Browsing by Author "Squella Serrano, Juan"
Now showing items 21-40 of 231
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Finger Caraccioli, Sebastián (Universidad de Chile, 2007)En el presente estudio se investigó mediante técnicas electroquímicas tres derivados 4-(m-nitrosofenil)-1,4-dihidropiridina (m-NO-DHP) en medio acuoso. Las m-NO-DHP estudiadas: 2,6-dimetil-3,5-dimetoxicarbonil-4-(meta ...
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López Menadier, Marcelo Leonardo (Universidad de Chile, 2006)En esta Memoria se estudió la reactividad de tres nuevas 1,4-dihidropiridinas (1,4-DHP) frente al anión radical superóxido (O2 .-), y se evaluó la influencia de los sustituyentes en posición 4 del anillo dihidropiridí ...
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Morales Montecinos, Juan Pablo (Universidad de ChilePrograma Cybertesis, 2007)En la presente memoria se reporta la caracterización electroquímica y la reactividad con radicales libres, alquilo y alquilperoxilo ABAP-derivados de tres nuevas 1,4 dihidropiridinas C4-substituidas (3,4,5-trihidroxifenil-DHP, ...
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Salgado Figueroa, Paola; Gutiérrez, C.; Squella Serrano, Juan (Elsevier, 2015)tA simple and sensitive electrochemical method using pretreated carbon nanofiber screen printed elec-trodes joined to a flow injection analysis (CNF-SPE-FIA) system was developed to analyze nimodipine(NMD) in pharmaceutical ...
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Squella Serrano, Juan; Núñez Vergara, Luis (1984)The isolation and identification of a cathodic degradation product from cephradine after acidic hydrolysis in presence of 1 % formaldehyde is reported. Also, the electroacti vity of an anodic degradation product is described. ...
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Squella Serrano, Juan; Pezzani, M.; Cassels Niven, Bruce; Aillón Torres, Milton; Rezende, Marcos; Núñez Vergara, Luis (1992)The amphetamine derivative 4,5‐dimethoxy‐2‐nitrophenyl‐2‐aminopropane, a positional isomer of the potent hallucinogen DON, was studied by cyclic voltammetry and polarography. The nitro compound was reduced to the corresponding ...
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Núñez Vergara, Luis; Squella Serrano, Juan; Navarrete Encina, Patricio; Vicente-García, E.; Preciado, S.; Lavilla, R. (2011)Chromenopyridines constitute a structurally diverse class of compounds with a wide range of bioactivities and increasing presence in drugs. Here we analyze the scope of the synthetic methodology to access this nucleus with ...
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Inostroza Ramírez, Elizabeth Guillermina (Universidad de Chile, 2016)Los electrodos modificados con nanotubos de carbono han recibido considerable interés debido a sus amplias propiedades estructurales, mecánicas, químicas y electrónicas. Entre estas propiedades se destacan la alta estabilidad ...
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Cyclic voltammetric and EPR spectroscopic studies of benzodiazepines: Loprazolam and flunitrazepam Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Navarrete-Encina, Patricio; Squella Serrano, Juan (Elsevier, 1997)The present paper reports on the electrochemical characterization by cyclic voltammetry of two 1,4-benzodiazepines, loprazolam and flunitrazepam in protic, aprotic and mixed media. In protic media (ethanol + 15 mM citrate ...
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Bollo Dragnic, Soledad; Yáñez Soto, Claudia; Sturm Schaub, Juan; Núñez Vergara, Luis; Squella Serrano, Juan (AMER CHEMICAL SOC, 2003-04-15)Potassium ferricyanide ([Fe(CN)(6)](3-)) reduction and ferrocenemethanol (Fe-OH) oxidation at a beta-cyclodextrin (beta-CD)-modified gold electrode were investigated by cyclic voltammetry (CV) and scanning electrochemical ...
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Bollo Dragnic, Soledad; Yáñez, Claudia; Sturm, Juan; Núñez Vergara, Luis; Squella Serrano, Juan (2003)Potassium ferricyanide (Fe(CN)6]3-) reduction and ferrocenemethanol (Fc-OH) oxidation at a β-cyclodextrin (β-CD)-modified gold electrode were investigated by cyclic voltammetry (CV) and scanning electrochemical microscopy ...
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Ortíz Yáñez, María Eugenia; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE, 2002-02-08)We have studied the O-2/O-2(.-) redox couple on the HMDE in DMSO aprotic media, obtaining optimal conditions of both oxygen concentration and scan rate in order to avoid oscillatory phenomena. By choosing the oxygen ...
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Ortiz,; Núñez Vergara, Luis; Squella Serrano, Juan (2002)We have studied the O2/O2·- redox couple on the HMDE in DMSO aprotic media, obtaining optimal conditions of both oxygen concentration and scan rate in order to avoid oscillatory phenomena. By choosing the oxygen concentration ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE, 2004-01-15)PA-824 (2-nitro-6-(4-trifluoromethoxy-benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine) is being tested as antituberculosis drug. Little is known on the action mechanism of PA-824; however the reduction of the nitro ...
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Bollo Dragnic, Soledad; Núñez Vergara, Luis; Bontá, M.; Chauviere, G.; Perie, J.; Squella Serrano, Juan (ELSEVIER SCIENCE, 2001-09-21)Megazol (2-amino-5-(1-methyl-5-nitro-2-imdazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) and related nitroimidazole compounds are being tested as antichagasic drugs. Little is known on the mode of action of megazol. However, ...
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Carbajo, J.; Bollo Dragnic, Soledad; Núñez Vergara, Luis; Campero, A.; Squella Serrano, Juan (ELSEVIER SCIENCE, 2002-08-23)We have chosen 4-nitroimidazole (4-NIm) as a prototype of nitroimidazolic compounds in order to carry out an exhaustive cyclic voltammetric study in protic media, 0.1 M Britton-Robinson buffer+0.3 M KCl with ethanol as a ...
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Cyclic voltammetric study of the nitro radical anion from nitrendipine generated electrochemically Squella Serrano, Juan; Mosre, J.; Blázquez, M.; Núñez Vergara, Luis (1991)Electrochemical studies on nitrendipine using mixed aqueous/dimethylformamide (DMF) solvent have allowed us to generate the one-electron reduction product, the nitro radical anion, RNO.-2. The voltammetric technique has ...
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Cyclic voltammetry and digital simulation of the electroreducction of ortho-and meta-nitro aryl ... Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan (Sociedad Chilena de Química, 1999)Cyclic voltammetry (CV) and digital simulation methods are utilezed to elucidate the mechanism of electrochemical reduction of a series of nitro aryl 1,4-dihydropyridines im protic (aqueous) and mixed media. The experimental ...
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Cyclic voltammetry and digital simulation of the electroreduction of ortho- and meta-nitro aryl ... Bollo Dragnic, Soledad; Núñez Vergara, Luis; Squella Serrano, Juan (1999)Cyclic voltammetry (CV) and digital simulation methods are utilized to elucidate the mechanism of electrochemical reduction of a series of nitro aryl 1,4-dihydropyridines in protic (aqueous) and mixed media. The experimental ...
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Bollo Dragnic, Soledad; Finger Caraccioli, Sebastián; Sturm Schaub, Juan; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER, 2007-04-20)The heterogeneous electron transfer reaction for the reduction of some nitroso aromatic derivatives in aqueous-alcoholic medium was studied on both mercury and glassy carbon electrodes (GCE) by using cyclic voltammetry ...