Browsing by Author "Díaz Araya, Guillermo"

Now showing items 81-100 of 118

    • A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes 
      Galvis Pareja, David; Zapata Torres, Gerald; Hidalgo Tapia, Jorge; Ayala, Pedro; Pedrozo Cibils, Zully; Ibarra, Cristián; Díaz Araya, Guillermo; Hall, Andrew R.; Vicencio, José Miguel; Núñez Vergara, Luis; Lavandero González, Sergio (Elsevier, 2014)
      Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
    • Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium ... 
      Díaz Araya, Guillermo; Nettle Danniels, Maurice; Castro Agüero, Pablo; Miranda, Fernando; Greig, Douglas; Campos Bastidas, Ximena; Chiong Lay, Mario; Nazal N., Carolina; Corbalán, Ramón; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-02)
      Objective: To evaluate the oxidative stress status and the modification with glucose-insulin-potassium (GIK) therapy in patients with acute myocardial infarction undergoing primary percutaneous transluminal coronary ...
    • Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives Estrés ... 
      Miranda H, Rodrigo; Castro G, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rosemarie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (2007)
      Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a ...
    • Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives. ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rose Marie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2007-08)
      Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a ...
    • Oxidative stress in pericardial fluid and plasma and its association with ventricular function 
      Vukasovic Ramírez, José Luis; Moraga, Francisco; Díaz Araya, Guillermo; Turner, Eduardo; Chiong Lay, Mario; Uriarte, Polientzi; Florenzano Urzúa, Fernando; Lavandero González, Sergio (ELSEVIER IRELAND LTD, 2005-05-25)
      There are no studies evaluating oxidative stress markers both in pericardial fluid and plasma and whether they correlate with cardiac function indexes. The purpose of the study was to investigate whether oxidative stress ...
    • Papel de la policistina-1 en la regulación de la expresión de c-Myc y BIN1 en los cardiomiocitos 
      Poblete Guzmán, Felipe Ignacio (Universidad de Chile, 2020)
      La Policistina-1 (PC1) es un mecanosensor fundamental para la correcta contractilidad cardiaca y su ausencia en los cardiomiocitos se relaciona con la disminución de los niveles proteicos de los canales de calcio tipo-L ...
    • Participación de EPAC en procesos de adhesión, migración y contracción de geles de colágeno en fibroblastos ... 
      Guzmán Muñoz, Nancy Alejandra (Universidad de ChileCyberDocs, 2011)
      El corazón está constituido por numerosos tipos celulares, de los cuales el 90% corresponde a cardiomiocitos y fibroblastos. Los fibroblastos representan dos tercios de la población celular del corazón y están encargados ...
    • Participación de la vía GSK3-[beta]/NFAT en la hipertrofia inducida por testosterona del cardiomiocito de ... 
      Oyarce Díaz, César Israel (Universidad de ChileCyberDocs, 2011)
      El uso de elevadas dosis de testosterona produce hipertrofia cardiaca, sin embargo los mecanismos celulares no son completamente entendidos. La proteína quinasa GSK3-β (glycogen synthase kinase 3-β) es una quinasa que ...
    • Perindopril regulates beta-agonist-induced cardiac apoptosis 
      Gálvez, A. S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2005-09)
      Administration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Perindopril regulates β-agonist-induced cardiac apoptosis 
      Gálvez, Anita S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (2005)
      Administration of the β-adrenergic agonist isoproterenol results in cardiac apoptosis, The effect of short-term β-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart ... 
      Pérez, Osvaldo; Castro Agüero, Pablo; Díaz Araya, Guillermo; Nettle Nettle, Daniels Maurice; Moraga, Francisco; Chiong Lay, Mario; Jalil Milad, Jorge; Zalaquett Sepúlveda, Ricardo; Morán, Sergio; Becker, Pedro; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2002-08)
      Introduction and objective. Chronic heart failure (CHF) is associated with oxidative stress. Heart transplantation, an important therapeutic alternative in these patients, could reduce oxidative stress by improving cardiac ...
    • Pharmacological blockade of NLRP3 inflammasome/IL1β-positive loop mitigates endothelial cell senescence and ... 
      Romero, Alejandra; Dongil, Pilar; Valencia, Inés; Vallejo, Susana; San Hipólito Luengo, Álvaro; Díaz Araya, Guillermo; Bartha, José L.; González Arlanzón, María M.; Rivilla, Fernando; Cuesta, Fernando de la; Sánchez Ferrer, Carlos; Peiró, Concepción (International Society on Aging and Disease, 2022)
      The clinical relevance of IL-1 beta in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition of the cytokine with lower cardiovascular risk. Previously, ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Polimorfismos de los receptores - β Adrenérgicos y su relación con el riesgo de insuficiencia cardíaca, ... 
      Castro Gálvez, Pablo; Greig, Douglas; Copaja, Miguel; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Mellado, Rose Marie; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Corbalán, Ramón; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio (Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)
      Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
    • Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Carreño, J. E.; Muñoz, David; Riveros, Juan Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (AMER PHYSIOLOGICAL SOC, 2004-02-01)
      In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
    • A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes 
      Gálvez, Anita; Morales, María Paz; Eltit Ortega, José Miguel; Ocaranza, María Paz; Carrasco Alarcón, Loreto del Pilar; Campos Bastidas, Ximena; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (SPRINGER-VERLAG, 2001-05)
      In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
    • Regulación del estrés oxidativo, inflamación, remodelamiento cardiovascular y función endotelial por ... 
      Bustos Contreras, Carlos Andrés (Universidad de ChilePrograma Cybertesis, 2007)
      La insuficiencia cardíaca (IC) es un síndrome clínico complejo que se caracteriza por una disfunción del ventrículo, ya que impide que el corazón se llene y expulse la sangre necesaria para suplir los requerimientos ...
    • Regulation of autophagy by Insulin/IGF-1 signaling pathways 
      Troncoso, Rodrigo; Vásquez Trincado, César; Campo, Andrea del; Gatica, Damián; Morales, Pablo; Paredes, Felipe; Gutiérrez, Tomás; López Crisosto, Camila; Lavandero González, Sergio; Torrealba, Natalia; García Nannig, Lorena; Díaz Araya, Guillermo; Battiprolu, Pavan K.; Nemchenko, Andriy; Ferdous, Anwarul; Gillette, Thomas G.; Hill, Joseph A. (Nova Science Publishers, 2012)
    • Regulation of Cardiac Autophagy by Insulin-like Growth Factor 1 
      Troncoso, Rodrigo; Díaz Elizondo, Jessica; Espinoza, Sandra P.; Navarro Márquez, Mario F.; Oyarzún, Alejandra P.; Riquelme, Jaime A.; García Carvajal, Ivonne; Díaz Araya, Guillermo; García Nannig, Lorena; Hill, Joseph A.; Lavandero González, Sergio (2013-07)
      Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase ...
    • Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients ... 
      Castro, Pablo; Greig, Douglas; Pérez, Osvaldo; Moraga, Francisco; Chiong Lay, Mario; Díaz Araya, Guillermo; Padilla, Ivonne; Nazzal Nazal, Carolina; Jalil Milad, Jorge; Vukasovic Ramírez, José Luis; Moreno, M.; Corbalán, Ramón; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-07-15)