Browsing by Author "Jaimovich Pérez, Enrique"
Now showing items 21-40 of 45
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Jaimovich Pérez, Enrique; Casas, M. (Blackwell Publishing Ltd, 2018)
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Fernández Verdejo, Rodrigo; Casas, M.; Galgani Fuentes, José; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (Georg Thieme Verlag, 2014)Active skeletal muscle synthesizes and releases interleukin-6 (IL-6), which plays important roles in the organism's adaptation to exercise. Autocrine/paracrine ATP signaling has been shown to modulate IL-6 expression. The ...
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Reyes, Roberto; Jaimovich Pérez, Enrique (Academic Press Inc., 1996)We studied the influence of muscarinic and nicotinic stimulation on both phosphoinositide metabolism and intracellular calcium levels in rat skeletal muscle primary cultures. Both nicotine and muscarine induced an increase ...
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Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
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Altamirano, Francisco; López, Jose R.; Henríquez, Carlos; Molinski, Tadeusz; Allen, Paul D.; Jaimovich Pérez, Enrique (2012)Duchenne muscular dystrophy (DMD) is a genetic disorder caused by dystrophin mutations, characterized by chronic inflammation and severe muscle wasting. Dystrophic muscles exhibit activated immune cell infiltrates, ...
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Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (Kluwer Academic Publishers-Plenum Publishers, 1989)The role of inositol trisphosphate as a chemical messenger in excitation-contraction coupling is discussed, both in terms of positive and negative results. The evidence presented includes experiments on the effect of ...
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Espinosa, Alejandra; Campos, Cristian; Díaz Vegas, Alexis; Galgani Fuentes, José; Juretic Díaz, Nevenka Militza; Osorio Fuentealba, César; Bucarey, José L.; Tapia, Gladys; Valenzuela, Rodrigo; Contreras Ferrat, Ariel Eduardo; Llanos Vidal, Paola; Jaimovich Pérez, Enrique (2013)Insulin resistance is defined as a reduced ability of insulin to stimulate glucose utilization. C57BL/6 mice fed with a high-fat diet (HFD) are a model of insulin resistance. In skeletal muscle, hydrogen peroxide (H2O2) ...
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Jaimovich Pérez, Enrique; Carrasco, María Angélica (Society of Biology of Chile, 2002)Potassium depolarization of cultured muscle cells was employed to study cellular responses linked to calcium signaling. Events occurring after depolarization include i) A transient increase of the IP3 mass (2-10s); ii) A ...
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Valladares, Denisse; Utreras Mendoza, Yildy; Campos, Cristian; Morales, Camilo; Díaz Vegas, Alexis; Contreras Ferrat, Ariel Eduardo; Westermeier, Francisco; Jaimovich Pérez, Enrique; Marchi, Saverio; Pinton, Paolo; Lavandero González, Sergio (Elsevier B.V., 2018)© 2018 Duchenne muscular dystrophy (DMD) is characterized by a severe and progressive destruction of muscle fibers associated with altered Ca2+ homeostasis. We have previously shown that the IP3 receptor (IP3R) plays a ...
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Casas, Mariana; Figueroa, Reinaldo; Jorquera, Gonzalo; Escobar, Matías; Molgó, Jordi; Jaimovich Pérez, Enrique (2010)Tetanic electrical stimulation induces two separate calcium signals in rat skeletal myotubes, a fast one, dependent on Cav 1.1 or dihydropyridine receptors (DHPRs) and ryanodine receptors and related to contraction, and a ...
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Riquelme, Gloria; Jaimovich Pérez, Enrique; Lingsch, Carlota; Behn Thiele, Claus (1982)Chemically induced shape changes of the human erythrocyte may result from cell membrane bending by surface tension changes at the lipid bilayer (Evans, E.A. (1947) Biophys. J. 14, 923-931) implicating differential expansion ...
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Jorquera, Gonzalo; Juretic Díaz, Nevenka Militza; Jaimovich Pérez, Enrique; Riveros, Nora (2009)Heat shock proteins (HSPs) are a conserved family of cytoprotective polypeptides, synthesized by cells in response to stress. Hsp70 and heme oxygenase 1 (Hmox-1) are induced by a variety of cellular stressors in skeletal ...
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Eltit Ortega, José Miguel; García, Alejandra; Hidalgo, Jorge; Liberona, José L.; Chiong Lay, Mario; Lavandero González, Sergio; Maldonado, Edio; Jaimovich Pérez, Enrique (American Society for Biochemistry and Molecular Biology Inc., 2006)Tetanic electrical stimulation of myotubes evokes a ryanodine receptor-related fast calcium signal, during the stimulation, followed by a phospholipase C/inositol 1,4,5-trisphosphate-dependent slow calcium signal few seconds ...
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Eisner, Verónica; Parra, Valentina; Lavandero González, Sergio; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (Elsevier Ltd, 2010)Mitochondria sense cytoplasmic Ca2+ signals in many cell types. In mammalian skeletal myotubes, depolarizing stimuli induce two independent cytoplasmic Ca2+ signals: a fast signal associated with contraction and a slow ...
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Rosemblatt Silber, Mario César; Pérez, Gonzalo; Jaimovich Pérez, Enrique (Kluwer Academic Publishers, 1991)We have established several hybridoma lines that produce monoclonal antibodies against transverse tubule (t-tubule) proteins from frog skeletal muscle. The specificity of these antibodies was characterized by ELISA and ...
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Henríquez Olguín, Carlos (Universidad de Chile, 2018-07)Physical activity plays a protective role in the development of chronic non-communicable diseases. Molecular adaptations explain the beneficial effects of exercise in diverse tissues such as skeletal muscle, adipose ...
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Espinosa, Alejandra; García, Alejandra; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (2009)Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and that enhances the production of reactive oxygen species (ROS) in different cell types. ROS, ...
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Valdés, Juan Antonio; Segura Hidalgo, Jorge Antonio; Galaz, José Luis; Puentes, Natalia; Silva, Mónica; Jaimovich Pérez, Enrique; Carrasco, M. Angélica (2007)Depolarization of skeletal muscle cells by either high external K + or repetitive extracellular field potential pulses induces calcium release from internal stores. The two components of this release are mediated by either ...
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Valdés, Juan Antonio; Gaggero, Eduardo; Hidalgo Tapia, Jorge; Leal, Nancy; Jaimovich Pérez, Enrique; Carrasco Friz, María Angélica (AMER PHYSIOLOGICAL SOC, 2008-03)Depolarization of skeletal muscle cells triggers intracellular calcium signals mediated by ryanodine and IP3 receptors. We have reported that K+-induced depolarization activates the transcriptional regulators ERKs, CREB, ...
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Altamirano, Francisco; Valladares, Denisse; Henríquez Olguín, Carlos; Casas, Mariana; López, Jose R.; Allen, Paul D.; Jaimovich Pérez, Enrique (2013)Duchenne Muscular Dystrophy (DMD) is a recessive X-linked genetic disease, caused by mutations in the gene encoding dystrophin. DMD is characterized in humans and in mdx mice by a severe and progressive destruction of ...