Browsing by Author "Hetz Flores, Claudio"
Now showing items 21-40 of 119
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BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
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Hetz Flores, Claudio (2010)
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Gerakis, Yannis; Hetz Flores, Claudio (Nature Publishing Group, 2019)
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Valenzuela Paterakis, Vicente Spiro (Universisdad de Chile, 2009)El daño a la médula espinal (DME) es una de las principales causas de parálisis en el adulto e involucra ruptura de axones y muerte de motoneuronas en este tejido. Los mecanismos celulares involucrados en los efectos ...
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Andreu Cafati, Catherine Iris (Universisdad de Chile, 2015)ERp57 es una proteína miembro de la familia de las proteínas Disulfuro Isomerasas y una foldasa del retículo endoplasmico que participa en el plegamiento de glicoproteinas, siendo parte del ciclo calnexina/calreticulina. ...
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Caracterización de una nueva vía de apoptosis intrínseca independiente de BAX,BAK y ciclofilina D Zamorano Villablanca, Sebastián Antonio. (Universisdad de Chile, 2009)La mayoría de los estímulos intrínsecos de muerte celular convergen en la activación de proteínas pro-apoptoticas de la familia BCL-2 en la membrana extrema de la mitocondria. Esto produce la liberación de citocromo c ...
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Díaz, María I.; Díaz, Paula; Castillo Bennett, Jimena; Urra, Hery; Ortiz, Rina; Contreras Orellana, Pamela; Hetz Flores, Claudio; Quest, Andrew F. G. (Springer Nature, 2020)Caveolin-1 (CAV1), is a broadly expressed, membrane-associated scaffolding protein that acts both, as a tumor suppressor and a promoter of metastasis, depending on the type of cancer and stage. CAV1 is downregulated in ...
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Martínez, Gabriela; Hetz Flores, Claudio (2012)
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Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview Dufey, Estefanie; Sepúlveda, Denisse; Rojas Rivera, Diego; Hetz Flores, Claudio (American Physiological Society, 2014)© 2014 the American Physiological Society. Increased demand on the protein folding capacity of the endoplasmic reticulum (ER) engages an adaptive reaction known as the unfolded protein response (UPR). The UPR regulates ...
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Converging pathways in the occurrence of endoplasmic reticulum (er) stress in Huntington's disease Vidal, R.; Caballero, B.; Couve Correa, Andrés; Hetz Flores, Claudio (2011)A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease and Parkinson's disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing ...
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Ramírez, Marcos; Gallardo, Andrés; Vidal, Aarón; Cornejo, Sebastián; Ramírez, Darío; Medinas Bilches, Danilo; Bustamante, Gonzalo; Pasquali, Renzo; Hetz Flores, Claudio (Sociedad Medica de Santiago, 2016)© 2016, Sociedad Medica de Santiago. All rights reserved. Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to ...
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Vidal, Rene L.; Hetz Flores, Claudio (Taylor and Francis Inc., 2012)Huntington disease (HD) is caused by an extended polyglutamine [poly(Q)] stretch in the Huntingtin (HTT) protein, and is associated with the accumulation of intracellular protein aggregates, onset of progressive chorea, ...
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Groenendyk, Jody; Paskevicius, Tautvydas; Urra, Hery; Viricel, Clement; Wang, Kui; Barakat, Khaled; Hetz Flores, Claudio; Kurgan, Lukasz; Agellon, Luis B.; Michalak, Marek (Nature Publishing Group, 2018)© 2018, The Author(s). Cyclosporine, a widely used immunosuppressant in organ transplantation and in treatment of various autoimmune diseases, activates the unfolded protein response (UPR), an ER stress coping response. ...
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Steele, Andrew D.; King, Oliver D.; Jackson, Walker S.; Hetz Flores, Claudio; Borkowski, Andrew W.; Thielen, Peter; Wollmann, Robert; Lindquist, Susan (2007)B-cell lymphoma protein 2 (Bcl-2) and Bcl-2-associated X protein (Bax), key antiapoptotic and proapoptotic proteins, respectively, have important roles in acute and chronic models of neurologic disease. Several studies ...
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Bargsted, Leslie; Medinas Bilches, Danilo; Martínez Traub, Francisca; Rozas, Pablo; Muñoz, Natalia; Nassif, Melissa; Jerez, Carolina; Catenaccio, Alejandra; Court, Felipe A.; Hetz Flores, Claudio; Matus, Soledad (Nature Publishing Group, 2017)Tar DNA binding protein 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tissue of most cases of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ...
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Lhomond, Stephanie; Avril, Tony; Dejeans, Nicolas; Hetz Flores, Claudio (Wiley, 2018)Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
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Castillo Salgado, Valentina Fernanda (Universidad de Chile, 2016)
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Rozas Rojas, Pablo Sebastián (Universidad de Chile, 2017)
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Limia, Celia Maria; Sauzay, Chloé; Urra, Hery; Hetz Flores, Claudio; Chevet, Eric; Avril, Tony (MDPI AG, 2019)Endoplasmic reticulum (ER) proteostasis is often altered in tumor cells due to intrinsic (oncogene expression, aneuploidy) and extrinsic (environmental) challenges. ER stress triggers the activation of an adaptive response ...
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Díaz-Hung, Mei-Li; Martínez Bravo, Gabriela; Hetz Flores, Claudio (Elsevier, 2020)Stressors elicit a neuroendocrine response leading to increased levels of glucocorticoids, allowing the organism to adapt to environmental changes and maintain homeostasis. Glucocorticoids have a broad effect in the body, ...