Now showing items 1-20 of 20

    • Araya, Magdalena; Núñez, Héctor; Pavez, Leonardo; Arredondo Olguín, Miguel Armando; Méndez, Marco; Cisternas, Felipe; Pizarro Aguirre, Fernando; Sierralta, Walter; Uauy Dagach-Imbarack, Ricardo; González Canales, Mauricio (American Society for Nutrition, 2012)
      Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that ...
    • Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Rojas, Alejandro; Arredondo Olguín, Miguel Armando; Núñez González, Marco (2006)
      Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. ...
    • Arredondo Olguín, Miguel Armando; Tapia, Victoria; Rojas, Alejandro; Aguirre, Pabla; Reyes, Francisca; Marzolo Canales, María Paz; Núñez González, Marco (SPRINGER, 2005-10-03)
      Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
    • Leiva, Elba; Mujica, Verónica; Orrego, Roxana; Prieto, María; Arredondo Olguín, Miguel Armando (ELSEVIER IRELAND, 2005-06)
      Apolipoprotein E (apo E) modulates the metabolism of atherogenic lipoprotein particles and participates in the process of cellular incorporation of specific lipoproteins. Genetic polymorphism of apo E: has beets reported ...
    • Suazo Romo, Miriam; Olivares, Felipe; Méndez, Marco; Pulgar Tejo, Rodrigo; Prohaska, Joseph R.; Arredondo Olguín, Miguel Armando; Pizarro Aguirre, Fernando; Ordóñez Pizarro, Fernando; Araya, Magdalena; González Canales, Mauricio (ELSEVIER SCIENCE INC, 2008-04)
      The limits of copper homeostatic regulation in humans are not known, making it difficult to define the milder effects of early copper excess. Furthermore, a robust assay to facilitate the detection of early stages of ...
    • Araya, Magdalena; Andrews, Mónica; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando (Springer, 2012-04)
      Assessment of proteins in blood and other tissues has failed to identify markers of early copper effects on health. Studies in animal models show that chaperone of SOD (CCS) respond to changes of copper status. Evidence ...
    • Muñoz, Carlos; López, Marcelo; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando; Araya, Magdalena (EUROPEAN CYTOKINE NETWORK, 2005-12)
      Backgound. Copper (Cu) is an essential trace element for many biological processes including maintenance of both innate and acquired branches of immunity. Objective. To measure the effect of copper supplementation on IL-2 ...
    • Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo Olguín, Miguel Armando; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (NATL ACAD SCIENCES, 2008-11-25)
      Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson’s disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells ...
    • Pino, José Luis; Mujica, Verónica; Arredondo Olguín, Miguel Armando (Elsevier, 2021)
      There is a growing interest in the use of functional foods. Studies indicate the contribution of β-glucans to glycemic control, but few have evaluated integrally the effect of this soluble dietary fiber on appetite-regu ...
    • Fuentes, Marcela; Andrews, Mónica; Arredondo Olguín, Miguel Armando (Springer Science+Business Media, 2013)
      Type 2 diabetes is characterized by hyperglycemia and oxidative stress. Hyperglycemia is linked to mitochondrial dysfunction and reduced β-cell mass due to the reduced expression of genes such as Mfn2 as well as ...
    • Mujica, Verónica; Leiva, Elba; Icaza, Gloria; Díaz, Nora; Arredondo Olguín, Miguel Armando; Moore Carrasco, Rodrigo; Orrego, Roxana; Vásquez, Marcela; Palomo, Iván (BIOMED CENTRAL LTD, 2008-05-15)
      Objective-: Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD). Metabolic Syndrome (MS) is a clustering of metabolic alterations associated to IR; however, ...
    • Middleton Santibáñez, Maureen; Olivares Grohnert, Manuel Alonso; Espinoza, Alejandra; Arredondo Olguín, Miguel Armando; Pizarro Aguirre, Fernando Dagoberto; Valenzuela Venegas, Carolina Paz (MDPI, 2021)
      Currently, all pigs raised on intensive farms develop iron-deficiency anemia if they do not receive supplemental iron at birth. Weaning diets commonly contain high concentrations of iron, and the effect on the copper and ...
    • Andrews Guzmán, Mónica; Arredondo Olguín, Miguel Armando; Olivares Gronhert, Manuel (Aula Médica Ediciones, 2015)
      Objective: To investigate the relationship between oxidative stress and biochemical parameters and the expression of TXNIP, IL-6, IL-1 beta and TNF-alpha in peripheral mononuclear cells (PMCs) from type-2 diabetic patients. ...
    • Mendiburo, María José; Flores, Sebastián; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando (2006)
      Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe. The ...
    • Leiva, Elba; Mujica, Verónica; Brito, Katherine; Palomo, Iván; Orrego, Roxana; Moore Carrasco, Rodrigo; Vásquez, Marcela; Guzmán, Luis; Núñez, Sergio; Díaz, Nora; Icaza, Gloria; Arredondo Olguín, Miguel Armando (Wiley Periodicals, 2011)
      Aim: To determine risk parameters associated with high values of high sensitive C-reactive protein (hsCRP) in subjects with different glucose fasting levels. Methods: Anthropometric parameters, arterial pressure, glycemia, ...
    • Leiva, Elba; Mujica, Verónica; Sepúlveda, Pablo; Guzmán, Luis; Núñez, Sergio; Orrego, Roxana; Palomo, Iván; Andrews, Mónica; Arredondo Olguín, Miguel Armando (Springer, 2013)
      Studies concerning oxidative stress (OxE) parameters have increased, mainly because of its important role in cardiovascular diseases and diabetes complications. The main objective of this study was to evaluate iron ...
    • Urrutia, Pamela J.; Aguirre, Pabla; Esparza, Andrés; Tapia, Victoria; Mena, Natalia P.; Arredondo Olguín, Miguel Armando; González Billault, Christian; Núñez González, Marco (2013)
      Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer’s disease and Parkinson’s disease. The study of the putative association between inflammation and iron ...
    • Arredondo Olguín, Miguel Armando; Martínez, Ronny; Núñez González, Marco; Ruz, Manuel; Olivares Grohnert, Manuel (2006)
      Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical ...
    • Mazariegos, Dora Inés; Pizarro Aguirre, Fernando; Ordóñez Pizarro, Fernando; Núñez González, Marco; Arredondo Olguín, Miguel Armando (AMER INST NUTRITION, 2004-02)
      Inorganic iron (Fe) absorption from the diet is controlled mainly in the intestinal tract where apical Fe uptake is inversely related to the Fe content in the enterocyte. Iron bis-glycine chelate is an iron compound that ...
    • Arredondo Olguín, Miguel Armando; Salvat, Valentina; Pizarro Aguirre, Fernando; Olivares Grohnert, Manuel (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05)
      Bioavailability results, obtained in humans, of wheat flour fortified with elemental iron might not be reliable because these studies have been performed using tracer iron compounds that probably do not have the same ...