Browsing by Author "Lavandero González, Sergio"

Now showing items 41-60 of 312

    • Ca2+ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells 
      Li, Q.; Zhu, X.; Ishikura, S.; Zhang, D.; Gao, J.; Sun, Y.; Contreras Ferrat, Ariel Eduardo; Foley, K. P.; Lavandero González, Sergio; Yao, Z.; Bilan, P. J.; Klip, A.; Niu, W. (American Physiological Society, 2014)
      Ca2+ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells. Am J Physiol Endocrinol Metab 307: E209–E224, 2014. First published June 3, 2014; doi:10.1152/ajpendo.00045.2014.— Elevating cytosolic ...
    • Ca2+ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells 
      Li, Q.; Zhu, X.; Ishikura, S.; Zhang, D.; Gao, J.; Sun, Y.; Contreras Ferrat, Ariel Eduardo; Foley, K. P.; Lavandero González, Sergio; Yao, Z.; Bilan, Philip J.; Klip, Amira; Niu, W. (American Physiological Society, 2014)
      Elevating cytosolic Ca2+ stimulates glucose uptake in skeletal muscle, but how Ca2+ affects intracellular traffic of GLUT4 is unknown. In tissue, changes in Ca2++ leading to contraction preclude analysis of the impact of ...
    • Ca2+, autophagy and protein degradation: Thrown off balance in neurodegenerative disease 
      Vicencio, José Miguel; Lavandero González, Sergio; Szabadkai, Gyorgy (ELSEVIER, 2010)
      Substantial progress has been made throughout the last decades in the elucidation of the key players and mechanisms responsible for Ca2+ signal generation in both excitable and non-excitable cells. Importantly, these ...
    • Ca2+/ Calmodulin dependent protein kinase II and androgen signaling pathways modulate MEF2 activity in ... 
      Durán, Javier; Lagos, Daniel; Pavez, Mario; Troncoso, Mayarling F.; Ramos, Sebastián; Barrientos Briones, Genaro; Ibarra, Cristián; Lavandero González, Sergio; Estrada Hormazábal, Manuel (Frontiers media SA, 2017)
      Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has ...
    • Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death 
      Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Calcium sensing receptor as a novel mediator of adipose tissue dysfunction: mechanisms and potential clinical ... 
      Bravo Sagua, Roberto; Mattar, Pamela; Díaz, Ximena; Lavandero González, Sergio; Cifuentes, Mariana (Frontiers Media, 2016)
      Obesity is currently a serious worldwide public health problem, reaching pandemic levels. For decades, dietary and behavioral approaches have failed to prevent this disease from expanding, and health authorities are ...
    • Calcium signaling in insulin action on striated muscle 
      Contreras Ferrat, Ariel Eduardo; Lavandero González, Sergio; Jaimovich Pérez, Enrique; Klip, Amira (Churchill Livingstone, 2014)
      © 2014 Elsevier Ltd. Striated muscles (skeletal and cardiac) are major physiological targets of insulin and this hormone triggers complex signaling pathways regulating cell growth and energy metabolism. Insulin increases ...
    • Calcium transport and signaling in mitochondria 
      Bravo Sagua, Roberto; Parra Ortíz, María Valentina; López Crisosto, Camila; Díaz, Paula; Quest, Andrew F. G.; Lavandero González, Sergio (Wiley, 2017-04)
      Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ...
    • Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy 
      Mattar, Pamela; Pino Sanhueza, Sofía Carolina; Yuri, Gabriela; Briones, Lautaro; Pérez Leighton, Claudio; Rudich, Assaf; Lavandero González, Sergio; Cifuentes Koster, Mariana (MDPI, 2020)
      Autophagy is upregulated in adipose tissue (AT) from people with obesity. We showed that activation of the calcium-sensing receptor (CaSR) elevates proinflammatory cytokines through autophagy in preadipocytes. Our aim is ...
    • Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion 
      Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Caracterización clínica de pacientes sometidos a cirugía coronaria y relación de carbonilación de proteínas ... 
      Solís Mitre, Margarita Alejandra (Universidad de Chile, 2010)
      La fibrilación auricular (FA) es una arritmia rápida e irregular que se puede presentar como una complicación post-operatoria en pacientes que se han sometido a cirugía cardiaca. La presencia de FA disminuye la calidad de ...
    • Cardiac Plasticity in Health and Disease 
      Gondalia, Raj B.; Rothermel, Beverly A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Springer Science+Business Media, 2012)
    • Cardiomyocyte death: Mechanisms and translational implications 
      Chiong Lay, Mario; Wang, Z. V.; Pedrozo Cibils, Zully; Cao, D. J.; Troncoso, R.; Ibacache, M.; Criollo, A.; Nemchenko, A.; Hill, J. A.; Lavandero González, Sergio (2011)
      Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, ...
    • Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy 
      Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by ... 
      Davidson, Sean M.; Riquelme, Jaime A.; Takov, Kaloyan; Vicencio, José M.; Boi-Doku, Claire; Khoo, Vanessa; Doreth, Christian; Radenkovic, Dina; Lavandero González, Sergio; Yellon, Derek M. (Blackwell, 2018)
      Many patients with ischaemic heart disease also have diabetes. As myocardial infarction is a major cause of mortality and morbidity in these patients, treatments that increase cell survival in response to ischaemia and ...
    • Cardiotoxicidad inducida por tratamientos oncológicos. Fundamentos para la implementación de equipos de ... 
      Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana M.; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sanchez, Cesar; Pizarro, Marcela; Corvalan, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martinez, Gonzalo (Sociedad Médica de Santiago, 2018-01)
      Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, these new therapies, along with greater patient survival, ...
    • Cardiotoxicidad por doxorrubicina : efecto sobre la autofagia basal 
      Pizarro Barahona, Marcela Beatriz (Universidad de Chile, 2016)
      Doxorrubicina es un efectivo agente quimioterápico ampliamente utilizado en el tratamiento de diversos tipos de cáncer. Sin embargo, su cardiotoxicidad es el principal factor limitante y puede presentarse como una ...
    • Cardiotoxicity of anticancer therapies. Towards the implementation of cardio-oncology units Cardiotoxicidad ... 
      Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana María; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sánchez, César; Pizarro, Marcela; Corvalán, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martínez, Gonzalo (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, ...
    • Cardiovascular autophagy concepts, controversies, and perspectives 
      Lavandero González, Sergio; Troncoso Cotal, Rodrigo; Rotherme, Beverly; Martinet, Wim; Sadoshima, Junichi; Hill, Joseph (Taylor and Francis Inc., 2013)
      Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been ...
    • Carvedilol corrects interventricular and interventricular dyssynchrony in chronic heart failure. 
      Castro, Pablo; Mc-Nab, Pablo; Bittner, Alex; Greig, Douglas; Quintana, Juan Carlos; Chiong Lay, Mario; Díaz Araya, Guillermo; Valenzuela, Rodrigo; Vergara, I.; Corbalán, Ramón; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2005-02-01)
      Meeting Abstract