Browsing by Author "Marcelain Cubillos, Katherine"

Now showing items 1-20 of 23

    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 
      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Caracterización clínica, citogenética y molecular de un nuevo caso de síndrome de Nijmegen en Chile 
      Marcelain Cubillos, Katherine; Aracena A., Mariana; Be R., Cecilia; Navarrete Suárez, Carmen; Moreno H., Rosa; Santos A., Manuel; Pincheira Vega, Juana (SOC MEDICA SANTIAGO, 2004-02)
      The Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive disorder associated with microcephaly, immunodeficiency, chromosome instability and cancer proneness. The mutated gene that results in NBS codes for ...
    • Chromosomal Instability in Mouse Embryonic Fibroblasts Null for the Transcriptional Co-Repressor Ski 
      Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J. (WILEY-BLACKWELL, 2012-01)
      Ski is a transcriptional regulator that has been considered an oncoprotein given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also ...
    • CK2 functionally interacts with AKT/PKB to promote the β-catenin- dependent expression of survivin and ... 
      Ponce, Daniela P.; Yefi, Roger; Cabello, Pablo; Maturana, Jose L.; Niechi, Ignacio; Silva, Eduardo; Galindo, Mario; Antonelli, Marcelo; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Tapia, Julio C. (2011)
      β-Catenin is crucial in the canonical Wnt signaling pathway. This pathway is up-regulated by CK2 which is associated with an enhanced expression of the antiapoptotic protein survivin, although the underlying molecular ...
    • Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting ... 
      Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Huerta, Hernán; Carrasco, Valentina; Villar, Paulina; Cataldo, Luis; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Varas Godoy, Manuel; Fernández, Cristina; Tapia, Julio (Impact Journals LLC, 2015)
      Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and prostate cancer cell invasion. N-terminal end of ...
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome ... 
      Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth 
      Colombo, Alicia; Palma, Karina; Armijo, Lorena; Mione, Marina; Signore, Iskra A.; Morales, Camila; Guerrero, Néstor; Meynard, Margarita M.; Pérez, Ramón; Suazo, José; Marcelain Cubillos, Katherine; Briones, Luis; Härtel, Steffen; Wilson, Stephen W.; Concha Nordemann, Miguel (The Company of Biologists, 2013)
      Although progress has been made in resolving the genetic pathways that specify neuronal asymmetries in the brain, little is known about genes that mediate the development of structural asymmetries between neurons on left ...
    • Determinación del estado mutacional de genes de relevancia oncológica en tumores de pacientes chilenos con ... 
      Miranda González, Nicolás Sebastián (Universidad de Chile, 2020)
      El cáncer de vesícula biliar (CVB) es un cáncer agresivo y de mal prognóstico, que requiere la implementación de nuevas estrategias terapéuticas. En Chile, su incidencia y mortalidad son de las más altas registradas ...
    • Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ... 
      Andaur, Rodrigo; Tapia, Julio C.; Moreno, José; Soto, Leopoldo; Armisen, Ricardo; Marcelain Cubillos, Katherine (Impact Journals LLC, 2018)
      © Andaur et al. Enhanced radiosensitivity at low doses of ionizing radiation (IR) (0.2 to 0.6 Gy) has been reported in several cell lines. This phenomenon, known as low doses hyperradiosensitivity (LDHRS), appears as an ...
    • Effect of vitamin E (DL α-tocopherol) on chromosomal damage in lymphocytes from patients with ataxia ... 
      Marcelain Cubillos, Katherine; Luz Navarrete S, Carmen; Bravo L, Mireya; Santos A, Manuel; Be R, Cecilia; Pincheira V, Juana (2002)
      Background: In ataxia telangiectasia (A-T), the lack of a functional ATM kinase is associated with disturbances in the processing of DNA damage and a chronic oxidative stress. These disturbances may be responsible for an ...
    • Epitelización inducida por células troncales derivadas del tejido adiposo 
      Meruane, M.; Benítez Seguel, Susana Alejandra; Rojas, M.; Sagredo, A.; Marcelain Cubillos, Katherine; Villalobos, B. (Sociedad Española de Cirugía Plástica, Reparadora y Estética (SECPRE), 2014)
      El tratamiento de lesiones con pérdida de tejido cutáneo ha mejorado notablemente con el advenimiento de la bioingeniería tisular. Una alternativa en desarrollo es la utilización de sustitutos dérmicos combinados con células ...
