
      A simple synthetic route for the preparation of 2-phenyl-1,3-propanediamines, based on a Knoevenagel-Michael double condensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium ...
    • SYNTHESIS OF 2-ARYL-l,3-PROPANEDIAMlNES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE 
      Iturriaga-Vásquez, Patricio; Lühr-Sierra, Susan; Caroli Rezende, Marcos; Cassels Niven, Bruce (Sociedad Química de Chile, 2006)
      A simple synthetic route for the preparation of 2-phenyl-I,3-propanediamines, based on a Knoevenagel-Michael double .:ondensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium ...
    • Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole ... 
      Pessoa Mahana, Hernán; González Lira, Christian; Fierro, Angélica; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Ortiz Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes Parada, Miguel; Silva Matus, Paul; Saitz Barría, Claudio; Araya Maturana, Ramiro (Elsevier, 2013)
      A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter ...