Now showing items 21-40 of 137

    • Jullian Matthaei, Carolina; Orosteguis, Teresita; Pérez Cruz, Fernanda; Sánchez, Paulina; Mendizábal Emaldía, Fernando; Olea Azar, Claudio (2008)
      Properties of inclusion complexes between morin (M) and β-cyclodextrin (βCD), 2-hydroxypropyl-β-cyclodextrin (HPβCD) and Heptakis (2,6-O-di methyl) β-cyclodextrin (DMβCD) such as aqueous solubility and the association ...
    • Jullian Matthaei, Carolina; Moyano, L.; Yáñez Soto, Claudia; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2007-05)
      The slightly water-soluble flavonoid quercetin (QUE) and its inclusion with either beta-cyclodextrin (beta CD), hydroxypropyl-beta-cyclodextrin (HP-beta CD) or sulfobutyl ether-beta-cyclodextrin (SBE-beta CD) were investigated. ...
    • Mendizábal Emaldía, Fernando; Reyes, Dana; Olea Azar, Claudio (JOHN WILEY, 2006-03-15)
      Hydrogen bonding and metallophilic attractions are studied in the model systems: [(AuNH3Cl)(2)], [(AuNH(CH3)(2)Cl)(2)], [{Au-2(mu-SH)(PH2O)(PH2OH}(2)], [(CuNH3Cl)(2)], and [{Cu(NH3)Cl}(4)] at the Hartree-Fock (HF) and ...
    • Mera Adasme, Raúl; Mendizábal Emaldía, Fernando; González, Mauricio; Miranda Rojas, Sebastián; Olea Azar, Claudio; Sundholm, Dage (2012)
      Impairment of the Zn(II)-binding site of the copper, zinc superoxide dismutase (CuZnSOD) protein is involved in a number of hypotheses and explanations for the still unknown toxic gain of function mutant varieties of CuZnSOD ...
    • Paulino, M.; Iribarne, F.; Hansz, M.; Vega, M.; Seoane, G.; Cerecetto, Hugo; Di Maio, R.; Caracelli, I.; Zukerman-Schpector, J.; Olea Azar, Claudio; Stoppani, A. O. M.; Berriman, M.; Fairlamb, A. H.; Tapia, O. (ELSEVIER SCIENCE BV, 2002-04-26)
      A computer assisted molecular modeling was used to design molecules having a shape complementary to the active site of glutathione reductase (GR) and trypanothione reductase (TR). The designed 5-nitro compound derivatives. ...
    • Olea Azar, Claudio; Parra Mouchet, Julia (Elsevier, 1997)
      Conformational analysis of famotidine (FAMO) and some analogues have been performed using AM1 calculations. In addition, conformational analysis were done on the 2-guanidinylthiazole moiety in order to see the effect of ...
    • Zúñiga, María A.; Pérez Roa, Rodolfo E.; Olea Azar, Claudio; Laurie, V. Felipe; Agosin Trumper, Eduardo (Elsevier, 2014)
      In this research, we determined the chemical composition of 37 Vitis vinifera cv. Carme´ne` re wines and established their antioxidant capacity (AC). A set of 26 measurements of chemical species potentially related to ...
    • Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (2008)
      Cu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing ...
    • Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-07-01)
      Cu2+ ions and GSH molecules interact to swiftly form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing Cu(I)– ...
    • Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Navarrete-Encina, Patricio; Squella Serrano, Juan (Elsevier, 1997)
      The present paper reports on the electrochemical characterization by cyclic voltammetry of two 1,4-benzodiazepines, loprazolam and flunitrazepam in protic, aprotic and mixed media. In protic media (ethanol + 15 mM citrate ...
    • Jullian Matthaei, Carolina; Brossard, Victor; González, Iván; Alfaro, Muriel; Olea Azar, Claudio (SPRINGER/PLENUM PUBLISHERS, 2011-04)
      The slightly water-soluble flavonoid kaempferol (KAE) and its inclusion complexes with beta-cyclodextrin (beta CD), hydroxypropyl-beta-cyclodextrin (HP beta CD) or heptakis-2,6-O-dimethyl-beta-cyclodextrin (DM beta CD) ...
    • Toro, Patricia; Suazo, Constanza; Acuña, Alejandra; Fuentealba, Mauricio; Artigas, Vania; Arancibia, Rodrigo; Olea Azar, Claudio; Moncada, Mauricio; Wilkinson, Shane; Klahn, A. Hugo (Elsevier, 2018)
      A novel series of cyrhetrenyl (3a-4a) and ferrocenyl (3b-4b) Schiff bases were synthesized through a condensation reaction, between the known 4-ferrocenylaniline (2b) or the unreported 4-cyhretrenylaniline (2a) with 4-or ...
    • Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)
      Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
    • Espinoza, M.; Olea Azar, Claudio; Massif, G.; Villa Litovosky, Alberto (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-12)
      Reference materials are essential tools to achieve comparability and traceability between measurements. However, reference materials in food matrices are scarce. in this article, the development of a reference material for ...
    • Núñez Vergara, Luis; Pardo Jiménez, V; Barrientos, C.; Olea Azar, Claudio; Navarrete-Encina, P. A.; Squella Serrano, Juan (2012)
      In this study, two series of dihydropyridine-fused and pyridine-fused coumarins were synthesised and electrochemically characterised in aprotic medium. In both series, the most easily reducible groups were the endocyclic ...
    • González Fuentes, Pamela A.; Zúniga López, María C.; Olea Azar, Claudio; Loyola, Cristina; Folch Cano, Christian G. (Pontificia Universidad Católica de Chile, 2017)
      The production of high quality natural Antioxidants from olive pruning wood extracts and their application to prevent the oxidation of vegetable oils were evaluated. The production of antioxidants from branches of olive ...
    • Costa, Erivaldo de Oliveira; Molina, María Teresa; De Abreu, Fabiane C.; dos Santos Silva, Francisco de Assis; Costa, Cicero de Oliveira; Pinho, Waldomiro; Valentim, Iara B.; Aguilera Venegas, Benjamín; Pérez Cruz, Fernanda; Norambuena, Ester; Olea Azar, Claudio (2012)
      The present work aims to investigate the electrochemical behavior of nine naphthoquinones, in aprotic and protic media. The reduction mechanism of the quinones in aprotic medium was proposed, with involvement of anion ...
    • Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)
      A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
    • Barriga González, Germán; Olivares Petit, Carla; Toro, Patricia M.; Klahn, A. Hugo; Olea Azar, Claudio; Maya Arango, Juan D.; Huentupil, Yosselin; Arancibia, Rodrigo (Soc. Chilena de Química, 2020)
      The bioorganometallic compounds 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) and 2-ferrocenyl-5-nitro-benzimidazole (Bzn-2) have been proposed as potential anti-Trypanosoma cruzi agents. In this regard, electrochemical, ...