Browsing by Author "201-0372327"
Now showing items 21-40 of 55
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Aliaga, Margarita E.; Carrasco Pozo, Catalina; López Alarcón, Camilo; Speisky Cosoy, Hernán (Springer, 2010)Cu2? ions and reduced glutathione (GSH) swiftly interact to form the physiologically occurring Cu(I)–[GSH]2 complex. Prompted by the recently reported ability of this complex to generate superoxide radicals from molecular ...
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Sandoval Acuña, Cristian; Fuentes Retamal, Sebastián; Guzmán Rivera, Daniela; Peredo Silva, Liliana; Madrid Rojas, Matías; Rebolledo, Solange; Castro Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya Arango, Juan; Jara, Jose A.; Parra, Eduardo; Calaf, Gloria M.; Speisky Cosoy, Hernán; Ferreira Parker, Jorge (2016)Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
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Henríquez, Carolina; Speisky Cosoy, Hernán; Chiffelle, Italo; Valenzuela, Tania; Araya, Manuel; Simpson, Ricardo; Almonacid, Sergio (2010)Apple peel is a waste product from dried apple manufacture. The content of phenolic compounds, dietary fiber, and mineral are higher in apple peel, compared to other edible parts of this fruits. The objective of this study ...
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Carrasco Pozo, Catalina; Mizgier, María Luisa; Speisky Cosoy, Hernán; Gotteland, Martín (Elsevier, 2012)The beneficial effects of dietary polyphenols on health are due not only to their antioxidant properties but also to their antibacterial, anti-inflammatory and/or anti-tumoral activities. It has recently been proposed that ...
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Carrasco Pozo, Catalina; Aliaga, Margarita E.; Olea Azar, Claudio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER, 2008-11-15)The present study investigated the redox-consequences of the interaction between various endogenous thiols (RSH)-glutathione, cysteine, homocysteine, c-glutamyl-cysteine, and cysteinyl-glycine-and Cu2+ ions, in terms of ...
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Loghin, Felicia; Chagraoui, Abdeslam; Asencio, Marcelo; Comoy, Etienne; Speisky Cosoy, Hernán; Cassels Niven, Bruce; Protais, Philippe (Elsevier, 2003)(S)-(+)-boldine, an aporphine alkaloid displaying antioxidative and dopaminergic properties, and six of its derivatives (glaucine, 3-bromoboldine, 3-iodoboldine, 8-aminoboldine, 8-nitrosoboldine and 2,9-O,O′-dipivaloylboldine) ...
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Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
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Méndez, Eduardo; Sanhueza, Julio; Nieto, Susana; Speisky Cosoy, Hernán; Valenzuela Bonomo, Carlos (1998)The oil extracted from the fat-storage organ (fat body) of the bullfrog (Rana catesbeiana) was characterized for its fatty acid composition. The main fatty acids were palmitic (18.1%), stearic (4.1%), myristic (2.7%), oleic ...
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Rincón Cervera, Miguel Ángel; Galleguillos Fernández, Raúl; González Barriga, Barriga; Valenzuela Báez, Rodrigo; Speisky Cosoy, Hernán; Fuentes, Jocelyn; Valenzuela, Alfonso (Wiley, 2020)
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Aguilera Venegas, Benjamín; Speisky Cosoy, Hernán (Elsevier Inc., 2014)Up to date, attempts to locate the transition state (TS) for the trapping reaction between ̇OH and ̇DMPO have been unsuccessful, and the lack of molecular mechanisms by which ̇OH binds to the spin-trap constitutes a question ...
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Carrasco Pozo, Catalina; Álvarez Lueje, Alejandro; Olea Azar, Claudio; López Alarcón, Camilo; Speisky Cosoy, Hernán (SOC EXPERIMENTAL BIOLOGY MEDICINE, 2006-10)Homocysteine (Hcys) has been implicated in various oxidative stress–related disorders. The presence of a thiol on its structure allows Hcys to exert a double-edge redox action. Depending on whether Cu2þions occur ...
