Browsing by Author "González, Carlos"

Now showing items 1-18 of 18

    • Anion permeation in human CIC-4 channels 
      Hebeisen, Simon; Heidtmann, Hannelore; Cosmelli, Diego; González, Carlos; Poser, Barbara; Latorre, Ramón; Álvarez Araya, Osvaldo; Fahlke, Christoph (BIOPHYSICAL SOCIETY, 2003-04)
      CIC-4 and CIC-5 are mammalian CIC isoforms with unique ion conduction and gating properties. Macroscopic current recordings in heterologous expression systems revealed very small currents at negative potentials, whereas a ...
    • Apoptosis en tumor venéreo transmisible del canino en fase de crecimiento progresivo y durante regresión ... 
      González, Carlos; Cepeda, Raquel; Flores Pavez, Estefanía; Cattaneo Univaso, Gino; Reyes, Susana (Universidad de Chile, 2003)
      Apoptosis or programmed cell death is a mechanism of cell elimination when they are unnecessary or genetically damaged. It is controlled by a variety of genes, many of which present mutation or dysfunstion associated to ...
    • Ca2+-activated K+ channel inhibition by reactive oxygen species 
      Soto, Marco A.; González, Carlos; Lissi Gervaso, Eduardo A.; Vergara Montecinos, Cecilia; Latorre, Ramón (AMER PHYSIOLOGICAL SOC, 2002-03)
      We studied the effect of H2O2 on the gating behavior of large-conductance Ca2+-sensitive voltage-dependent K+ (K-V,K-Ca) channels. We recorded potassium currents from single skeletal muscle channels incorporated into ...
    • Counting channels: a tutorial guide on ion channel fluctuation analysis 
      Álvarez Araya, Osvaldo; González, Carlos; Latorre, Ramón (American Physiological Society, 2002)
      Ion channels open and close in a stochastic fashion, following the laws of probability. However, distinct from tossing a coin or a die, the probability of finding the channel closed or open is not a fixed number but can ...
    • Detección y atribuciones de los síntomas de estados mentales de alto riesgo (EMAR) por familiares de primer grado 
      Labra Farías, Mariel (Universidad de Chile, 2023)
      La esquizofrenia es una enfermedad neuropsiquiátrica severa que afecta al 0.7% de la población mundial. Sin embargo, la gravedad y cronicidad de esta enfermedad hacen que la prevención y la detección temprana sean un ...
    • Effects of iconic gestures on the working memory of students with mild intellectual disability Efectos de ... 
      Muñoz Quezada, María Teresa; Lucero, Boris; González, Carlos (2010)
      The paper reviews how gestures influence the working memory of students with mild intellectual disability. Our general hypothesis is that retention of verbal information in working memory will vary as a function of the use ...
    • Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients 
      Candia, Enzo; Díaz Jiménez, David; Langjahr, Patricia; Núñez, Lucía E.; Fuente, Marjorie de la; Farfán, Nancy; López Kostner, Francisco; Abedrapo Moreira, Mario Antonio; Alvarez Lobos, Manuel; Pinedo, George; Beltrán, Caroll J.; González, Carlos; González Burgos, María Julieta; Quera Pino, Rodrigo (2012)
      Toll-like receptor 2 (TLR2) is a type I pattern recognition receptor that has been shown to participate in intestinal homeostasis. Its increased expression in the lamina propria has been associated with the pathogenesis ...
    • Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced arthritis 
      González, Carlos; Abello, Paula; Cepeda, Raquel; Salazar, Lorena; Aravena, Octavio; Pesce Reyes, Bárbara; Catalán Martina, Diego; Aguillón Gutiérrez, Juan Carlos (2007)
      Using the murine model of type II collagen-induced arthritis (CIA), we studied its evolution over time by histopathological, immunohistochemical and clinical evaluations. The first clinical symptoms appeared 28 days ...
    • Iwi, más barato en grupo 
      González, Carlos; Borzone, Mauro (Universidad de Chile, 2021-06)
      En la actualidad al momento de la compra, uno de los mayores problemas que presentan los chilenos de cualquier segmento, está dado por el sentimiento de abuso y desconfianza de las grandes empresas, ante el precio de ...
    • Modulation of the Shaker K+ channel gating kinetics by the S3-S4 linker 
      González, Carlos; Rosenman, Eduardo; Bezanilla, Francisco; Álvarez Araya, Osvaldo; Latorre, Ramón (ROCKEFELLER UNIV PRESS, 2000-02)
      In Shaker K+ channels depolarization displaces outwardly the positively charged residues of the S4 segment. The amount of this displacement is unknown, but large movements of the S4 segment should be con strained by the ...
    • Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1 
      Latorre, Ramón; Olcese, Riccardo; Basso, Claudia; González, Carlos; Muñoz, Fabián; Cosmelli, Diego; Álvarez Araya, Osvaldo (ROCKEFELLER UNIV PRESS, 2003-10)
      Animal and plant voltage-gated ion channels share a common architecture. They are made up of four subunits and the positive charges on helical S4 segments of the protein in animal K+ channels are the main voltage-sensing ...
    • Ovine placenta at high altitudes: Comparison of animals with different times of adaptation to hypoxic environment 
      Parraguez Gamboa, Víctor; Atlagich, Miljenko; Díaz, Rodrigo; Cepeda, Raquel; González, Carlos; Reyes Solovera, Mónica de los; Bruzzone Valdés, María Eugenia; Behn Thiele, Claus; Raggi Saini, Luis (ELSEVIER, 2006-09)
      Fetal growth and newborn weight from ovine gestations at high altitudes (HA) are greater in ewes that live at HA for several generations than in those native to low altitudes (LA) exposed to HA only during pregnancy. Because ...
    • Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker 
      González, Carlos; Rosenman, Eduardo; Bezanilla, Francisco; Álvarez Araya, Osvaldo; Latorre, Ramón (NATL ACAD SCIENCES, 2001-08-14)
      Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu, This charge movement leads to channel opening. In ...
    • Temperature and Voltage Coupling to TRPM8 Channel Opening 
      Castillo, Juan; González, Carlos; Álvarez Araya, Osvaldo; Latorre, Ramón (Cell Press, 2015)
    • Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its ... 
      Cavieres, Viviana A.; González, Alexis; Muñoz, Vanessa C.; Yefi, Claudia P.; Bustamante, Hianara A.; Barraza, Rafael R.; Tapia Rojas, Cheril; Otth, Carola; Barrera, María José; González, Carlos; Mardones, Gonzalo A.; Inestrosa, Nibaldo C.; Burgos, Patricia V. (Public Library Science, 2015)
      Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta (A beta) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation ...
    • The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels 
      García, Isaac E.; Villanelo, Felipe; Contreras, Gustavo F.; Pupo, Amaury; Pinto, Bernardo I.; Contreras, Jorge E.; Pérez Acle, Tomás; Alvarez, Osvaldo; Latorre, Ramón; Martínez, Agustín D.; González, Carlos (Rockefeller University Press, 2018)
      Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Ribeiro, Carolina Hager; López, Nandy C.; Ramírez, Galia A.; Valck, Carolina E.; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm (2009)
      Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Hager Ribeiro, Carolina; López Bartolucci, Carolina; Ramírez Toloza, Galia; Valck Calderón, Carolina Eliana; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm; Ferreira, Arturo (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03)
      Trypanosoma cruzi (T cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There is ...