Browsing by Author "Israel Jacard, Yedy"

Now showing items 1-12 of 12

    • A dual treatment blocks alcohol binge-drinking relapse: microbiota as a new player 
      Ezquer, Fernando; Quintanilla González, María Elena; Morales Retamales, Eugenia; Santapaul, Daniela; Munita, José Manuel; Moya Flores, Francisco; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy (Elsevier, 2022)
      Rationale: Gut microbiota communicates information to the brain. Some animals are born with a gut microbiota that predisposes to high alcohol consumption, and transplantation of fecal material from alcoholics to mice ...
    • A novel morphine drinking model of opioid dependence in rats 
      Berrios Cárcamo, Pablo; Quezada, Mauricio; Santapau, Daniela; Morales Retamales, Eugenia; Olivares, Belén; Ponce, Carolina; Ávila, Alba; Gregorio, Cristian de; Ezquer, Marcelo; Quintanilla González, María Elena; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy; Ezquer, Fernando (MDPI, 2022)
      An animal model of voluntary oral morphine consumption would allow for a pre-clinical evaluation of new treatments aimed at reducing opioid intake in humans. However, the main limitation of oral morphine consumption in ...
    • Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats 
      Quintanilla González, María Elena; Tampier de Jong, Lutske; Valle-Prieto, Araceli; Sapag, Amalia; Israel Jacard, Yedy (FEDERATION AMER SOC EXP BIOL, 2005-06)
      Animals selectively bred for a desirable trait retain wanted genes but exclude genes that may counteract the expression of the former. The possible interactions between selected and excluded genes cannot be readily studied ...
    • Effects of Ethanol on Hepatic Blood Flow in the Rat 
      Iturriaga, Hernán; Bunout Barnett, Daniel; Petermann, Margarita; Ugarte, Guillermo; Israel Jacard, Yedy (1981)
      Hepatic blood flow measured by indocyanine green clearance was studied in rats after an acute intoxicating dose of ethanol (2 g/kg) or after chronic ethanol administration by feeding with alcohol liquid diets. Acute ...
    • Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an ... 
      Garver, E.; Tu, G. C.; Cao, Q. N.; Aini, M.; Zhou, F.; Israel Jacard, Yedy (Rockefeller University Press, 2001)
      A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde ...
    • Gene and antisense delivery in alcoholism research 
      Israel Jacard, Yedy; Crews, F. T.; Thurman, R. G.; Tu, G. C.; Garver, E.; Ponnappa, B.; Karahanian, E.; Rubin, R.; Hoplight, B.; Sethna, M.; Hanes, R.; Wilkie, M. B.; Wheeler, M. D. (Lippincott Williams and Wilkins, 2002)
      This article represents the proceedings of a symposium at the 2001 annual meeting of the Research Society on Alcoholism in Montreal, Canada. Drs. Yedy Israel and Fulton Crews were organizers and co-chairpersons. The ...
    • Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational ... 
      Israel Jacard, Yedy; Quintanilla González, María Elena; Ezquer, Fernando; Morales, Paola; Rivera Meza, Mario; Karahanian, Eduardo; Ezquer, Marcelo; Herrera Marschitz, Mario (Nature Publishing Group, 2019)
      Studies reviewed show that lentiviral gene therapy directed either at inhibiting the synthesis of brain acetaldehyde generated from ethanol or at degrading brain acetaldehyde fully prevent ethanol intake by rats bred for ...
    • Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol ... 
      Ezquer, Fernando; Morales Retamales, Paola; Quintanilla González, María Elena; Santapau, Daniela; Lespay Rebolledo, Carolyne; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Nature, 2018)
      Chronic alcohol intake leads to neuroinflammation and astrocyte dysfunction, proposed to perpetuate alcohol consumption and to promote conditioned relapse-like binge drinking. In the present study, human mesenchymal stem ...
    • Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding ... 
      Karahanian, Eduardo; Rivera Meza, Mario; Tampier de Jong, Lutske; Quintanilla González, María Elena; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Society for the Study of Addiction, 2014)
      Previous studies suggest that acetaldehyde generated from ethanol in the brain is reinforcing. The present studies tested the feasibility of achieving a long-term reduction of chronic and post-deprivation binge ethanol ...
    • Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde ... 
      Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Israel Jacard, Yedy (Lippincott Williams & Wilkins, 2005)
      Dependence on alcohol, a most widely used drug, has a heritability of 50-60%. Wistar-derived rats selectively bred as low-alcohol consumers for many generations present an allele (Aldh22) of mitochondrial aldehyde ...
    • Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems ... 
      Quintanilla González, María Elena; Tampier de Jong, Lutske; Sapag, Amalia; Gerdtzen Hakim, Ziomara; Israel Jacard, Yedy (AMER PHYSIOLOGICAL SOC, 2007-08)
      Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. Individuals who carry the most active alcohol dehydrogenase (ADH) isoforms are protected against ...
    • The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake 
      Quintanilla González, María Elena; Israel Jacard, Yedy; Sapag, Amalia; Tampier de Jong, Lutske (BLACKWELL, 2006-09)
      Ethanol non-drinker (UChA) and drinker (UChB) rat lines derived from an original Wistar colony have been selectively bred at the University of Chile for over 70 generations. Two main differences between these lines are ...