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López Alarcón, Camilo; Lissi, E.; Hoffmann, P.; Mella, J.; Pessoa Mahana, Carlos David; Speisky Cosoy, Hernán; Möller, M.; Ferrer-Sueta, G.; Denicola, A. (2011)The reaction of 5-aminosalicylic acid (5-ASA) with nitrous acid has been studied at low pH under conditions that simulate a gastric environment. The course of the reaction was followed by UV-visible and fluorescence ...
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International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their ... Bridi, Raquel; Montenegro, Gloria; Núñez Quijada, Gabriel; Giordano, Ady; Morán Romero, María Fernanda; Jara Pezoa, Isaac; Speisky Cosoy, Hernán; Atala, Elías; López Alarcón, Camilo (Institute of Food Technologists, 2015)Propolis has been proposed as a polyphenolic-rich natural product potentially able to be used for human consumption or even for medicinal proposes. To guarantee a minimum phenolic and flavonoid content and as consequence ...
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Jiménez, I.; Gotteland, M.; Zarzuelo, A.; Uauy Dagach-Imbarack, Ricardo; Speisky Cosoy, Hernán (1997)The relationship between the metal-binding properties of metallothionein (MT) and its ability to interact with peroxides and free radicals was explored in vitro. The binding of 109Cd to MT and the thiol density of the ...
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Fuentes, Jocelyn; Arias Santé, M. Fernanda; Atala Riffo, Elías; Pastene, Edgar; Kogan Bocian, Marcelo; Speisky Cosoy, Hernán (Elsevier, 2020)The occurrence of the quercetin oxidation metabolite 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (BZF), whose antioxidant potency is notably higher than the antioxidant potency of quercetin, was investigated ...
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Gotteland, Martín; Andrews, Mónica; Toledo Cumplido, Marcela; Muñoz, Loreto; Cáceres, Paola; Anziani, Alyerina; Wittig Rovira, Emma; Speisky Cosoy, Hernán; Salazar Rodríguez, Gabriela (ELSEVIER, 2008-05)Objective: Probiotics and cranberry have been shown to inhibit Helicobacter pylori in vitro owing to bacteriocin production and high levels of proanthocyanidins, iespectively. These effects have been confirmed in clinical ...
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Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (2014)The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like β-cyclodextrin (βCD), heptakis(2,6 di-O-methyl)-β-cyclodextrin (DMβCD), and ...
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Fuentes Lemus, E.; Dorta, E.; Escobar, E.; Aspee, Alexis; Pino, E.; Abasq, M. L.; Speisky Cosoy, Hernán; Silva, E.; Lissi, E.; Davies, M. J.; López Alarcón, Camilo (Royal Society of Chemistry, 2016)The oxidation of tryptophan (Trp) residues, mediated by peroxyl radicals (ROO.), follows a complex mechanism involving free radical intermediates, and short chain reactions. The reactivity of Trp towards ROO. should be ...
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Letelier Muñoz, María Eugenia; Lepe, Ana María; Faúndez, Mario; Salazar, Julia; Marín Catalán, Rigoberto; Aracena Parks, Paula; Speisky Cosoy, Hernán (ELSEVIER SCI IRELAND, 2005-01-15)It is generally accepted that copper toxicity is a consequence of the generation of reactive oxygen species (ROS) by copper ions via Fenton or Haber-Weiss reactions. Copper ions display high affinity for thiol and amino ...
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Núñez González, Marco; Gallardo, Vivian; Muñoz, Patricia; Tapia, Victoria; Esparza, Andrés; Salazar, Julio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2004-10-01)Glutathione (GSH) constitutes the single most important antioxidant in neurons, whereas iron causes oxidative stress that leads to cell damage and death. Although GSH and iron produce opposite effects on redox cell status, ...