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Calcium transport and signaling in mitochondria

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2017-04
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Bravo Sagua, Roberto
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Calcium transport and signaling in mitochondria
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Author
  • Bravo Sagua, Roberto;
  • Parra Ortíz, María Valentina;
  • López Crisosto, Camila;
  • Díaz, Paula;
  • Quest, Andrew F. G.;
  • Lavandero González, Sergio;
Abstract
Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ubiquitous nature, the regulation of both is deeply intertwined, whereby Ca2+ regulates mitochondrial functions, while mitochondria shape Ca2+ dynamics. Deregulation of either Ca2+ or mitochondrial signaling leads to abnormal function, cell damage or even cell death, thereby contributing to muscle dysfunction or cardiac pathologies. Moreover, altered mitochondrial Ca2+ homeostasis has been linked to metabolic diseases like cancer, obesity, and pulmonary hypertension. In this review article, we summarize the mechanisms that coordinate mitochondrial and Ca2+ responses and how they affect human health.
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Fondo Nacional de Desarrollo Cientifico y Tecnologico, FONDECYT, Chile 3160226 1161156 1130250 11150282 FONDAP 15130011 PAI Insertion Program 79150007 CONICYT
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Artículo de publicación ISI
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URI: https://repositorio.uchile.cl/handle/2250/146971
DOI: 10.1002/cphy.c160013
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Comprehensive Physiology Volumen:7 Número:2 Páginas: 623-634 (2017)
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