Browsing by Author "Kalergis, Alexis M."
Now showing items 1-15 of 15
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(American Association of Immunologists, 2010)Excessive production of aldosterone leads to the development of hypertension and cardiovascular disease by generating an inflammatory state that can be promoted by T cell immunity. Because nature and intensity of T cell ...
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(Sociedad de Biología de Chile, 2021)Background: Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ efector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate innate ...
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(2010)Introduction: Several molecules help preserve peripheral B cell tolerance, but when altered, they may predispose to autoimmunity. This work studied the expression of the costimulatory molecule CD86 and the inhibitory ...
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(BLACKWELL, 2008-08)Infection with Salmonella enterica serovar Typhimurium (S. Typhimurium) causes a severe and lethal systemic disease in mice, characterized by poor activation of the adaptive immune response against Salmonella-derived ...
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(Frontiers Media, 2021)Neutrophils are immune cells classically defined as pro-inflammatory effector cells. However, current accumulated evidence indicates that neutrophils have more versatile immune-modulating properties. During acute lung ...
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(Endocrine Society, 2015)Na+/I- symporter (NIS) mediates iodide (I-) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated ...
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(AMER ASSOC IMMUNOLOGISTS, 2009-04-30)The acquired immune response begins with Ag presentation by dendritic cells (DCs) to naive T cells in a heterocellular cell-cell contact-dependent process. Although both DCs and T cells are known to express connexin43, a ...
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(Elsevier, 2012)Although the study of thermoregulation in insects has shown that infected animals tend to prefer higher temperatures than healthy individuals, the immune response and energetic consequences of this preference remain ...
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(Springer, 2023)Adequate iodine nutrition is fundamental for all humans and is critical during pregnancy and lactation due to iodine forms part of the structure of thyroid hormones (THs) and it is required for THs function. Iodine is a ...
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(MDPI, 2022)An important virulence trait of Salmonella enterica serovar Typhimurium (S. Typhimurium) is the ability to avoid the host immune response, generating systemic and persistent infections. Host cells play a crucial role in ...
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Maternal Hypothyroxinemia impairs Spatial Learning and Synaptic nature and function in the Offspring (Endocrine Society, 2008-10)Neurological deficits in the offspring caused by human maternal hypothyroxinemia are thought to be irreversible. To understand the mechanism responsible for these neurological alterations, we induced maternal hypothyroxinemia ...
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(MDPI, 2021)Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin ...
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(Wiley, 2020)Background: Increased Rho-kinase activity in circulating leucocytes is observed in heart failure with reduced ejection fraction (HFrEF). However, there is little information in HFrEF regarding other Rho-kinase pathway ...
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Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases (Elsevier, 2015)Dendritic cells (DCs) play a key role in the activation of the immune response against pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags). Furthermore, an imbalance in the activating/inhibitory ...
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(2007)Dendritic cells (DCs) are professional, antigen-presenting cells, which induce and regulate T cell reactivity. DCs are crucial in innate and adaptive immune responses, and are also involved in central and peripheral tolerance ...
