Browsing by Author "Araya Maturana, Ramiro"
Now showing items 21-39 of 39
-
Regulation of mitochondrial function as a promising target in platelet activation-related diseases Fuentes, Eduardo; Araya Maturana, Ramiro; Urra, Félix A. (Elsevier Inc., 2019)© 2019 Elsevier Inc.Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of megakaryocytes and have a unique metabolic phenotype compared with circulating leukocytes, exhibiting a high coupling ...
-
Almodovar, Iriux; Cardona, Wilson; Delgado Castro, Tomás; Zapata Torres, Gerald; Caroli Rezende, Marcos; Araya Maturana, Ramiro; Maestro, M. Carmen; García Ruano, José L. (2013)Diels-Alder cycloaddition of 8,8-dimethylnaphthalene-1,4,5(8H)-trione with diastereomeric hydroxysulfinyldienes proceeded with high yields and good π-facial and regioselectivities. The hydroxysulfoxide moiety controls the ...
-
Maestro, M. Carmen; Fernández-Salas, José Antonio; García Ruano, José L.; Ramírez-Rodríguez, Oney O.; Araya Maturana, Ramiro (2012)The ability of a homochiral sulfinyl group at the dienophile to act as a remote stereocontrol inductor in the Diels-Alder reaction with cyclopentadiene has been evaluated. High pressure conditions were required for the ...
-
Zúñiga Hormazábal, Pamela Andrea (Universidad de Chile, 2018)Los compuestos quinónicos, debido a su diversidad estructural, poseen una amplia variedad de aplicaciones. En la actualidad las más estudiadas están centradas en sus propiedades farmacológicas. En este ámbito, la posibilidad ...
-
Clavijo Allancán, Graciela Andrea (Universidad de Chile, 2013-09)Los derivados quinónicos poseen interesantes aplicaciones en áreas de la química de materiales y medicinal. Estos compuestos pueden ser encontrados tanto en la naturaleza como obtenerse sintéticamente, su síntesis ha ...
-
Muñoz Córdova, Felipe Andrés (Universidad de Chile, 2017)La mitocondria ha emergido como un promisorio blanco para eliminar selectivamente células tumorales en función de sus alteraciones bioquímicas y funcionales respecto a sus contrapartes no-tumorales, abriendo la posibilidad ...
-
Pessoa Mahana, Hernán; Kosche Cárcamo, Johann; Ron Higuera, Nadia; Recabarren Gajardo, Gonzalo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa Mahana, Carlos (2008)A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene ...
-
Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa Mahana, David; Araya Maturana, Ramiro; Ron, Nadia; Saitz Barría, Claudio (Arkat, 2009)A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b]thiophen-2- ...
-
Montecinos, R.; Ahumada, H.; Martínez, R.; Olea Carrasco, Floreal; Araya Maturana, Ramiro; Aliste, M. P.; Tieleman, D. P.; Weiss López, Boris (AMER CHEMICAL SOC, 2004-07-06)The structure and aggregation number of a discotic lyotropic liquid crystal, prepared from tetradecyltrimethylammonium chloride (TDTMACI)/decanol (DeOH)/NaCI/H2O, have been examined using fluorescence quenching of pyrene ...
-
Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)© 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
-
Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
-
Escobar, Carlos A.; Donoso Tauda, Oscar; Araya Maturana, Ramiro; Sicker, Dieter (2009)1,5-Benzodiazepines have been synthesized from the corresponding 2'-hydroxychalcones [1-(2-hydroxyphenyl)-3-aryl-2-propen-1-ones] and o-phenylenediamine, both in methanol, under reflux and under solvent-free microwave ...
-
Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Araya Maturana, Ramiro; Kosche Cárcamo, Johann Albert; Pessoa, D. (MARCEL DEKKER INC, 2004-07)We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual ...
-
Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Temer, Jenny Fiedler; Zapata Torres, Gerald; Pessoa Mahana, Carlos David; Barría, Claudio Saitz; Araya Maturana, Ramiro (2012)A series of novel benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1- one derivatives 6a-f, 7a-f and their corresponding alcohols 8a-f were synthesized and evaluated for their affinity towards 5-HT 1A receptors. The ...
-
Pessoa Mahana, Hernán; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (Bentham Science Publishers, Ltd, 2003)The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally telated to arylpiperazine, ...
-
Mejias, Lorenzo; Sepúlveda, Silvia; Araya Maturana, Ramiro; Cassels Niven, Bruce; Rezende, Marcos Caroli (Marcel Dekker Inc., 1998)Methods for the regioselective bromination of the title naphthalenone are described, which lead to isomeric hydroquinones 5 or 6.
-
Martínez Cifuentes, Maximiliano; Weiss López, Boris; Araya Maturana, Ramiro (Hindawi Limited, 2017)© 2017 Maximiliano Martínez-Cifuentes et al. The mandatory presence of a chlorine atom on the aromatic ring of 6-hydroxy-3-formyl angular chromones, on the respiration inhibition of mammary carcinoma mouse, is explained ...
-
Araya Maturana, Ramiro; Delgado Castro, Tomás; Cardona,; Weiss López, Boris (2001)The structural elucidation of complex organic molecules relies heavily on the application of proton detected heteronuclear NMR. Among these techniques, the HMBC NMR experiment is probably the most useful 2D NMR method. The ...
-
Araya Maturana, Ramiro; Pessoa Mahana, Hernán; Weiss López, Boris (2008)The structural elucidation of natural products and complex organic molecules relies heavily on the application of proton detected heteronuclear NMR. Among these techniques, the HMBC NMR experiment remains as the most popular ...