Browsing by Author "Bono Merino, María Rosa"
Now showing items 1-20 of 78
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(Frontiers Media, 2021)Insufficient oxygen supply represents a relevant issue in several fields of human physiology and medicine. It has been suggested that the implantation of photosynthetic cells can provide oxygen to tissues in the absence ...
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(Universidad de Chile, 2019)Dendritic cells (DCs) have emerged as attractive candidates in the cancer immunotherapy field due to their high plasticity and the capacity to regulate adaptive immunity. As a major organelle responsible of protein ...
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(Universidad de ChileCyberDocs, 2008)La migración de los linfocitos a los órganos linfoides secundarios es un paso crucial en la iniciación de la respuesta inmune adquirida. Este fenómeno es caracterizado por múltiples eventos que requieren de interacciones ...
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Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells (ELSEVIER SCIENCE INC, 2008-11)Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection ...
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(Frontiers Media, 2015)The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction ...
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(Wiley-Blackwell, 2015)CD4+CD25+Foxp3+ regulatory T (Treg) cells mediate immunological self-tolerance and suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has been reported to enhance the differentiation of ...
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(2013)Background: An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection. Aim: To quantify pro-inflammatory cytokines (IL-6-IL-8, IL-1-β and TNF-α) in nasopharyngeal ...
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(Universidad de Chile, 2008)
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(PLoS ONE, 2013)The Ca2+-activated Cl2 channel is considered a key constituent of odor transduction. Odorant binding to a specific receptor in the cilia of olfactory sensory neurons (OSNs) triggers a cAMP cascade that mediates the opening ...
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(Universidad de Chile, 2012)Las enfermedades inflamatorias intestinales (EII) se caracterizan por presentar una respuesta inmune intestinal exagerada frente a los antígenos de la dieta o a la microbiota. Entre las EII destacan la colitis ulcerosa ...
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(Universidad de Chile, 2019-08)El Lupus Eritematoso Sistémico (LES) es una enfermedad autoinmune caracterizada por la hiperactividad de células T y B autorreactivas, la producción de autoanticuerpos y la formación de complejos inmunes que terminan ...
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(Elsevietr, 2015)Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
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(Frontiers Media, 2021)CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
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(Wiley & Sons, 2015)The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
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(SOC BIOLGIA CHILE, 2010-08-12)One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
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(ELSEVIER, 2003-11)The mode of action of cyclosporine (CsA) has been ascribed to its capacity to inhibit IL-2 and IFNgamma production by T cells, two cytokines implicated in allograft rejection. Recently, it has been reported that upon ...
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(2013)Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increase in the percentage of autoreactive B and T lymphocytes. Since dendritic cells (DCs) are essential for B cell and T cell function, ...
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(ELSEVIER, 2010)Background. CD4 CD25 Foxp3 regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression ...
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(Universidad de Chile, 2023)Los linfocitos T CD8+ son células del sistema inmune adaptativo que, una vez activadas por células presentadoras de antígenos, se diferencian a células citotóxicas cumpliendo un rol importante en la respuesta inmune ...
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(The American Association of Immunologists, Inc., 2010)Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss ofimmune ...
