Browsing by Author "Behrens Pellegrino, María Isabel"

Now showing items 1-20 of 23

    • Age-dependent increases in apoptosis/necrosis ratios in human lymphocytes exposed to oxidative stress 
      Behrens Pellegrino, María Isabel; Silva, Monica; Schmied, Astrid; Salech Morales, Felipe; Manzur, Hachi; Rebolledo, Rolando; Bull Simpfendorfer, Ricardo; Torres, Vicente; Henríquez, Mauricio; Quest, Andrew F. G. (2011)
      Unlike apoptosis, mechanisms leading to necrosis are less well understood. Moreover, changes in necrosis as a function of age have not been studied in human lymphocytes. H 2O 2-induced death of peripheral lymphocytes (56 ...
    • Association of Parkinson disease to PARK16 in a Chilean sample 
      Ramírez, Alfredo; Ziegler, Andreas; Winkler, Susen; Kottwitz, Jan; Giesen, Roland; Díaz Grez, Fernando; Miranda, Marcelo; Venegas Francke, Pablo; Trujillo Godoy, Osvaldo; Avello, Rodrigo; Behrens Pellegrino, María Isabel; Klein, Christine; Segura Aguilar, Juan; Lohmann, Katja (Elsevier, 2011-01)
    • ATP13A2 variants in early-onset Parkinson's disease patients and controls 
      Djarmati, Ana; Hagenah, Johann; Reetz, Kathrin; Winkler, Susen; Behrens Pellegrino, María Isabel; Pawlack, Heike; Lohmann, Katja; Ramirez, Alfredo; Tadić, Vera; Brüggemann, Norbert; Berg, Daniela; Siebner, Hartwig R.; Lang, Anthony E.; Pramstaller, Peter P.; Binkofski, Ferdinand; (John Wiley and Sons Inc., 2009)
      Four genes responsible for recessively inherited forms of Parkinson's disease (PD) have been identified, including the recently discovered ATP13A2 (PARK9) gene. Our objective was to investigate the role of this gene in a ...
    • Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers: Ion conduction and gating ... 
      Behrens Pellegrino, María Isabel; Oberhauser, Andres; Bezanilla, Francisco; Latorre, Ramón (1989)
      Squid optic nerve sodium channels were characterized in planar bilayers in the presence of batrachotoxin (BTX). The channel exhibits a conductance of 20 pS in symmetrical 200 mM NaCI and behaves as a sodium electrode. The ...
    • Cancer imprints an increased PARP-1 and p53-Dependent resistance to oxidative stress on lymphocytes of ... 
      Salech Morales, Felipe; Ponce, Daniela P.; San Martín Rovirosa, Carol; Rogers Castillo, Nicole; Henríquez, Mauricio; Behrens Pellegrino, María Isabel (Frontiers Media, 2018)
      We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that ...
    • Cancer linked to Alzheimer disease but not vascular dementia 
      Roe, Catherine M.; Fitzpatrick, A. L.; Xiong, C.; Sieh, W.; Kuller, L.; Miller, J. P.; Williams, M. M.; Kopan, R.; Behrens Pellegrino, María Isabel; Morris, J. C. (2010-01-12)
      Objective: To investigate whether cancer is associated with Alzheimer disease (AD) and vascular dementia (VaD). Methods: Cox proportional hazards models were used to test associations between prevalent dementia and risk ...
    • Caracterización morfológica de la microglía y los astrocitos en respuesta al patógeno oral Aggregatibacter ... 
      Muñoz Bermúdez, Ignacio Leopoldo (Universidad de Chile, 2022)
      La periodontitis corresponde a una patología caracterizada por una inflamación mediada por el huésped asociada a microbios, que resulta en pérdida de inserción periodontal. Las bacterias asociadas en este proceso podrían ...
    • Cien años de la enfermedad de Alzheimer. La inmunoterapia ¿una esperanza? 
