Browsing by Author "Lapier, Michel"

Now showing items 1-12 of 12

    • Benznidazole prevents endothelial damage in an experimental model of Chagas disease 
      Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Leiva, Mario; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Elsevier, 2013)
      Objectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice ...
    • Endogenous overexpression of an active phosphorylated form of DNA polymerase beta under oxidative stress ... 
      Rojas, Diego A.; Urbina, Fabiola; Moreira Ramos, Sandra; Castillo, Christian; Kemmerling Weis, Ulrike; Lapier, Michel; Maya Arango, Juan; Solari Illescas, Aldo; Maldonado Maldonado, Edio (Public Library Science, 2018)
      Trypanosoma cruzi is exposed during its life to exogenous and endogenous oxidative stress, leading to damage of several macromolecules such as DNA. There are many DNA repair pathways in the nucleus and mitochondria ...
    • ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted ... 
      Aguilera, Benjamín; Olea Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal Emaldía, Fernando; Lapier, Michel; Maya Arango, Juan; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo (PERGAMON-ELSEVIER SCIENCE LTD, 2011-03)
      Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO ...
    • Estudio fisicoquímico de los complejos de inclusión de ciclodextrinas en derivados heterociclos polinitrogenados ... 
      Ramos Aguayo, Antonio Eduardo (Universidad de Chile, 2021)
      En el presente trabajo se estudiaron las propiedades fisicoquímicas de los complejos de inclusión de una nueva serie de moléculas triazólicas, conocidas como derivados de [1,2,3] triazolo [1,5 a] piridina cetona en ...
    • Evaluación química biológica de derivados bis [1,2,3] triazolo [1,5alfa] piridin cetonas, como agentes ... 
      Lapier, Michel (Universidad de Chile, 2015)
      La tripanosomiasis americana o enfermedad de Chagas, provocada por Trypanosoma cruzi, presenta un problema de salud pública en Latino América, abarcando cerca de 21 países. El proceso de globalización ha llevado a que la ...
    • Host–guest interaction between new nitrooxoisoaporphine and b-cyclodextrins: Synthesis, electrochemical, ... 
      Pérez Cruz, Fernanda; Aguilera Venegas, Benjamín; Lapier, Michel; Sobarzo Sánchez, Eduardo; Uriarte Villares, Eugenio; Olea Azar, Claudio (Elsevier, 2012-10-26)
      A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with b-cyclodextrin, heptakis(2,6-di ...
    • Organometallic Schiff bases derived from 5-nitrothiophene and 5-nitrofurane: Synthesis, crystallographic, ... 
      Arancibia, Rodrigo; Klahn, A. Hugo; Buono Core, Gonzalo E.; Contreras, Daniel; Barriga, Germán; Olea Azar, Claudio; Lapier, Michel; Maya Arango, Juan; Ibañez, Andrés; Garland, María Teresa (Elsevier, 2013)
      In the search for new therapeutic tools for the treatment of American trypanosomiasis, a series of novel ferrocene and cyrhetrene imine compounds, derived from 5-nitro-heterocycles, were designed, synthesized and ...
    • An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting ... 
      Urra, Félix A.; Martínez Cifuentes, Maximiliano; Pavani, Mario; Lapier, Michel; Jaña Prado, Fabián; Parra, Eduardo; Maya Arango, Juan; Pessoa Mahana, Hernán; Ferreira Parker, Jorge; Araya Maturana, Ramiro (Elsevier, 2013)
      Tumor cells present a known metabolic reprogramming, which makes them more susceptible for a selective cellular death by modifying its mitochondrial bioenergetics. Anticancer action of the antioxidant 9,10- dihydroxy-4 ...
    • Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about ... 
      Seguel, Verónica; Castro, Lorena; Reigada, Chantal; Cortés, Leonel; Díaz, María V.; Miranda, Mariana R.; Pereira, Claudio A.; Lapier, Michel; Campos Estrada, Carolina; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya, Juan D.; Lopez Muñoz, Rodrigo (Elsevier, 2016)
      Benznidazole is the first-line drug used in treating Chagas disease, which is caused by the parasite Trypanosoma cruzi (T. cruzi). However, benznidazole has limited efficacy and several adverse reactions. Pentamidine is ...
    • Protection of vascular endothelium by aspirin in a murine model of chronic Chagas’ dise 
      Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Ferreira, Jorge; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Springer, 2013)
      Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
    • Synthesis, characterization and in vitro anti-Trypanosoma cruzi and anti-Mycobacterium tuberculosis evaluations ... 
      Arancibia, Rodrigo; Klahn, A. Hugo; Lapier, Michel; Maya Arango, Juan; Ibáñez, Andrés; Garland, María Teresa; Carrère-Kremer, Séverine; Kremer, Laurent; Biot, Christophe (Elsevier, 2014)
      To study the electronic influence of the organometallic moieties in thiosemicarbazones, two short libraries of cyrhetrenyl thiosemicarbazone and ferrocenyl thiosemicarbazone hybrids were synthesized and tested for their ...
    • Water-Soluble Ruthenium Complexes Bearing Activity Against Protozoan Parasites 
      Sarniguet, Cynthia; Toloza, Jeannette; Cipriani, Micaella; Lapier, Michel; Vieites, Marisol; Toledano Magaña, Yanis; García Ramos, Juan Carlos; Ruiz Azuara, Lena; Moreno, Virtudes; Maya Arango, Juan; Olea Azar, Claudio; Gambino, Dinorah; Otero, Lucía (Springer, 2014)
      Parasitic illnesses are major causes of human disease and misery worldwide. Among them, both amebiasis and Chagas disease, caused by the protozoan parasites, Entamoeba histolytica and Trypanosoma cruzi, are responsible ...