Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)
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Westermeier, Francisco
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Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9)
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Abstract
Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell death) and, conversely, its deficiency is associated with impaired cardiac function. Recently, we reported that insulin like growth factor-1 receptor is also located in plasma membrane invaginations with perinuclear localization, highlighting the role of nuclear Ca2+ signaling in the heart. In parallel, angiotensin-(1-7) and angiotensin (1-9) acting through Mas receptor and angiotensin type 2 receptor have emerged as a novel anti-hypertensive molecules promoting vasodilatation and preventing heart hypertrophy. In this review we discuss the scientific evidence available regarding insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) in cardioprotection and its potential application as novel therapeutic targets for treating cardiac diseases. (c) 2015 Elsevier Ltd. All rights reserved.
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Comision Nacional de Ciencia y Tecnologia (CONICYT), Chile; FONDEF; Anillo; FONDECYT; CONICYT
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URI: https://repositorio.uchile.cl/handle/2250/136047
DOI: DOI: 10.1016/j.phrs.2015.06.018
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Pharmacological Research 101 (2015) 41–55
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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile
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