Now showing items 1-19 of 19

    • Acuña Castillo, Claudio; Scorza, Cecilia; Reyes Parada, Miguel; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Elsevier Science Inc., 2000-06-06)
      To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either of the rat cRNA for the ...
    • Campo, Andrea del; Salamanca, Catalina; Fajardo, Ángelo; Díaz Castro, Francisco; Bustos, Catalina; Calfío, Camila; Troncoso Cotal, Rodrigo Hernán; Pastene Navarrete, Edgar Rafael; Acuña Castillo, Claudio; Milla, Luis A.; Villarroel, Carlos A.; Cubillos, Francisco A.; Aranda, Mario; Rojo, Leonel E. (MDPI, 2021)
      Type 2 diabetes and obesity are major problems worldwide and dietary polyphenols have shown efficacy to ameliorate signs of these diseases. Anthocyanins from berries display potent antioxidants and protect against weight ...
    • Li, Min; Torres, Claudio; Acuña Castillo, Claudio; Walter, Robin Ann; Gardner, Elizabeth M.; Murasko, Donna M.; Sierra, Felipe (2002)
      We have previously reported on a defect in both extracellular signal-regulated protein kinase (ERK) and c-jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) activation in splenocytes obtained from old rats. ...
    • Acuña Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R.; Sáez, Patricio; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Nature Publishing Group, 2002-04-04)
      1 The pharmacological pro®le of a series of (+)-2,5-dimethoxy-4-(X)-phenylisopropylamines (X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes injected with cRNA coding ...
    • Gómez, Christian; Acuña Castillo, Claudio; Pérez Núñez, Claudio; Leiva Salcedo, Elías; Riquelme, Denise; Ordenes, Gamaliel; Oshima, Kiyoko; Aravena, Mauricio; Pérez, Viviana I.; Nishimura, Sumiyo; Sabaj Diez, Valeria; Walter, Robin Ann; Sierra, Felipe (GERONTOLOGICAL SOC AMER, 2008-12)
      Aging is associated with a deterioration of the acute phase response to inflammatory challenges. However, the nature of these defects remains poorly defined. We analyzed the hepatic inflammatory response after intraperitoneal ...
    • Robles Planells, Claudia (Universidad de Chile, 2018-09)
      El melanoma maligno es un tipo de cáncer a la piel de baja incidencia, pero elevada tasa de mortalidad, por ello continúa la búsqueda de terapias complementarias para su tratamiento. La viroterapia antitumoral aprovecha ...
    • Barrera Ávalos, Carlos Esteban; Díaz, Ximena; Madrid, Sebastián; Michelson, Sofía A.; Robles Planells, Claudia Julieta; Sánchez Guerrero, Giselle; Ahumada, Viviana; Mella Torres, Andrea Jesús; Rojo, Leonel E.; Imarai Bahamonde, Mónica; Milla, Luis A.; Leiva Salcedo, Elías; Murgas, Paola; Fernández, Ricardo; Escobar, Alejandro; Acuña Castillo, Claudio (Hindawi, 2021)
      Active immunotherapy against cancer is based on immune system stimulation, triggering efficient and long-lasting antigen-specific immune responses. Immunization strategies using whole dead cells from tumor tissue, containing ...
    • Leiva Salcedo, Elías; Coddou, Claudio; Rodríguez, Felipe; Penna, Antonello; López, Ximena; Neira, Tanya; Fernández, Ricardo; Imarai, Mónica; Rios, Miguel; Escobar, Jorge; Montoya, Margarita; Huidobro Toro, Juan; Escobar, Alejandro; Acuña Castillo, Claudio (2011)
      The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
    • Escobar Álvarez, Alejandro; Candia, Enzo; Reyes Cerpa, Sebastián; Villegas Valdés, Bélgica; Neira, Tanya; López Nitsche, Mercedes; Maisey, Kevin; Tempio, Fabián; Ríos, Miguel; Acuña Castillo, Claudio; Imarai, Mónica (Hindawi, 2013)
      Neisseria gonorrhoeae is the etiological agent of gonorrhoea, which is a sexually transmitted disease widespread throughout the world. N. gonorrhoeae does not improve immune response in patients with reinfection, suggesting ...
    • Ortiz, María Carolina; Lefimil Puente, Claudia; Rodas, Paula I.; Vernal Astudillo, Rolando; López, Mercedes; Acuña Castillo, Claudio; Imarai, Mónica; Escobar, Alejandro (Public Library Science, 2015)
      Current data suggest that Neisseria gonorrhoeae is able to suppress the protective immune response at different levels, such as B and T lymphocytes and antigen-presenting cells. The present report is focused on gonococcus ...
