Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)
MetadataShow full item record
Cómo citarNovel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)
Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell death) and, conversely, its deficiency is associated with impaired cardiac function. Recently, we reported that insulin like growth factor-1 receptor is also located in plasma membrane invaginations with perinuclear localization, highlighting the role of nuclear Ca2+ signaling in the heart. In parallel, angiotensin-(1-7) and angiotensin (1-9) acting through Mas receptor and angiotensin type 2 receptor have emerged as a novel anti-hypertensive molecules promoting vasodilatation and preventing heart hypertrophy. In this review we discuss the scientific evidence available regarding insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) in cardioprotection and its potential application as novel therapeutic targets for treating cardiac diseases. (c) 2015 Elsevier Ltd. All rights reserved.
Artículo de publicación ISI
Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile; FONDEF; Anillo; FONDECYT; CONICYT
DOI: DOI: 10.1016/j.phrs.2015.06.018
Quote ItemPharmacological Research 101 (2015) 41–55
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile
Showing items related by title, author, creator and subject.
Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme ... Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
Regulatory role of angiotensin II on progesterone production by cultured human granulosa cells. Expression ... Johnson, M. C.; Vega Blanco, María Margarita; Vantman, D.; Troncoso, J. L.; Devoto, Luigi (1997)The role of angiotensin II (Angll) in ovarian steroidogenesis is not clearly understood. In order to study its action on progesterone synthesis and to determine which receptor subtype is involved, granulosa cells obtained ...
Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in ... Ocaranza, María Paz; Rivera, Paulina; Novoa, Ulises; Pinto, Melissa; González, Leticia; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2011-04)Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho ...