Browsing by Author "Lobos González, Lorena"

Now showing items 1-13 of 13

    • Biomimetic quantum dot-labeled B16F10 murine melanoma cells as a tool to monitor early steps of lung ... 
      Díaz García, Víctor; Guerrero, Simón; Díaz Valdivia, Natalia; Lobos González, Lorena; Kogan Bocian, Marcelo; Pérez Donoso, José; Quest, Andrew F. G. (NLM (Medline), 2018)
      Background: Numerous studies have proposed the use of fluorescent semiconductor nanoparticles or quantum dots (QDs) as novel tools to label cells and tumors. However, QD applications are limited by their toxicity in ...
    • Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models 
      Lobos González, Lorena; Aguilar Guzmán, Lorena Andrea; Fernández Ruiz, Jaime Gonzalo; Muñoz, Nicolás; Hossain, Mehnaz; Bieneck, Simone; Silva, Verónica; Burzioc, Verónica; Sviderskayae, Elena V.; Bennett, Dorothy C.; Leyton Campos, Lisette; Quest, Andrew F. G. (Lippincott Williams & Wilkins, 2014)
      Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been ...
    • Caveolin-1-containing extracellular vesicles transport adhesion proteins and promote malignancy in breast ... 
      Campos, America; Salomon, Carlos; Bustos, Rocio; Díaz, Jorge; Martínez, Samuel; Silva, Veronica; Reyes, Constanza; Díaz Valdivia, Natalia; Varas Godoy, Manuel; Lobos González, Lorena; Quest, Andrew F. G. (Future Medicine Ltd., 2018)
      © 2018 2018 Future Medicine Ltd. Breast cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths in women worldwide, whereby mortality is largely attributable to the development ...
    • Desarrollo de ribozimas de horquilla y martillo para disminuir la actividad de la deshidrogenasa aldehídica ... 
      Lobos González, Lorena (Universidad de Chile, 2007)
      Existen genes que, según las variantes que se presentan en la naturaleza,pueden ser permisivos o protectores frente al alcoholismo. El gen ALDH2 eshabitualmente permisivo (alelo ALDH2*1) porque codifica la enzimadeshidrogenasa ...
    • E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells 
      Lobos González, Lorena; Aguilar, Lorena; Díaz Jara, Jorge; Díaz, Natalia; Urra, Hery; Torres Gómez, Vicente; Silva, Verónica; Fitzpatrick, Christopher; Lladser, Álvaro; Hoek, Keith S.; Leyton Campos, Lisette; Quest, Andrew F. G. (2013)
      Theroleofcaveolin-1(CAV1)incancerishighlycontroversial.CAV1suppressesgenesthatfavortumordevelopment, yet also promotes focal adhesion turnover and migration of metastatic cells. How these contrasting observations relate ...
    • E-cadherina potencia a caveolina-1 como supresor de tumores y reduce su efecto promotor de metástasis 
      Lobos González, Lorena (Universidad de Chile, 2011)
      Caveolina-1 es una proteína de membrana esencial en la formación de caveolas, participa en el transporte de colesterol, actúa como proteína de andamiaje en señalización y ha sido descrita como un supresor de tumores. Por ...
    • Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and ... 
      Michea Acevedo, Luis; Delpiano Barriga, Ana María; Hitschfeld, C.; Lobos González, Lorena; Lavandero González, Sergio; Marusic, Elisa (ENDOCRINE SOC, 2005-03)
      There is increasing evidence for rapid nongenomic effects of aldosterone. Aldosterone has been demonstrated to alter intracellular pH and calcium in isolated cells. However, few studies have correlated these effects with ...
    • Extracellular vesicles as mediators of cancer disease and as nanosystems in theranostic applications 
      Burgos Ravanal, Renato Alberto; Campos González, América Vanessa; Díaz Vesga, Magda Carolina; González, María Fernanda; León, Daniela; Lobos González, Lorena; Leyton Campos, Lisette; Kogan, Marcelo Javier; Quest, Andrew Frederick Geoffery (MDPI, 2021)
      Simple Summary Cancer is the second leading cause of death in humans, and in 2020, 9.8 million cancer-related deaths were reported worldwide. In the last 20 years, it has become apparent that small vesicles released by ...
    • Human survivin and trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo 
      Aguilar Guzmán, Lorena Andrea; Lobos González, Lorena; Rosas, Carlos; Vallejos, Gerardo; Falcón, Cristián; Sosoniuk Roche, Eduardo Rodrigo; Coddou, Francisca; Leyton Campos, Lisette; Lemus Acuña, Luis; Quest, Andrew F. G.; Ferreira Vigouroux, Luis Arturo (2014)
      Immune-based anti-tumor or anti-angiogenic therapies hold considerable promise for the treatment of cancer. The first approach seeks to activate tumor antigen-specific T lymphocytes while, the second, delays tumor growth ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer (vol 9, 114, 2017) 
      Sandoval Bórquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Avino, Gonzalo; Bizama Soto, Carolina del Carmen; Norero, Enrique; Owen, Gareth I.; Roa Strauch, Juan Carlos; Corvalán, Alejandro H. (BMC, 2021)
    • Peptide targeted gold nanoplatform carrying miR-145 induces antitumoral effects in ovarian cancer cells 
      Salas Huenuleo, Edison Sebastián; Hernández Jorquera, Andrea Carolina; Lobos González, Lorena; Polakovicová, Iva; Morales Zavala, Francisco Andrés; Araya, Eyleen; Celis, Freddy; Romero Osses, Carmen Aurora; Kogan, Marcelo Javier (MDPI, 2022)
      One of the recent attractive therapeutic approaches for cancer treatment is restoring downregulated microRNAs. They play an essential muti-regulatory role in cellular processes such as proliferation, differentiation, ...
    • Polymorphisms in mitochondrial genes encoding complex i subunits are maternal factors of voluntary alcohol ... 
      Sapag, Amalia; González Martínez, Ginez Andrés; Lobos González, Lorena; Encina, Gonzalo; Tampier de Jong, Lutske; Israel Jacard, Yedy; Quintanilla González, María Elena (2009)
      OBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD) such that, in the rat, the availability of NAD contributes to control voluntary ethanol intake. The ...
    • The Caveolin-1 connection to cell death and survival 
      Quest, Andrew F. G.; Lobos González, Lorena; Nuñez, S.; Sanhueza, C.; Fernández, J. G.; Aguirre, A.; Rodríguez, D.; Leyton, L.; Torres, V. (2013)
      Caveolins are a family of membrane proteins required for the formation of small plasma membrane invaginations called caveolae that are implicated in cellular trafficking processes. In addition to this structural role, these ...