Browsing by Title
Now showing items 27850-27869 of 92550
-
Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein (Impact Journals LLC, 2020)Alzheimer’s disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. ...
-
(Lippincott Williams & Wilkins, 2018)Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
-
(Blackwell Publishing Ltd, 2016)©2016 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd Aim: Previous studies have suggested that Down's syndrome is an independent risk factor for severe respiratory infection due to respiratory syncytial ...
-
(2009)The inhibitory effect of a specific small EGR-1 interfering RNA (siRNA) on cell proliferation and the expression of EGR-1 in human prostate carcinoma cell lines PC-3 and LNCaP was investigated. To knockdown Egr-1 expression, ...
-
Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation (Elsevier, 2015)The early endosomal protein Rab5 is highly expressed in tumor samples, although a causal relationship between Rab5 expression and cell transformation has not been established. Here, we report the functional effects of ...
-
(MDPI AG, 2019)Gestational diabetes mellitus (GDM) is a common metabolic disorder, defined by high blood glucose levels during pregnancy, which affects foetal and post-natal development. However, the cellular and molecular mechanisms of ...
-
(Impact Journals Llc., 2017)Basal Cell Carcinoma (BCC) is one of the most diagnosed cancers worldwide. It develops due to an unrestrained Sonic Hedgehog (SHH) signaling activity in basal cells of the skin. Certain subtypes of BCC are more aggressive ...
-
(Springer, 2010)We investigate the performance of one stretched-grid atmospheric global model, five different regional climate models and a statistical downscaling technique in simulating 3 months (January 1971, November 1986, July 1996) ...
-
(American Chemical Society, 2020)A new lasso peptide, huascopeptin, was isolated following genome-mined discovery of a new biosynthetic gene cluster in extremotolerant Streptomyces huasconensis HST28(T) from Salar de Huasco, Atacama Desert, Chile. Compound ...
-
(Universidad de Chile, 2021)Las redes sociales, los dispositivos móviles y las grandes compañías que se han levantado junto con las aplicaciones digitales, han modificado las formas en que accedemos a la información. En los inicios de internet, una ...
-
(Universidad de Chile, 2021)La limpia de canales o Talatur es un ritual precolombino que hasta el día de hoy se realiza por las comunidades originarias en la zona sur del Salar de Atacama. Se destaca por sus aspectos culturales y sociales, donde se ...
-
(Universidad de Chile., 2021)La urbanización es la actividad humana que causa las mayores tasas de extinción local de biodiversidad. El cambio de uso de suelo impacta negativamente el hábitat de distintas especies nativas. También causa homogeneización ...
-
(Universidad de Chile, 2023)
-
(Universidad de Chile, 2022)
-
(Universidad de Chile, 2007)
-
(Universidad de Chile, 2019-12)La presente memoria consiste en un estudio cualitativo de casos, sobre ocho mujeres lesbianas -jóvenes, estudiantes universitarias o profesionales, residentes de diferentes comunas de Santiago-, cuyo objetivo fue describir ...
-
(Instituto de la Vivienda, Facultad de Arquitectura y Urbanismo, Universidad de Chile, 2014-08)La capacidad de conceptualizar el hábitat residencial está ligada a la forma de problematizarlo. Es de este modo que tradicionalmente se ha optado por un enfoque físico-espacial, relacionado a la constitución material y ...
-
(PERGAMON-ELSEVIER SCIENCE LTD, 2008-03)Numerous investigations exist about the alterations that oxygen free radicals can provoke on biomolecules; these modifications can be prevented and/or reversed by different antioxidants agents. On the other hand, ...
-
(MDPI AG, 2015)HLA-linked genes are relevant to celiac disease (CD); the potential genetic differences present worldwide are not fully understood. Previous results suggest that the distribution of HLA-DQ2/DQ7/DQ8 in Chile may differ from ...