Now showing items 9276-9295 of 92854

    • Lavandero González, Sergio; Chiong Lay, Mario; Rothermel, Beverly A.; Hill, Joseph A. (American Society for Clinical Investigation, 2015)
      Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing ...
    • Hazari, Younis M.; Bravo San Pedro, José Manuel; Hetz Flores, Claudio; Galluzzi, Lorenzo; Kroemer, Guido (Elsevier, 2020)
      Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence ...
    • Mattar, Pamela; Bravo Sagua, Roberto; Tobar, Nicolás; Fuentes, Cecilia; Troncoso, Rodrigo; Breitwieser, Gerda; Lavandero González, Sergio; Cifuentes, Mariana (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails. The development of obesity-related cardiometabolic disorders is in direct ...
    • García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public library science, 2018)
      Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
    • Matus, Soledad; Bosco, Daryl A.; Hetz Flores, Claudio (Elsevier, 2014)
      Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures ...
    • Paris Pizarro, Irmgard; Muñoz, Patricia; Huenchuguala, Sandro; Couve, Eduardo; Sanders, Laurie H.; Greenamyre, John Timothy; Caviedes, Pablo; Segura Aguilar, Juan (2011)
      Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
    • Silva, Victor D.A.; Urriola Cuevas, Carlos; Muñoz, Patricia; Villa, Monica; Ahumada-Castro, Ulises; Huenchuguala, Sandro; Dos Santos, Cleonice C.; De Araujo, Fillipe M.; Ferreira, Rafael; Da Silva, Vanessa B.; Silva, Juliana H.C.; Soares, Érica N.; Velozo, Eudes S.; Segura Aguilar, Juan (Academia Brasileira de Ciencias, 2017)
      © 2017, Academia Brasileira de Ciencias. All rights reserved. Prosopis juliflora is a shrub that has been used to feed animals and humans. However, a synergistic action of piperidine alkaloids has been suggested to be ...
    • Budini, Mauricio; Jacob, Germaine; Jedlicki, Ana; Pérez, Carolina; Allende, Catherine C.; Allende, Jorge E. (2009)
      CK1 constitutes a protein kinase subfamily that is involved in many important physiological processes. However, there is limited knowledge about mechanisms that regulate their activity. Isoforms CK1δ and CKlε were previously ...
    • López Azócar, Víctor Antonio (Universidad de Chile, 2023)
    • Varela,; Maturana, Daniel; Uribe, (1974)
      We formulate the organization of living organisms through the characterization of the class of autopoietic systems to which living things belong. This general characterization is seen at work in a computer simulated model ...
    • Arnold Cathalifaud, Marcelo (Universidad de Chile. Departamento de Antropología, 2003-09)
      En este artículo se plantea la tesis que los procesos de diferenciación funcional, aunque refuerzan estructuralmente la viabilidad del sistema societal global y sus parcialidades, dejan espacios rezagados y de alta fragilidad ...
    • Silva Rivas, Fernando Wladimir (Universidad de Chile, 2012)
      A pesar del carácter histórico del conflicto entre el Estado de Chile y el Pueblo Mapuche, los cambios en la estructura de la sociedad, como la diferenciación funcional y la consolidación de una sociedad mundial, afectaron ...
    • Orellana Fernández, Rocío (Universidad de Chile, 2005)
      Abarcando todos los criterios, ciencias y creencias, el “azar” ha estado en algún momento presente. Desde tiempos inmemoriables, el hombre ha experimentado, creyendo en sí mismo y creando cosas que aparecen sin ser pensadas ...
    • Tapia Castillo, Cristina (Universidad de Chile, 1935)
    • Crain, Barbara J.; Valdes, Fernando; Chang, Kwen Jen; McNamara, James O. (1985)
      The benzomorphan subpopulation of opiate binding sites was labeled by [3H]diprenorphine in the presence of unlabeled ligands selected to quench μ and δ opiate binding sites. The distribution of benzomorphan binding sites ...
    • Fernandez, Virginia; Bravo, Roberto (1974)
      The histogenetic development of the archi, paleo and neocortex of the rabbit was studied using autoradiographic techniques. The analysis is based upon a series of 54 embryos and newborn rabbits, whose mothers were injected ...
    • Fernández, Víctor; Bravo, Hermes; Kuljis, Rodrigo; Fuentes, Irma (1979)
      Autoradiographic labelling has been employed to analyze the morphogenesis of the neostriatum. Pregnant rabbits received a single intraperitoneal injection of tritiated thymidine at different stages of gestation. Careful ...
    • Tchernitchin Varlamov, Andrés (1967)
      (6,7-3H) oestradiol-17β incorporation by the rat uterus has been studied using autoradiography. The cytoplasm and/or the cellular membrane of uterine eosinophilic cells seems to incorporate oestradiol in a much greater ...