      Behrens Pellegrino, María Isabel; Vergara E., Fernando (2007)
      In 1906 Alois Alzheimer, described the cerebral lesions characteristic of the disorder that received his name: senile plaques and neurofibrillary tangles. Alzheimer’s disease (AD) is now, 100 years after, the most prevalent ...
    • Clinical Spectrum of Kufor-Rakeb Syndrome in the Chilean Kindred with ATP13A2 Mutations 
      Behrens Pellegrino, María Isabel; Brüggemann, Norbert; Chana, Pedro; Venegas Francke, Pablo; Kägi, Marianne; Parrao, Teresa; Orellana, Patricia; Garrido, Cristián; Rojas, Cecilia V.; Hauke, Jan; Hahnen, Eric; González Victoriano, Rafael; Seleme Herrero, Eduardo; Fernández, Verónica; Schmidt, Alexander; Binkofski, Ferdinand; Kömpf, Detlef; Kubisch, Christian; Hagenah, Johann; Klein, Christine; Ramírez, Alfredo (2010)
      Abstract: We report the clinical features of the original Chilean family with Kufor-Rakeb syndrome (KRS) that led to the discovery of the ATP13A2 gene at the PARK9 locus. KRS is a rare juvenile-onset autosomal recessive ...
    • HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions ... 
      Mukherjee, Odity; Pastor, Pau; Cairns, Nigel J.; Chakraverty, Sumi; Kauwe, John S. K.; Shears, Shantia; Behrens Pellegrino, María Isabel; Budde, John; Hinrichs, Anthony L.; Norton, Joanne; Levitch, Denise; Taylor-Reinwald, Lisa; Gitcho, Michael; Tu, P.-H.; Grinberg, Lea Tenenholz; Liscic, Rajka M.; Armendariz, Javier; Morris, John C.; Goate, Alison M. (WILEY-LISS, DIV JOHN WILEY & SONS, 2006-09)
      Objective: Familial autosomal dominant frontotemporal dementia with ubiquitin-positive, tau-negative inclusions in the brain linked to 17q21-22 recently has been reported to carry null mutations in the progranulin gene ...
    • Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase 
      Ramírez, Alfredo; Heimbach, André; Gründemann, Jan; Stiller, Barbara; Hampshire, Dan; Cid, L. Pablo; Goebel, Ingrid; Mubaidin, Ammar F.; Wriekat, Abdul-Latif; Roeper, Jochen; Al-Din, Amir; Hillmer, Axel M.; Karsak, Meliha; Liss, Birgit; Woods, C. Geoffrey; Behrens Pellegrino, María Isabel; Kubisch, Christian (NATURE PUBLISHING GROUP, 2006-10)
      Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders(1). Although the complex molecular pathophysiology ...
    • Inverse Association between Cancer and Dementia of the Alzheimer’s Type 
      Behrens Pellegrino, María Isabel; Roe, Catherine M.; Morris, John C. (Nova Science Publishers, Inc., 2008)
      With increasing life expectancy there is also a concomitant increase in the prevalence of agerelated disorders, including neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various cancers. ...
    • Inverse susceptibility to oxidative death of lymphocytes obtained from Alzheimer's patients and skin cancer ... 
      Behrens Pellegrino, María Isabel; Silva, Monica; Salech Morales, Felipe; Ponce, Daniela P.; Merino, Daniela; Sinning, Mariana; Xiong, Chengjie; Roe, Catherine M.; Quest, Andrew F. G. (2012)
      A paucity of cancer in individuals with Alzheimer's disease (AD) and low rates of AD in cancer survivors has been reported in epidemiological studies. Deregulation in opposite directions of biological mechanisms, such as ...
