SYNTHESIS OF 2-ARYL-l,3-PROPANEDIAMlNES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE
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Iturriaga-Vásquez, Patricio
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SYNTHESIS OF 2-ARYL-l,3-PROPANEDIAMlNES USING A ONE-POT KNOEVENAGEL-MICHAEL SEQUENCE
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Abstract
A simple synthetic route for the preparation of 2-phenyl-I,3-propanediamines, based on a Knoevenagel-Michael double
.:ondensation followed by reduction, was developed using nitromethane as reagent and solvent, and sodium bicarbonate as base in
¡he first step, followed by catalytic hydrogenation over Adams catalyst.
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This work was supported by ICM grant W P99-03I-F and
FONDECYT grant N° 1040776.
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J. Chil. Chem. Soc ., Vol. 51, Nº 1, 2006.
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