    • Barrera Ávalos, Carlos; Briceño, Pedro; Valdés, Daniel; Imarai, Mónica; Leiva Salcedo, Elías; Rojo, Leonel E.; Milla, Luis A.; Huidobro Toro, Juan Pablo; Robles Planells, Claudia; Escobar Álvarez, Alejandro; Di Virgilio, Francesco; Morón, Gabriel; Sauma Mahaluf, Daniela Macarena; Acuña Castillo, Claudio (Cell, 2021)
      T cell activation requires the processing and presentation of antigenic peptides in the context of a major histocompatibility complex (MHC complex). Cross -dressing is a non-conventional antigen presentation mechanism, ...
    • Miranda, Dante; Jara, Claudia; Ibañez, Jorge; Ahumada, Viviana; Acuña Castillo, Claudio; Martin, Adrian; Córdova, Alexandra; Montoya, Margarita (Hindawi Publishing Corporation, 2016)
      Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. ...
    • Cappelli, Claudio; López Cortés, Ximena; Labra, Yohana; Montoya, Margarita; Fernández, Ricardo; Imarai, Mónica; Rojas, Juan Luis; Miranda, Dante; Escobar Alvarez, Alejandro; Acuña Castillo, Claudio (Elsevier, 2012)
      Regulatory T cells (Treg) are important in the development of immune tolerance under normal physiological conditions. However, in pathological situations such as cancer, Treg increases have been correlated with bad ...
    • Gómez, Christian; Acuña Castillo, Claudio; Nishimura, Sumiyo; Pérez, Viviana; Escobar, Alejandro; Salazar Onfray, Flavio; Sabaj Diez, Valeria; Torres, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      There is considerable controversy about the molecular mechanisms responsible for the variations in innate immunity associated with age. While in vivo, aged animals and humans react to an inflammatory signal with ail excessive ...
    • Aravena, Mauricio; Pérez, C.; Pérez, V.; Acuña Castillo, Claudio; Gómez, Christian; Leiva Salcedo, Elías; Nishimura, Sumiyo; Sabaj, B.; Walter, Robin Ann (ELSEVIER SCI IRELAND LTD, 2005-03)
      T-kininogen (T-KG) is a precursor of T-kinin, the most abundant kinin in rat serum, and also acts as a strong and specific cysteine proteinase inhibitor. Its expression is strongly induced during aging in rats, and expression ...
    • Pérez, Viviana; Leiva Salcedo, Elías; Acuña Castillo, Claudio; Aravena, Mauricio; Gómez, Christian; Sabaj Diez, Valeria; Colombo, Alicia; Nishimura, Sumiyo; Pérez Núñez, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      Basal proliferation of endothelial cells increases with age, and this might play a role in the etiology of age-related vascular diseases, as well as angiogenesis. Serum kininogen levels increase during aging in rats and ...
    • Leiva-Salcedo, Elias; Perez, Viviana; Acuña Castillo, Claudio; Walter, Robin Ann; Sierra, Felipe (Society of Biology of Chile, 2002)
      Serum levels of T-kininogen increase dramatically as rats approach the end of their lifespan. Stable expression of the protein in Balb/c 3T3 fibroblasts leads to a dramatic inhibition of cell proliferation, as well as ...
    • Acuña Castillo, Claudio; Aravena, Mauricio; Leiva Salcedo, Elías; Pérez, Viviana; Gómez, Christian; Sabaj Diez, Valeria; Nishimura, Sumiyo; Pérez Núñez, Claudio; Colombo, Alicia; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2005-12)
      Plasma levels of kininogens increase with age in both rats and humans. Kininogens are inhibitors of cysteine proteinases, and filarial cysteine proteinase inhibitors (cystatins) reduce the proliferation of T cells. We ...
    • Acuña Castillo, Claudio; Leiva-Salcedo, Elias; Gómez, Christian R.; Pérez, Viviana; Li, Min; Torres, Claudio; Walter, Robin Ann; Murasko, Donna M.; Sierra, Felipe (Gerontological Society of America, 2006)
      T-kininogen (T-KG) is a reliable biomarker of aging in male Sprague-Dawley rats. Here we confirm, in a longitudinal study, a similar behavior in Fisher 344 rats of both sexes. In males, the increase in serum levels of T-KG ...