    • Estudio de la localización de la proteína SKI en nucléolos y regiones NOR en células humanas 
      Carrero Zapata, David Andrés (Universidad de Chile, 2015)
      Ski es una proteína que actúa principalmente como co-represor transcripcional, regulando negativamente la expresión de genes de respuesta en numerosas vías de señalización, incluyendo la vía de TGF-β. En los promotores ...
    • G2 checkpoint-dependent DNA repair and its response to catalase in Down syndrome and control lymphocyte cultures 
      Pincheira, Juana; Romero, Pablo; Marcelain Cubillos, Katherine; Salazar, Lorena; de la Torre, Consuelo (2007)
      The amount of DNA lesions repaired in G2 and also G2 timing are controlled by the DNA damage-dependent checkpoint. Down syndrome (DS) lymphocytes showed twice as much constitutive DNA damage in G2 than control ones, when ...
    • Identification of Ski as a target for Aurora A kinase 
      Mosquera, Jocelyn; Armisen Yáñez, Ricardo; Zhao, Hongling; Rojas, Diego A.; Maldonado, Edio; Tapia, Julio C.; Colombo, Alicia; Hayman, Michael J.; Marcelain Cubillos, Katherine (2011)
      Ski is a negative regulator of the transforming growth factor-β and other signalling pathways. The absence of SKI in mouse fibroblasts leads to chromosome segregation defects and genomic instability, suggesting a role for ...
    • In vitro irradiation of colorectal cancer cells by pulsed radiation emitted from a hundred joules plasma ... 
      Jain, J.; Moreno, J.; Andaur, R.; Armisen, R.; Avaria, G.; Bora, B.; Davis, S.; Pavez, C.; Marcelain Cubillos, Katherine; Soto, L. (Institute of Physics Publishing, 2018)
      In the last years, pulsed reduced low dose radiation has been proposed as an alternative for treatment of recurrent cancer. Nonetheless, distinction between the effects of low dose pulsed and continuous radiation is barely ...
    • Parity modulates the ovarian transcriptome and systemic inflammatory markers in estropausal mice 
      Urzúa Tobar, Ulises; Chacón, C.; Sarmiento, S.; Lizama, L.; Ampuero, S.; Marcelain Cubillos, Katherine; Villalobos, P.; González, M. J.; Romero Osses, Carmen (Lippincott Williams & Wilkins, 2015)
    • Participación del co-represor ski en el mantenimiento de la heterocromatina pericentromérica en modelo de ... 
      Pola Véliz, Víctor Giovanni (Universidad de Chile, 2017)
      Ski es un co-represor transcripcional de la via de señalización TGFβ, entre otras. En fibroblastos embrionarios de ratón (MEFs), la ausencia de Ski induce a defectos en la segregación cromosómica, alteraciones de SAC y ...
    • Protein kinase CK2 promotes cancer cell viability via up-regulation of cyclooxygenase-2 expression and ... 
      Yefi, Roger; Ponce, Daniela P.; Niechi, Ignacio; Silva, Eduardo; Cabello, Pablo; Rodriguez, Diego A.; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Quest, Andrew F. G.; Tapia, Julio C. (2011)
      Augmented expression of protein kinase CK2 is associated with hyperproliferation and resistance to apoptosis in cancer cells. Effects of CK2 are at least partially linked to signaling via the Wnt/β-catenin pathway, which ...
    • The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A 
      Rivas, Solange; Armisen Yáñez, Ricardo; Rojas, Diego A.; Maldonado Maldonado, Edio; Huerta, Hernán; Tapia, Julio C.; Espinoza, Jaime; Colombo, Alicia; Michea Acevedo, Luis; Hayman, Michael J.; Marcelain Cubillos, Katherine (Wiley & Sons, 2016)
      Oncogenic kinase Aurora A (AURKA) has been found to be overexpresed in several tumors including colorectal, breast, and hematological cancers. Overexpression of AURKA induces centrosome amplification and aneuploidy and it ...
    • The use of adipose tissue-derived stem cells within a dermal substitute improves skin regeneration by ... 
      Meruane, Manuel A.; Rojas, Mariana; Marcelain Cubillos, Katherine (2012)
      BACKGROUND: Surgical treatment of injuries with loss of skin tissue has improved significantly with the advent of regenerative medicine and tissue bioengineering, and the use of stem cells and dermal substitutes. The success ...