Browsing by Author "XX622693"

Now showing items 21-40 of 58

    • Electroporation of DNA, RNA, and morpholinos into zebrafish embryos 
      Cerda, Gustavo A.; Thomas, Jeanne E.; Allende Connelly, Miguel; Karlstrom, Rolf O.; Palma Alvarado, Verónica (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-07)
      The combination of accessible embryology and forward genetic techniques has made zebrafish a powerful model system for the study of vertebrate development. One limitation of genetic analysis is that the study of gene ...
    • Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone ... 
      Rojas, Adriana; Aguilar, Rodrigo; Henríquez, Berta; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; Wijnen, Andre J. van; Zundert, Brigitte van; Allende Connelly, Miguel; Montecino, Martín (The American Society for Biochemistry and Molecular Biology, 2015)
      Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional activation and repression ...
    • Evaluating different virulence traits of klebsiella pneumoniae using dictyostelium discoideum and zebrafish ... 
      Marcoleta, Andrés; Varas, Macarena A.; Ortiz Severin, Javiera; Vásquez, L.; Berríos Pasten, Camilo; Sabag, Andrea; Chávez Espinosa, Francisco; Allende Connelly, Miguel; Santiviago Cid, Carlos; Monasterio Opazo, Octavio; Lagos Mónaco, Rosalba (Frontiers Media SA, 2018)
      Multiresistant and invasive hypervirulent Klebsiella pneumoniae strains have become one of the most urgent bacterial pathogen threats. Recent analyses revealed a high genomic plasticity of this species, harboring a variety ...
    • Exploiting zebrafish xenografts for testing the in vivo antitumorigenic activity of microcin E492 against ... 
      Varas Poblete, Macarena; Muñoz Montecinos, Carlos; Kallens, Violeta; Simon Zegers, María Valeska; Allende Connelly, Miguel; Marcoleta Caldera, Andrés; Lagos Mónaco, Rosalba (Frontiers Media, 2020)
      One of the approaches to address cancer treatment is to develop new drugs not only to obtain compounds with less side effects, but also to have a broader set of alternatives to tackle the resistant forms of this pathology. ...
    • Expression and splice variant analysis of the zebrafish tcf4 transcription factor 
      Young, Rodrigo M.; Reyes, Ariel E.; Allende Connelly, Miguel (2002)
      Wnt signalling has been implicated in antero-posterior patterning of the vertebrate embryonic body axis and in a number of other developmental processes. One of the downstream effectors of Wnt signalling is the β-catenin ...
    • Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos 
      Bergeron, Sadie A.; Milla, Luis A.; Villegas, Rosario; Shen, Meng-Chieh; Burgess, Shawn M.; Allende Connelly, Miguel; Karlstrom, Rolf O.; Palma Alvarado, Verónica (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2007-12-11)
      The Hedgehog (Hh) signaling pathway plays critical instructional roles during embryonic development. Misregulation of Hh/Gli signaling is a major causative factor in human congenital disorders and in a variety of cancers. ...
    • Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a 
      Feijóo, Carmen Gloria; Saldías, Marioli P.; Paz, Javiera F. de la; Gómez Skarmeta, José Luis; Allende Connelly, Miguel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-12-06)
      Members of the Iroquois (Irx) homeodomain transcription factor gene family have been implicated in a variety of early developmental processes, including neural pre-patterning, tissue differentiation, neural crest development ...
    • From Devo to Evo: patterning, fusion and evolution of the zebrafish terminal vertebra 
      Cumplido Salas, Nicolás; Allende Connelly, Miguel; Arratia, Gloria (BMC, 2020)
      Background With more than 30,000 species, teleosts comprise about half of today's living vertebrates, enriched with a wide set of adaptations to all aquatic systems. Their evolution was marked by modifications of their ...
    • A functional survey of the enhancer activity of conserved non-coding sequences from vertebrate Iroquois ... 
      Calle Mustienes, Elisa de la; Feijóo, Carmen Gloria; Manzanares, Miguel; Tena, Juan J.; Rodríguez Seguel, Elisa; Letizia, Annalisa; Allende Connelly, Miguel; Gómez Skarmeta, José Luis (COLD SPRING HARBOR LAB PRESS, 2010-05-25)
      Recent studies of the genome architecture of vertebrates have uncovered two unforeseen aspects of its organization. First, large regions of the genome, called gene deserts, are devoid of protein-coding sequences and have ...
    • Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen ... 
      Parada-Kusz, Margarita; Penaranda, Cristina; Hagedorn, Elliott J.; Clatworthy, Anne; Nair, Anil V.; Henninger, Jonathan E.; Ernst, Christoph; Li, Brian; Riquelme, Raquel; Jijon, Humberto; Villablanca, Eduardo J.; Zon, Leonard I.; Hung, Deborah; Allende Connelly, Miguel (Company of Biologists Ltd, 2018)
      © 2018. Published by The Company of Biologists Ltd. Xenografts of the hematopoietic system are extremely useful as disease models and for translational research. Zebrafish xenografts have been widely used to monitor blood ...
