Browsing by Author "Lavandero González, Sergio"

Now showing items 1-20 of 316

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 
      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • A new non-invasive technique for the assessment of skeletal muscle metabolism 
      Lavandero González, Sergio (2008)
    • A non-conventional solid phase for immunoradiometric assays of potential use in the diagnosis of Chagas' disease. 
      Ferreira, Arturo; Lavandero González, Sergio (1988)
    • A role for adrenaline and calmodulin in modulating cyclic AMP levels during the lactogenic cycle 
      Muñoz, Aira; Lavandero González, Sergio; Donoso, Eduardo; Puente Piccardo, Javier; Sapag Hagar, Mario (1985)
      The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. Adrenaline, a β-adrenergic receptor effector, forskolin, a direct ...
    • ACE2 and vasoactive peptides: Novel players in cardiovascular/renal remodeling and hypertension 
      Mendoza Torres, Evelyn; Oyarzún, Alejandra; Mondaca Ruff, David; Azocar, Andrés; Chiong Lay, Mario; Castro, Pablo F.; Jalil Milad, Jorge; Lavandero González, Sergio; Ocaranza, María Paz (2015)
      The renin–angiotensin system (RAS) is a key component of cardiovascular physiology and homeostasis due to its influence on the regulation of electrolyte balance, blood pressure, vascular tone and cardiovascular remodeling. ...
    • Actividad plasmática de la enzima convertidora de angiotensina I en población chilena normal y relación con ... 
      Jalil Milad, Jorge; Córdova, Samuel; Piddo Mijares, Ana María; Chamorro, Gastón; Braun J., Sandra; Vega, Jeanette; Jadue, Liliana; Lavandero González, Sergio; Jalil R., R.; Lastra, P.; Garrido, Carmen (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2000)
      El objetivo del estudio fue estimar la prevalencia de los distintos alelos del polimorfismo del gen de la enzima convertidora de angiotensina (ECA), inserción/deserción (I/D) y simultáneamente la actividad de ECA plasmática ...
    • Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome 
      Bittner, Alex; Castro Agüero, Pablo; Pérez, Osvaldo; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (OXFORD UNIV PRESS, 2006-08)
      Meeting Abstract
    • Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with ... 
      Gabrielli, Luigi; Ocaranza, María Paz; Sitges, Marta; Kanacri, Andrés; Saavedra, Rodrigo; Sepúlveda, Pablo; Sepúlveda, Luis; Rossel, Víctor; Zagolin, Mónica; Verdejo, Hugo E.; Baraona, Fernando; Zalaquett Sepúlveda, Ricardo; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Blackwell, 2017)
      Background: Right atrium function and ventricular function have significant prognos-tic value in pulmonary arterial hypertension patients. Acute changes in right ventricu-lar synchrony and right atrium function postiloprost ...
    • Agonistas de receptores serotoninérgicos activan cascadas transduccionales involucradas en la regulación ... 
      Rojas Domínguez, Paulina Soledad (Universidad de Chile, 2013)
      La Serotonina (5-HT) es un neurotransmisor detectado tempranamente durante el desarrollo del sistema nervioso central y recientemente se ha descrito su papel sobre los procesos de migración y morfología neuronal. Mediante ...
    • Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of ... 
      Gálvez, A. S.; Ulloa Valenzuela, Juan Alberto; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Eisner, Verónica; Barros, L.; Lavandero González, Sergio (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
      Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
    • Alteration in mitochondrial Ca2+ uptake disrupts insulin signaling in hypertrophic cardiomyocytes 
      Gutiérrez, Tomás; Parra, Valentina; Troncoso, Rodrigo; Pennanen, Christian; Contreras Ferrat, Ariel Eduardo; Vásquez Trincado, César Alonso; Morales, Pablo E.; López Crisosto, Camila; Sotomayor Flores, Cristian Alejandro; Chiong Lay, Mario; Rothermel, Beverly A.; Lavandero González, Sergio (BioMed Central Ltd., 2014)
      © 2014 Gutierrez et al.; licensee BioMed Central Ltd. Background: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes ...
