Browsing by Author "Mendoza Naranjo, Ariadna"

Now showing items 1-12 of 12

    • A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-β+ ... 
      López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Aβ1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases 
      Mendoza Naranjo, Ariadna; González Billault, Christian; Maccioni Baraona, Ricardo (2007)
      A number of psychiatric and neurodegenerative disorders, such as Alzheimer's disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced by ...
    • A beta(1-42) stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases 
      Mendoza Naranjo, Ariadna; González Billault, Christian; Maccioni Baraona, Ricardo (COMPANY OF BIOLOGISTS LTD, 2006-10-30)
      A number of psychiatric and neurodegenerative disorders, such as Alzheimer’s disease, are characterized by abnormalities in the neuronal cytoskeleton. Here, we find that the enhancement in actin polymerization induced ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 
      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • Functional gap junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells 
      Mendoza Naranjo, Ariadna; Sáez, Pablo J.; Johansson, C. Christian; Ramírez Fernández, Marcos; Mandakovic Seyler, Dinka; Pereda, Cristián; López Nitsche, Mercedes; Kiessling, Rolf; Sáez, Juan C.; Salazar Onfray, Flavio (2007)
      Previously, we found that human dendritic cells (hDCs) pulsed with a melanoma cell lysate (MCL) and stimulated with TNF-ce (MCL/TNF) acquire a mature phenotype in vitro and are able to trigger tumor-specific immune responses ...
    • Gap junction intercellular communications regulate NK cell activation and modulate NK cytotoxic capacity 
      Tittarelli, Andrés; Mendoza Naranjo, Ariadna; Farías, Marcela; Guerrero, Israel; Ihara, Fumitaka; Wennerberg, Erik; Riquelme, Sebastián; Gleisner, Alejandra; Kalergis, Alexis; Lundqvist, Andreas; López Nitsche, Mercedes; Chambers, Benedict J.; Salazar Onfray, Flavio (The American Association of Immunologists, 2014)
      Gap junctions (GJs) mediate intercellular communication between adjacent cells. Previously, we showed that connexin 43 (Cx43), the main GJ protein in the immune system, mediates Ag transfer between human dendritic cells ...
    • Heat-Shock Induction of Tumor-Derived Danger Signals Mediates Rapid Monocyte Differentiation into Clinically ... 
      Aguilera, Raquel; Saffie, Carlos; Tittarelli, Andrés; González Bergas, Fermín; Ramírez Fernández, Marcos; Reyes, Diego; Pereda, Cristián; Hevia, Daniel; García, Tamara; Salazar, Lorena; Ferreira Vigouroux, Luis Arturo; Hermoso Ramello, Marcela; Mendoza Naranjo, Ariadna; Ferrada, Carlos; Garrido, Paola; López Nitsche, Mercedes; Salazar Onfray, Flavio (AMER ASSOC CANCER RESEARCH, 2011-04-15)
      Purpose: This study characterizes, biologically and clinically, a novel type of dendritic cells (DC) produced in the short term and called tumor antigen–presenting cells (TAPCells). In particular, we identified factors ...
    • Interleukin 10 decreases MICA expression on melanoma cell surface 
      Serrano, Antonio E.; Menares Castillo, Evelyn; Garrido Tapia, Macarena; Hager Ribeiro, Carolina; Hernández, Carolina J.; Mendoza Naranjo, Ariadna; Gatica Andrades, Marcela; Valenzuela Díaz, Rodrigo; Zúñiga, Roberto; López, Mercedes N.; Salazar Onfray, Flavio; Aguillón, Juan Carlos (2011)
      Natural-killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC) class I chain-related proteins (MIC) and UL16-binding proteins (ULBP). It is regarded as a ...
    • Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for ... 
      López, Mercedes N.; Pereda, Cristian; Ramírez, Marcos; Mendoza Naranjo, Ariadna; Serrano, Antonio; Ferreira, Arturo; Poblete, Rodrigo; Kalergis, Alexis M.; Kiessling, Rolf; Salazar Onfray, Flavio (2007)
      PURPOSE. Uveal melanoma is the most common primary malignant ocular cancer in adults. This tumor has a distinct expression pattern of markers compared with cutaneous melanoma. MC1R is under study as a potential target ...
    • Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape 
      Salazar Onfray, Flavio; López Nitsche, Mercedes; Mendoza Naranjo, Ariadna (2007)
      The role of cytokines in modulating the formation of new tumors is mediated by their ability to regulate antigen-specific anti-tumor responses and by the activation of non-specific mechanisms, including those involved in ...
    • Prolonged survival of dendritic cell-vaccinated melanoma patients correlates with tumor-specific delayed ... 
      López, Mercedes N.; Pereda, Cristian; Segal, Gabriela; Muñoz, Leonel; Aguilera, Raquel; González, Fermín E.; Escobar, Alejandro; Ginesta, Alexandra; Reyes, Diego; González, Rodrigo; Mendoza Naranjo, Ariadna; Larrondo, Milton; Compán, Alvaro; Ferrada, Carlos; Salazar Onfray, Flavio (2009)
      Purpose The aim of this work was to assess immunologic response, disease progression, and posttreatment survival of melanoma patients vaccinated with autologous dendritic cells (DCs) pulsed with a novel allogeneic cell ...
    • The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines 
      López, Mercedes; Aguilera, Raquel; Pérez Núñez, Claudio; Mendoza Naranjo, Ariadna; Pereda, Cristian; Ramirez, Marcos; Ferrada, Carlos; Aguillón Gutiérrez, Juan Carlos; Salazar Onfray, Flavio (Elsevier GmbH, 2006)
      Immunotherapy has become a novel therapeutic alternative for various kinds of tumours. Recently, we have finalized the first phase I clinical study in Chile for the treatment of advanced malignant melanoma, using dendritic ...