Angiotensin I-converting enzyme insertion/delection polymorphism and adrenergic response to exercise in hypertensive patients

Abstract

The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was to evaluate the influence of the ACE I/D polymorphism on the adrenergic response to isotonic exercise in middle-age hypertensive patients.