Now showing items 1-20 of 26

    • Gálvez, A. S.; Ulloa Valenzuela, Juan Alberto; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Eisner, Verónica; Barros, L.; Lavandero González, Sergio (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
      Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
    • Eisner, Verónica; Quiroga Lagos, Clara; Criollo Céspedes, Alfredo; Olea Azar, Claudio; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 2004)
      Meeting Abstract
    • Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Parra Ortíz, María Valentina; Eisner, Verónica; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Moraga, Francisco; García, Alejandra; Haertel, Steffen; Jaimovich Pérez, Enrique; Zorzano, Antonio; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2008-01-15)
      Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
    • Alfaro, Iván E.; Albornoz, Amelina; Molina, Alfredo; Moreno, José; Cordero, Karina; Criollo Céspedes, Alfredo; Budini, Mauricio (Frontiers Media, 2019)
      Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. While ...
    • Criollo Céspedes, Alfredo; Galluzzi, Lorenzo; Chiara Maiuri, M.; Tasdemir, Ezgi; Lavandero González, Sergio; Kroemer, Guido (2013)
    • Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2006-06-12)
      NF kappa B is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NF kappa B pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase ...
    • Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibáñez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (ELSEVIER, 2006-08-07)
      We have recently shown that hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFKB is regulated in cultured ...
    • Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Helene; Maiuri, M. C.; Morselli, E.; Vitale, I.; Kepp, O.; Tasdemir, E.; Galluzzi, Lorenzo; Shen, S.; Tailler, M.; Delahaye, N.; Tesniere, A.; De Stefano, D.; Ben Younes, Amena; Harper, F.; Pierron, G.; Lavandero González, Sergio; Zitvogel, L.; Israel, A; Baud, V; Kroemer, Guido (NATURE PUBLISHING GROUP, 2010-02-03)
      In response to stress, cells start transcriptional and transcription-independent programs that can lead to adaptation or death. Here, we show that multiple inducers of autophagy, including nutrient depletion, trigger the ...
    • Vicencio, José Miguel; Ortíz, C.; Criollo Céspedes, Alfredo; Jones, A. W. E.; Kepp, O.; Galluzzi, Lorenzo; Joza, N.; Vitale, I.; Morselli, E.; Tailler, M.; Castedo, M.; Maiuri, M. C.; Molgó, Jordi; Szabadkai, G.; Lavandero González, Sergio; Kroemer, Guido (NATURE PUBLISHING GROUP, 2009-07)
      The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
    • Criollo Céspedes, Alfredo; Vicencio, José Miguel; Tasdemir, E.; Maiuri, M. C.; Lavandero González, Sergio; Kroemer, Guido (LANDES BIOSCIENCE, 2007-07)
      The second messenger myo-inositol-1,4,5-trisphosphate (IP3) acts on the IP3 receptor (IP3R), an IP3-activated Ca2+ channel of the endoplasmic reticulum (ER). The IP3R agonist IP3 inhibits starvation-induced autophagy. The ...
    • Maldonado, Carola; Eisner, Verónica; Gálvez, Anita; Ulloa Valenzuela, Juan Alberto; Criollo Céspedes, Alfredo; Ocaranza Osses, Paula; Eltit Ortega, José Miguel; Morales, María Paz; Quiroga Lagos, Clara; Campos Bastidas, Ximena; Chiong Lay, Mario; Sapag Hagar, Mario; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      La apoptosis junto a la paraptosis y la necrosis constituyen las principales formas de muerte celular conocidas hasta la fecha. La apoptosis se caracteriza por una disminución del volumen celular y formación de "cuerpos ...
    • Criollo Céspedes, Alfredo; Galluzzi, Lorenzo; Maiuri, M. C.; Tasdemir, E.; Lavandero González, Sergio; Kroemer, Guido (SPRINGER, 2007-01)
      HeLa and HCT116 cells respond differentially to sorbitol, an osmolyte able to induce hypertonic stress. In these models, sorbitol promoted the phenotypic manifestations of early apoptosis followed by complete loss of ...
    • Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Espinosa Lemunao, Rodrigo; Gutiérrez, Karla; Ríos Castillo, Javiera; Ormeño, Fernando; Yantén, Liliana; Galaz Davison, Pablo; Ramírez Sarmiento, César; Parra Ortiz, Valentina; Albornoz, Amelina; Alfaro, Iván E.; Burgos, Patricia; Morselli, Eugenia; Criollo Céspedes, Alfredo; Budini, Mauricio (MDPI, 2022)
      The intake of food with high levels of saturated fatty acids (SatFAs) is associated with the development of obesity and insulin resistance. SatFAs, such as palmitic (PA) and stearic (SA) acids, have been shown to accumulate ...
    • Chiong Lay, Mario; Parra, V.; Eisner, V.; Ibarra, C.; Maldonado, C.; Criollo Céspedes, Alfredo; Bravo, R.; Quiroga, C.; Contreras, A.; Vicencio Bustamante, José; Cea, P.; Bucarey, J.; Molgó, Jordi; Jaimovich Pérez, Enrique; Hidalgo Tapia, María Cecilia; Kroemer, G.; Lavandero González, Sergio (2010)
      Hyperosmotic stress promotes rapid and pronounced apoptosis in cultured cardiomyocytes. Here, we investigated if Ca2+ signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] ...
    • Pedrozo Cibils, Zully; Criollo Céspedes, Alfredo; Battiprolu, Pavan K.; Morales, Cyndi R.; Contreras Ferrat, Ariel Eduardo; Fernández, Carolina; Jiang, Nan; Luo, Xiang; Caplan, Michael J.; Somlo, Stefan; Rothermel, Beverly A.; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Lippicott Williams & Wilkins, 2015)
      Background-L-type calcium channel activity is critical to afterload-induced hypertrophic growth of the heart. However, the mechanisms governing mechanical stress-induced activation of L-type calcium channel activity are ...
    • Criollo Céspedes, Alfredo (Universidad de ChileCyberDocs, 2009)
      La macroautofagia, comúnmente referida como “autofagia” es la principal vía de degradación de proteínas, organelos y material citoplasmático, permitiendo de este modo el reciclaje del material intracelular. Este proceso ...
    • Criollo Céspedes, Alfredo; Maiuri, M. C.; Tasdemir, E.; Vitale, I.; Fiebig, A. A.; Andrews, D.; Molgó, Jordi; Díaz, J.; Lavandero González, Sergio; Harper, F.; Pierron, G.; di Stefano, D.; Rizzuto, R.; Szabadkai, G.; Kroemer, Guido (NATURE PUBLISHING GROUP, 2007-05)
      The reduction of intracellular 1,4,5-inositol trisphosphate (IP3) levels stimulates autophagy, whereas the enhancement of IP3 levels inhibits autophagy induced by nutrient depletion. Here, we show that knockdown of the ...
    • Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...