Now showing items 1-20 of 39

    • Neira Villegas, Jocelyn Cecilia (Universidad de ChileCyberDocs, 2008)
      La migración de los linfocitos a los órganos linfoides secundarios es un paso crucial en la iniciación de la respuesta inmune adquirida. Este fenómeno es caracterizado por múltiples eventos que requieren de interacciones ...
    • Morales Peña, José; Bono Merino, María Rosa; Fierro, A.; Iñiguez, R.; Zehnder, C.; Rosemblatt Silber, Mario César; Calabran, L.; Herzog, C.; Benavente, D.; Aguiló, J.; Pefaur, J.; Alba, A.; Ferrario, M.; Simon, W.; Contreras, L.; Buckel González, Erwin (ELSEVIER SCIENCE INC, 2008-11)
      Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection ...
    • Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Frontiers Media, 2015)
      The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction ...
    • Moore, Carolina; Tejón, Gabriela; Fuentes, Camila; Hidalgo, Yessia; Bono Merino, María Rosa; Maldonado, Paula; Fernández, Ricardo; Wood, Kathryn; Fierro, Juan; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bushell, Andrew (Wiley-Blackwell, 2015)
      CD4+CD25+Foxp3+ regulatory T (Treg) cells mediate immunological self-tolerance and suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has been reported to enhance the differentiation of ...
    • Díaz Amor, Patricia Virginia Rosa; Gaggero Brillouet, Aldo; Pinto Muñoz, Ricardo; Mamani, Rossana; Uasapud, Paola A.; Bono Merino, María Rosa (2013)
      Background: An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection. Aim: To quantify pro-inflammatory cytokines (IL-6-IL-8, IL-1-β and TNF-α) in nasopharyngeal ...
    • González Silva, Carolina; Vera, Jorge; Bono Merino, María Rosa; González Billault, Christian; Baxter, Brooke; Hansen, Anne; López, Robert; Gibson, Emily A.; Restrepo, Diego; Bacigalupo Vicuña, Juan (PLoS ONE, 2013)
      The Ca2+-activated Cl2 channel is considered a key constituent of odor transduction. Odorant binding to a specific receptor in the cilia of olfactory sensory neurons (OSNs) triggers a cAMP cascade that mediates the opening ...
    • Valdivieso Berríos, Nicolás Alejandro (Universidad de Chile, 2019-08)
      El Lupus Eritematoso Sistémico (LES) es una enfermedad autoinmune caracterizada por la hiperactividad de células T y B autorreactivas, la producción de autoanticuerpos y la formación de complejos inmunes que terminan ...
    • Bono Merino, María Rosa; Fernández, Dominique; Flores Santibáñez, Felipe; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Elsevietr, 2015)
      Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
    • Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Farías, Paula; Vargas, Leonardo; Simon Zegers, María Valeska; Cárdenas, César; Lladser, Álvaro; Salazar Onfray, Flavio Andrés; Elorza, Álvaro A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
    • Flores Santibáñez, Felipe; Fernández, Dominique; Meza, Daniel; Tejón, Gabriela; Vargas, Leonardo; Varela Nallar, Lorena; Arredondo, Sebastián; Guixé Leguía, Victoria Cristina; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Wiley & Sons, 2015)
      The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
    • Pino, Karina; Michea, Paula; Sauma Mahaluf, Daniela; Alba, Andrea; Morales, Jorge; Bono Merino, María Rosa; Fierro, Alberto; Rosemblatt Silber, Mario César (SOC BIOLGIA CHILE, 2010-08-12)
      One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
    • Sauma Mahaluf, Daniela; Fierro, Alberto; Mora, J.R.; Lennon Duménil, Ana María; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Morales Peña, José (ELSEVIER, 2003-11)
      The mode of action of cyclosporine (CsA) has been ascribed to its capacity to inhibit IL-2 and IFNgamma production by T cells, two cytokines implicated in allograft rejection. Recently, it has been reported that upon ...
    • Gleisner, Maria Alejandra; Reyes, Paz; Alfaro, Jennifer; Solanes, Paola; Simon, Valeska; Crisostomo, Natalia; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2013)
      Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increase in the percentage of autoreactive B and T lymphocytes. Since dendritic cells (DCs) are essential for B cell and T cell function, ...
    • Moore, C.; Sauma Mahaluf, Daniela; Reyes Pérez, P. A.; Morales Peña, José; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Fierro, J. A. (ELSEVIER, 2010)
      Background. CD4 CD25 Foxp3 regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression ...
    • Jørgensen, Trine N.; Alfaro, Jennifer; Enríquez, Hilda L.; Jiang, Chao; Loo, William M.; Atencio, Stephanie; Bupp, Melanie R. Gubbels; Mailloux, Christina M.; Metzger, Troy; Flannery, Shannon; Rozzo, Stephen J.; Kotzin, Brian L.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Erickson, Loren D. (The American Association of Immunologists, Inc., 2010)
      Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss ofimmune ...
    • Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Tucer, Suat; Saavedra Almarza, Juan Pablo; Hormann Cornejo, Pilar Leonor; Martínez, Brandon A.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Cekic, Caglar; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      Ecto-5 '-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is ...
    • Michea, Paula; Vargas, Pablo; Donnadieu, Marie-Hélène; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Duménil, Guillaume; Soumelis, Vassili (WILEY-VCH Verlag GmbH & Co., 2013)
      Plasmacytoid pre-dendritic cells (pDCs) are specialized in responding to nucleic acids, and link innate with adaptive immunity. Although the response of pDCs to viruses is well established, whether pDCs can respond to ...
    • Navarrete Sánchez, Mariela Ivonne (Universidad de Chile, 2018-03)
      Las Gap Junctions (GJs) son clústers de canales intercelulares localizados en la membrana plasmática que permiten la comunicación directa entre células adyacentes. Cada canal GJ está compuesto por 2 hemicanales hexaméricos ...
    • Salas Cortés, Laura; Jaubert, Francis; Bono Merino, María Rosa; Fellous, Marc; Rosemblatt Silber, Mario César (2001)
      Sex determination in mammals is controlled by the SRY gene located on the Y chromosome. It encodes a protein containing a DNA-binding and DNA-bending domain. In spite of recent advances in the identification of the mechanisms ...
    • Elgueta, Raúl; Tobar, Jaime A.; Shoji, Kenji F.; De Calisto, Jaime; Kalergis, Alexis M.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Sáez, Juan C. (AMER ASSOC IMMUNOLOGISTS, 2009-04-30)
      The acquired immune response begins with Ag presentation by dendritic cells (DCs) to naive T cells in a heterocellular cell-cell contact-dependent process. Although both DCs and T cells are known to express connexin43, a ...