    • Generation of Viable Plant-Vertebrate Chimeras 
      Alvarez, Marjorie; Reynaert, Nicole; Chávez, Myra N.; Aedo, Geraldine; Araya, Francisco; Hopfner, Úrsula; Fernández Hidalgo, Juan; Allende Connelly, Miguel; Egaña, José T. (Public Library Science, 2015)
      The extreme dependence on external oxygen supply observed in animals causes major clinical problems and several diseases are related to low oxygen tension in tissues. The vast majority of the animals do not produce oxygen ...
    • In vivo Host-Pathogen interaction as revealed by global proteomic profiling of zebrafish larvae 
      Díaz Pascual, Francisco; Ortiz Severin, Javiera; Varas, Macarena A.; Allende Connelly, Miguel; Chávez Espinosa, Francisco (Frontiers media SA, 2017)
      The outcome of a host-pathogen interaction is determined by the conditions of the host, the pathogen, and the environment. Although numerous proteomic studies of in vitro-grown microbial pathogens have been performed, in ...
    • The Irx gene family in zebrafish: genomic structure, evolution and initial characterization of irx5b 
      Feijóo, Carmen Gloria; Manzanares, Miguel; Calle Mustienes, Elisa de la; Gómez Skarmeta, José Luis; Allende Connelly, Miguel (SPRINGER, 2004-04-03)
      Genes of the iroquois (Iro/Irx) family are highly conserved from Drosophila to mammals and they have been implicated in a number of developmental processes. In flies, the Iro genes participate in patterning events in ...
    • Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis ... 
      Valdivia, Leonardo E.; Young, Rodrigo M.; Hawkins, Thomas A.; Stickney, Heather L.; Cavodeassi, Florencia; Schwarz, Quenten; Pullin, Lisa M.; Villegas, Rosario; Moro, Enrico; Argenton, Francesco; Allende Connelly, Miguel; Wilson, Stephen W. (2011)
      During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously generating daughters that contribute to the growing tissue. How tissues achieve this precise balance between proliferation and ...
    • La lógica de los genomas 
      Allende Connelly, Miguel (Centro de Regulación del Genoma, 2018)
      La publicación profundiza sobre uno de los grandes desafíos de la ciencia actual: la posibilidad de modificar los organismos desde su base. Desarrolla temas como la caracterización del ADN, la secuenciación genómica, las ...
    • Mechanosensory organ regeneration in zebrafish depends on a population of multipotent progenitor cells kept ... 
      Sánchez, Mario; Ceci, Maria Laura; Gutiérrez, Daniela; Anguita Salinas, Consuelo; Allende Connelly, Miguel (BioMed Central, 2016)
      Background: Regenerating damaged tissue is a complex process, requiring progenitor cells that must be stimulated to undergo proliferation, differentiation and, often, migratory behaviors and morphological changes. Multiple ...
    • Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish 
      Gallardo, Viviana E.; Liang, Jin; Behra, Martine; Elkahloun, Abdel; Villablanca, Eduardo J.; Russo, Vincenzo; Allende Connelly, Miguel; Burgess, Shawn M. (BIOMED CENTRAL, 2010-12-13)
      Background: Development of the posterior lateral line (PLL) system in zebrafish involves cell migration, proliferation and differentiation of mechanosensory cells. The PLL forms when cranial placodal cells delaminate ...
    • Novel therapies targeting cardioprotection and regeneration 
      Garrido, Valeria; Mendoza Torres, Evelyn; Riquelme, Jaime A.; Díaz, Ariel; Pizarro, Marcela; Bustamante, Mario; Chávez, Myra N.; Ocaranza, María Paz; Mellado, Rosemarie; Corbalán, Ramón; Allende Connelly, Miguel; Lavandero González, Sergio (Bentham Science Publishers, 2017)
      Cardiovascular disease is the leading cause of death worldwide. The heart is susceptible to pathologies that impact the myocardium directly, such as myocardial infarction and consequent heart failure, as well as conditions ...
    • Obituary Jose Luis Gomez-Skarmeta (1966-2020) 
      Casares, Fernando; Allende Connelly, Miguel; Felix de Celis, José; González Reyes, Acaimo; Martínez Morales, Juan Ramón (Company of Biologists, 2020)
    • Phoenix Is Required for Mechanosensory Hair Cell Regeneration in the Zebrafish Lateral Line 
      Behra, Martine; Bradsher, John; Sougrat, Rachid; Gallardo, Viviana E.; Allende Connelly, Miguel; Burgess, Shawn M. (PUBLIC LIBRARY SCIENCE, 2009-04-17)
      In humans, the absence or irreversible loss of hair cells, the sensory mechanoreceptors in the cochlea, accounts for a large majority of acquired and congenital hearing disorders. In the auditory and vestibular neuroepithelia ...