    • Memoria, fluidez y orientación: prueba de cribado de deterioro cognitivo en 5 minutos 
      Delgado Derio, C.; Guerrero Bonnet, S.; Troncoso Ponce, M.; Araneda Yáñez, A.; Slachevsky Chonchol, Andrea; Behrens Pellegrino, María Isabel (Elsevier, 2013)
      Antecedentes: En los próximos 20 a˜nos se duplicará la cantidad de personas con deteriorocognitivo (DC) apremiando su pronta detección.Objetivos: Validar una prueba de cribado de DC aplicable en < de 5 min.Métodos: Adultos ...
    • Mild cognitive impairment: Follow-up of ten patients Deterioro cognitivo leve: Seguimiento de 10 casos 
      Donoso, Archibaldo; Behrens Pellegrino, María Isabel; Venegas, Pablo (2003)
      36 patients who presented with mild cognitive impairment (MCI) (memory loss and a Minimental test de Folstein (MMT) of 25-30) had previously been followed up for 31 months: 15 developed Alzheimer dementia, 11 got better ...
    • Neural control of the expression of a Ca2+-activated K+ channel involved in the induction of myotonic-like ... 
      Ramírez, Beatriz U.; Behrens Pellegrino, María Isabel; Vergara Montecinos, Cecilia (Kluwer Academic/Plenum Publishers, 1996)
      1. Expression of the apamin-sensitive K+ channel (SK+) in rat skeletal muscle is neurally regulated. The regulatory effect of the nerve over the expression of some muscle ion channels has been attributed to the electrical ...
    • Neuropathologic Heterogeneity in HDDD1: A Familial Frontotemporal Lobar Degeneration With Ubiquitin-positive ... 
      Behrens Pellegrino, María Isabel; Mukherjee, Odity; Tu, Pang-hsien; Liscic, Rajka M.; Grinberg, Lea Tenenholz; Carter, Deborah; Paulsmeyer, Katherine; Taylor-Reinwald, Lisa; Gitcho, Michael; Norton, Joanne; Chakraverty, Sumi; Goate, Alison M.; Morris, John C.; Cairns, Nigel J. (Lippincott Williams & Wilkins, 2007-03)
      Hereditary dysphasic disinhibition dementia (HDDD) describes a familial disorder characterized by personality changes, and language and memory deficits. The neuropathology includes frontotemporal lobar atrophy, neuronal ...
    • Olfactory deficits and cognitive dysfunction in Parkinson's disease 
      Parrao, Teresa; Chana, Pedro; Venegas, Pablo; Behrens Pellegrino, María Isabel; Aylwin, María Luz (2012)
      Background: Olfactory deficits and executive dysfunction have been reported in Parkinson's disease (PD). However, the association between these deficits has not been thoroughly examined. Methods: We studied 44 PD subjects ...
    • Rendimiento cognitivo en pacientes chilenos con cardiopatía coronaria y factores de riesgo cardiovascular 
      Delgado Derio, C.; Vásquez Vivar, Carolina; Orellana Pineda, Ana; Reccius Meza, A.; Donoso Sepúlveda, Archibaldo; Behrens Pellegrino, María Isabel (2008)
      Introducción. La presencia de factores de riesgo cardiovascular (FRCV) se relaciona con una peor evolución cognitiva a largo plazo. La cardiopatía coronaria (CC) se ha asociado inconstantemente a mala evolución cognitiva. ...
    • Senescence markers in peripheral blood mononuclear cells in amnestic mild cognitive impairment and alzheimer’s ... 
      Salech Morales, Felipe Humberto; San Martín Rovirosa, Carol Dazil; Concha Cerda, Jorge Ignacio; Romero Hernández, Esteban Ignacio; Ponce, Daniela P.; Liabeuf Altamirano, Gianella Alejandra; Rogers Castillo, Nicole Andrea; Murgas, Paola; Bruna, Bárbara; More, Jamileth; Behrens Pellegrino, María Isabel (MDPI, 2022)
      Recent studies suggest that cellular senescence plays a role in Alzheimer’s Disease (AD) pathogenesis. We hypothesize that cellular senescence markers might be tracked in the peripheral tissues of AD patients. Senescence ...