    • An immunogenetically defined and immunodominant Trypanosoma cruzi antigen 
      Ramos Ramos,Fernanda C.; Juri,; Hoecker, G.; Lavandero González, Sergio; Pena,; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Aguillón Gutiérrez, Juan Carlos; Ferreira e Ferreira, Efigenia (1991)
      Two strains of mice, A. SW (H-2(s)) and A.CA (H-2(f)), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from ...
    • An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling 
      Ibarra, Cristián; Vicencio Bustamante, José Miguel; Varas Godoy, Manuel; Jaimovich Pérez, Enrique; Rothermel, Beverly A.; Uhlén, Per; Hill, Joseph A.; Lavandero González, Sergio (Academic Press, 2014)
      © 2014 Elsevier Ltd. In cardiomyocytes, Ca2+ plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical ...
    • Anabolic Androgenic Steroids and Intracellular Calcium Signaling: A Mini Review on Mechanisms and Physiological ... 
      Vicencio Bustamante, José Manuel; Estrada, M.; Galvis, D.; Bravo, R.; Contreras Ferrat, Ariel Eduardo; Rotter, D.; Szabadkai, G.; Hill, Joseph A.; Rothermel, B. A.; Jaimovich Pérez, Enrique; Lavandero González, Sergio (BENTHAM SCIENCE PUBL LTD, 2011-05)
      Increasing evidence suggests that nongenomic effects of testosterone and anabolic androgenic steroids (AAS) operate concertedly with genomic effects. Classically, these responses have been viewed as separate and independent ...
    • Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat ... 
      Ocaranza, María Paz; Piddo Mijares, Ana María; Faúndez Fuentes, Perla Andrea; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2002-03)
      Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ...
    • Angiotensin I-converting enzyme insertion/delection polymorphism and adrenergic response to exercise in ... 
      Jalil Milad, Jorge; Córdova, Samuel; Ocaranza, María Paz; Schumacher, Erwin; Braun J., Sandra; Chamorro, Gastón; Fardella, Carlos E.; Lavandero González, Sergio (International Medical Science for Experimental and Clinical Research, 2002)
      The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was ...
    • Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat 
      Oliveri Pérez, Carla Giovanna; Ocaranza, María Paz; Campos Bastidas, Ximena; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2001-09)
      Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ...
    • Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor 
      Díaz Araya, Guillermo; Vivar Sánchez, Raúl; Soto, C.; Copaja, Miguel; Mateluna, F.; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; Thomas, W. G.; Lavandero González, Sergio (BLACKWELL PUBLISHING, 2007-07)
      Meeting Abstract
    • Angiotensin II-regulated autophagy is required for vascular smooth muscle cell hypertrophy 
      Mondaca Ruff, David; Riquelme, Jaime A.; Quiroga, Clara; Norambuena Soto, Ignacio; Sanhueza Olivares, Fernanda; Villar-Fincheira, Paulina; Hernández-Díaz, Tomás; Cancino Arenas, Nicole; San Martin, Alejandra; García Nannig, Lorena; Lavandero González, Sergio; Chiong Lay, Mario (Frontiers Media S.A., 2019)
      Copyright © 2019 Mondaca-Ruff, Riquelme, Quiroga, Norambuena-Soto, Sanhueza-Olivares, Villar-Fincheira, Hernández-Díaz, Cancino-Arenas, San Martin, García, Lavandero and Chiong.Hypertension is a disease associated to ...
    • Angiotensin-(1-9) prevents vascular remodeling by decreasing vascular smooth muscle cell dedifferentiation ... 
      Norambuena Soto, Ignacio; Ocaranza, María Paz; Cancino Arenas, Nicole; Sanhueza Olivares, Fernanda; Villar Fincheira, Paulina; Leiva Navarrete, Sebastián; Mancilla Medina, Cristian; Moya, Jacqueline; Novoa, Ulises; Jalil, Jorge E.; Castro, Pablo F.; Lavandero González, Sergio; Chiong Lay, Mario (Pergamon-Elsevier Science, 2020)
      The renin-angiotensin system, one of the main regulators of vascular function, controls vasoconstriction, inflammation and vascular remodeling. Antagonistic actions of the counter-regulatory renin-angiotensin system, which ...