Browsing by Author "Martínez Winkler, Jorge"
Now showing items 1-17 of 17
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Villarroel, Pia; Reyes Jedlicki, Marcela; Fuentes, Cecilia; Segovia, María Pia; Tobar, Nicolás; Villalobos, Elisa; Martínez Winkler, Jorge; Hugo, Eric; Ben-Jonathan, Nira; Cifuentes, Mariana (Springer, 2013)We established that human adipose cells and the human adipose cell line LS14 express the calciumsensing receptor (CaSR) and that its activation induces inflammatory cytokine production. Also, its expression is enhanced ...
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BONE EXTRACELLULAR MATRIX STIMULATES INVASIVENESS OF ESTROGEN-RESPONSIVE HUMAN MAMMARY MCF-7 CELLS Martínez Winkler, Jorge; Fuentes, Mauricio; Cambiazo Ayala, Liliana; Santibáñez, J. Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1999-10-08)Bone is the most frequent site of metastasis in breast cancer. This causes destructive osteolytic lesions. To achieve metastasis to bone, breast cancer cells must proliferate in a new microenvironment, arrest on ...
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Cáceres Lluch, Mónica Andrea (Universidad de Chile, 2011)Se ha propuesto el empleo de factores solubles derivados de plaquetas con el objeto de promover la reparación de tejidos. A pesar que diversos estudios han evaluado la respuesta de células gingivales y periodontales a ...
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Miller Vargas, Constanza Andrea (Universidad de Chile, 2014)
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Cáceres, Mónica; Martínez, Constanza; Martínez Winkler, Jorge; Smith, Patricio (2012)Objectives: Although platelet-rich plasma (PRP) has been proposed as a therapeutic tool to enhance wound repair, the cellular and molecular mechanisms stimulated by this agent are still not completely understood. The ...
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Guerrero, Javier; Santibáñez, Juan Francisco; González, Alfonso; Martínez Winkler, Jorge (Elsevier Inc., 2004)Urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) are ubiquitous receptors involved in the control of a variety of cellular processes frequently found altered in cancer cells. ...
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Carvajal Baeza, Nelson; Acoria García, Marina; Rodríguez Vives, Juan Pablo; Fernández Gálvez, Mireya; Martínez Winkler, Jorge (1982)The reaction kinetics of human liver arginase (l-arginine amidinohydrolase, EC 3.5.3.1) in terms of arginine concentration is strikingly altered by varying the pH. Lowering the pH from the optimum (9.5) toward a more ...
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Kallens Meza, Violeta Natalia (Universidad de Chile, 2016)La exposicion cronica a una alta concentracion de glucosa ha sido asociada con el desarrollo de estrés oxidativo, inflamación, ambos precursores potenciales de cáncer mamario. Datos epidemiologicos han permitido asociar ...
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Smith Schuster, Patricio Fernando; Cáceres, Mónica; Martínez Winkler, Jorge (Blackwell Munksgaard Ltd, 2006-06-05)Myofibroblastic differentiation is an important event in gingival wound healing and chronic inflammation. Transforming frowth factorb 1 (TGF-b1) is a potent growth factor that has been implicated in this process. Gingival ...
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Cáceres Lluch, Mónica Andrea (Universidad de Chile, 2004)La expresión de propiedades malignas en células epiteliales supone la puesta en marcha de una serie de cambios fenotípicos, que confieren a las células propiedades especificas que permiten la migración y degradación de ...
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Rodríguez Piccoli, Guillermo Antonio (Universidad de Chile, 2010)
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Toyos Riera, Marcela Alejandra (Universidad de Chile, 2013)Brest tumors belong to a group of neoplastic lesions known as desmoplastics or scirrhous tumors which, under the influence of tumor cell factors, originate a fibrous structure responsible for the hard consistency of the ...
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Martínez Winkler, Jorge; Silva, Sofía; Santibáñez, Juan Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1996-04)Bone metastasis is a common event and a major cause of morbidity in prostate cancer patients. After colonization of bone, prostate cells induce an osteoblastic reaction which is not associated with marrow fibrosis ...
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Tobar Bachler, Nicolás Andrés (Universidad de Chile, 2008)
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El receptor de EGF media, los efectos de TGF-B1 sobre la malignidad de queratinocitos transformados Farfán Becerra, Nicole Elisa (Universidad de Chile, 2008)En la enfermedad cancerosa, la célula tumoral manifiesta una serie de alteraciones funcionales y morfologicas, que le permiten tanto el crecimiento autonomo como la movilizacion a tejidos distantes. EI Factor de Crecimiento ...
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Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar Oliva, Paula; Dotor, Javier; Smith, Patricio C.; Martínez Winkler, Jorge (Springer Science+Business Media, 2011)In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic response. ...
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Smith, P. C.; Guerrero, J.; Tobar, N.; Cáceres, M.; González Burgos, María Julieta; Martínez Winkler, Jorge (Blackwell Munksgaard, 2007-12-11)Membrane type 1-matrix metalloproteinase (MT1- MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the production of proteolytic ...