The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines
Artículo
Open/ Download
Publication date
2006Metadata
Show full item record
Cómo citar
López, Mercedes
Cómo citar
The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines
Author
Abstract
Immunotherapy has become a novel therapeutic alternative for various kinds of tumours. Recently, we have finalized the first phase I clinical study in Chile for the treatment of advanced malignant melanoma, using dendritic cells (DCs) loaded with allogeneic melanoma cell lysate. This study included 20 patients and the obtained results, pioneer in Latin America, showed that DC-based immunotherapy is innocuous, even provided in combination with IL-2. In addition, immunological responses were detected in 50% of the treated patients, establishing a positive correlation between the delayed type hypersensitivity (DTH) reaction, which indicates induction of in vivo immunological memory, and patients surviving. Nevertheless, objective clinical responses in vaccinated patients are still insufficient. Only sporadic objective metastasis regressions have been registered and an important proportion of the treated patients did not respond, or their responses were weak. Several strategies have been d
Indexation
Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/163959
DOI: 10.1016/j.imbio.2005.11.003
ISSN: 01712985
Quote Item
Immunobiology, Volumen 211, Issue 1-2, 2018, Pages 127-136
Collections