Browsing by Author "Chiong Lay, Mario"

Now showing items 81-100 of 123

    • Niveles de angiotensina (1-7) en ratas con distinto genotipo de enzima convertidora de angiotensina I y ... 
      Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2003)
      La mayor actividad de la enzima convertidora de angiotensina I (ECA) determina mayores niveles de angiotensina (Ang) II y menores de Ang-(1-7). Hemos observado mayores niveles de Ang II en ratas normotensas con mayor ...
    • Novel insights into the pathogenesis of diabetic cardiomyopathy and pharmacological strategies 
      Muñoz Córdova, Felipe Andrés; Hernández Fuentes, Carolina; López Crisosto, Camila; Troncoso, Mayarling; Calle Chalco, Ximena Elena; Guerrero Moncayo, Alejandra; Gabrielli, Luigi; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Frontiers Media, 2021)
      Diabetic cardiomyopathy (DCM) is a severe complication of diabetes developed mainly in poorly controlled patients. In DCM, several clinical manifestations as well as cellular and molecular mechanisms contribute to its ...
    • Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) 
      Westermeier, Francisco; Bustamante, Mario; Pavez, Mario; García Nannig, Lorena; Chiong Lay, Mario; Ocaranza, María Paz; Lavandero González, Sergio (Elsevier, 2015)
      Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 
      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes 
      Navarro, Paola; Chiong Lay, Mario; Volkwein, Karen; Moraga, Francisco; Ocaranza, María Paz; Jalil Milad, Jorge; Sun, Woo Lim; Jeong-Ah, Kim; H., Moo Kwon; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-07-25)
      Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanisms may, therefore, play a crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key ...
    • Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium ... 
      Díaz Araya, Guillermo; Nettle Danniels, Maurice; Castro Agüero, Pablo; Miranda, Fernando; Greig, Douglas; Campos Bastidas, Ximena; Chiong Lay, Mario; Nazal N., Carolina; Corbalán, Ramón; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-02)
      Objective: To evaluate the oxidative stress status and the modification with glucose-insulin-potassium (GIK) therapy in patients with acute myocardial infarction undergoing primary percutaneous transluminal coronary ...
    • Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives Estrés ... 
      Miranda H, Rodrigo; Castro G, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rosemarie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (2007)
      Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a ...
    • Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives. ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rose Marie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2007-08)
      Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a ...
    • Oxidative stress in pericardial fluid and plasma and its association with ventricular function 
      Vukasovic Ramírez, José Luis; Moraga, Francisco; Díaz Araya, Guillermo; Turner, Eduardo; Chiong Lay, Mario; Uriarte, Polientzi; Florenzano Urzúa, Fernando; Lavandero González, Sergio (ELSEVIER IRELAND LTD, 2005-05-25)
      There are no studies evaluating oxidative stress markers both in pericardial fluid and plasma and whether they correlate with cardiac function indexes. The purpose of the study was to investigate whether oxidative stress ...
    • Papel del calcio mitocondrial en el remodelado del cardiomiocito inducido por IGF-1 
      Sánchez Aguilera, Pablo Ignacio (Universidad de Chile, 2022)
      Introducción: La hipertrofia cardiaca adaptativa o fisiológica es la respuesta del corazón para adaptar su función y estructura frente a estímulos fisiológicos, incluidos el ejercicio y el embarazo. Recientemente, se ...
    • Papel del factor transcripcional TonEBP en el daño cardíaco inducido por hiperosmolaridad 
      Chiong Lay, Mario (Universidad de Chile, 2009)
      TonEBP, la proteína que se une al elemento regulatorio que responde a tonicidad “TonE” es el único factor transcripcional conocido de eucariontes que responde a cambios de la osmolaridad extracelular. Este factor transcripcional ...
    • Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced ... 
      Chiong Lay, Mario; Parra, V.; Eisner, V.; Ibarra, C.; Maldonado, C.; Criollo Céspedes, Alfredo; Bravo, R.; Quiroga, C.; Contreras, A.; Vicencio Bustamante, José; Cea, P.; Bucarey, J.; Molgó, Jordi; Jaimovich Pérez, Enrique; Hidalgo Tapia, María Cecilia; Kroemer, G.; Lavandero González, Sergio (2010)
      Hyperosmotic stress promotes rapid and pronounced apoptosis in cultured cardiomyocytes. Here, we investigated if Ca2+ signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] ...
    • Participación de la autofagia en la inducción del fenotipo sintético por TNF-[alfa] en células musculares ... 
      García Miguel, Marina (Universidad de Chile, 2016)
      Antecedentes y objetivo: La aterosclerosis se caracteriza por una desdiferenciación las células de músculo liso vascular (VSMC) a un fenotipo migratorio, proliferativo, con baja expresión de proteínas de contracción y una ...
    • Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart ... 
      Pérez, Osvaldo; Castro Agüero, Pablo; Díaz Araya, Guillermo; Nettle Nettle, Daniels Maurice; Moraga, Francisco; Chiong Lay, Mario; Jalil Milad, Jorge; Zalaquett Sepúlveda, Ricardo; Morán, Sergio; Becker, Pedro; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2002-08)
      Introduction and objective. Chronic heart failure (CHF) is associated with oxidative stress. Heart transplantation, an important therapeutic alternative in these patients, could reduce oxidative stress by improving cardiac ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial ... 
      Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Polimorfismos de los receptores - β Adrenérgicos y su relación con el riesgo de insuficiencia cardíaca, ... 
      Castro Gálvez, Pablo; Greig, Douglas; Copaja, Miguel; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Mellado, Rose Marie; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Corbalán, Ramón; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio (Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)
      Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
    • Reactive oxygen species inhibit hyposmotic stress-dependent volume regulation in cultured rat cardiomyocytes 
      Díaz Elizondo, Jessica; Chiong Lay, Mario; Rojas Rivera, Diego; Olea Azar, Claudio; Kwon, H. Moo; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-12-01)
      Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells ...
    • Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system 
      Ocaranza, María Paz; Michea Acevedo, Luis; Chiong Lay, Mario; Lagos, Carlos F.; Lavandero González, Sergio; Jalil Milad, Jorge (Portland Press Ltd, 2014)
      Chronic RAS (renin-angiotensin system) activation by both AngII (angiotensin II) and aldosterone leads to hypertension and perpetuates a cascade of pro-hypertrophic, pro-inflammatory, pro-thrombotic and atherogenic effects ...
    • Regulación de la autofagia por GLP-1 en células musculareslisas vasculares (VSMC) 
      Núñez Soto, Constanza Belén (2017)
      Las enfermedades cardiovasculares son la primera causa de muerte en el mundo. Desregulaciones en el flujo autofágico y en la desdiferenciación de células musculares lisas vasculares (VSMC) se han asociado con diferentes ...