Browsing by Author "Montecino, Martín"

Now showing items 1-13 of 13

    • Calcium/calmodulin-dependent protein kinase type IV Is a target gene of the Wnt/β-catenin signaling pathway 
      Arrázola, Macarena S.; Varela Nallar, Lorena; Colombres, Marcela; Toledo, Enrique M.; Cruzat, Fernando; Pavez, Leonardo; Assar, Rodrigo; Aravena, Andrés; González, Mauricio; Montecino, Martín; Maass Sepúlveda, Alejandro; Martínez Aguilera, Servet; Inestrosa, Nibaldo C. (2009)
      Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory ...
    • Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone ... 
      Rojas, Adriana; Aguilar, Rodrigo; Henríquez, Berta; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; Wijnen, Andre J. van; Zundert, Brigitte van; Allende Connelly, Miguel; Montecino, Martín (The American Society for Biochemistry and Molecular Biology, 2015)
      Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional activation and repression ...
    • Expression of the ectodomain-releasing protease ADAM17 is directly regulated by the osteosarcoma and ... 
      Araya López, Héctor; Sepulveda, Hugo; Lizama, Carlos O.; Vega Villa, Oscar; Jerez, Sofia; Briceño, Pedro F.; Thaler, Roman; Riester, Scott M.; Antonelli Anativia, Marcelo; Salazar Onfray, Flavio; Rodríguez Vives, Juan Pablo; Moreno, Ricardo D.; Montecino, Martín; Charbonneau, Martine; Dubois, Claire; Galindo Díaz, Mario; Stein, Gary; van Wijnen, Andre (Wiley-Liss Inc., 2018)
      Osteoblast differentiation is controlled by transcription factor RUNX2 which temporally activates or represses several bone-related genes, including those encoding extracellular matrix proteins or factors that control ...
    • Global gene expression analysis provides insight into local adaptation to geothermal streams in tadpoles ... 
      Pastenes, Luis; Valdivieso, Camilo; Di Genova, Alex; Travisany, Dante; Hart, Andrew; Montecino, Martín; Orellana, Ariel; Gonzalez, Mauricio; Gutiérrez, Rodrigo A.; Allende Connelly, Miguel; Maass Sepúlveda, Alejandro; Méndez, Marco A. (Nature Publishing Group, 2017)
      © 2017 The Author(s). The anuran Rhinella spinulosa is distributed along the Andes Range at altitudes that undergo wide daily and seasonal variation in temperature. One of the populations inhabits geothermal streams, a ...
    • Identification of a novel long noncoding RNA that promotes osteoblast differentiation 
      Nardocci, Gino; Carrasco, Margarita E.; Acevedo, Elvis; Hodar, Christian; Meneses, Claudio; Montecino, Martín (Wiley-Liss Inc., 2018)
      © 2018 Wiley Periodicals, Inc. Long noncoding RNAs (lncRNAs) are a heterogeneous class of transcripts, longer than 200 nucleotides, 5′-capped, polyadenylated, and poorly conserved among mammalian species. Several studies ...
    • Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor ... 
      Varela Figueroa, Nelson; Aránguiz Quezada, Katherine Alejandra; Lizama, Carlos; Sepúlveda, Hugo; Antonelli Anativia, Juan; Thaler, Román; Moreno, Ricardo D.; Montecino, Martín; Stein, Gary S.; Van Wijnen, Andre; Galindo Díaz, Mario (Wiley-Blackwell, 2016)
      Epigenetic mechanisms mediate the acquisition of specialized cellular phenotypes during tissue development, maintenance and repair. When phenotype-committed cells transit through mitosis, chromosomal condensation counteracts ...
    • Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2 
      Young, Daniel W.; Hassan, Mohammad Q.; Yang, Xiao Qing; Galindo, Mario A.; Javed, Amjad; Zaidi, Sayyed K.; Furcinitti, Paul; Lapointe, David; Montecino, Martín; Lian, Jane B.; Stein, Janet L.; Van Wijnen, Andre J.; Stein, Gary S. (2007)
      During cell division, cessation of transcription is coupled with mitotic chromosome condensation. A fundamental biological question is how gene expression patterns are retained during mitosis to ensure the phenotype of ...
    • Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 ... 
      Rojas, Adriana; Sepúlveda, Hugo; Henríquez, Berta; Aguilar, Rodrigo; Opazo, Tatiana; Nardocci, Gino; Bustos, Fernando; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; van Zundert, Brigitte; van Wijnen, Andre J.; Allende Connelly, Miguel; Montecino, Martín (Wiley, 2019)
      Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic ...
    • Prenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral ... 
      Palacios García, Ismael; Lara Vásquez, Ariel; Montiel, Juan F.; Díaz Véliz, Gabriela; Sepúlveda, Hugo; Utreras Puratich, Elías; Montecino, Martín; González Billault, Christian; Aboitiz Domínguez, Francisco Javier (Public Library Science, 2015)
      Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia. The extracellular ...
    • Regulation of the intestinal extra-adrenal steroidogenic pathway component LRH-1 by glucocorticoids in ... 
      Landskron Ramos, Glauben Tamara; Dubois Camacho, Karen; Orellana Serradell, Octavio Andrés; Fuente López, Majorie de la; Parada Venegas, Daniela Estefani; Bitrán Ambler, Mirit Luisa; Díaz Jiménez, David; Tang, Shuang; Cidlowski, John A.; Li, Xiaoling; Molina, Héctor; González, Carlos M.; Simian, Daniela; Lubascher, Jaime; Pola, Víctor; Montecino, Martín; Blokzijl, Tjasso; Faber, Klaas Nico; González Burgos, María Julieta; Quera, Rodrigo; Hermoso, Marcela Alejandra (MDPI, 2022)
      Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) and can be treated with glucocorticoids (GC), although some patients are unresponsive to this therapy. The transcription factor LRH-1/NR5A2 is critical to ...
    • The Specification of Cortical Subcerebral Projection Neurons Depends on the Direct Repression of TBR1 by ... 
      Cánovas, José; Berndt, F. Andrés; Sepúlveda, Hugo; Aguilar, Rodrigo; Veloso, Felipe A.; Montecino, Martín; Oliva, Carlos; Maass Oñate, Juan; Sierralta Jara, Jimena; Kukuljan Padilla, Manuel (Soc. Neuroscience, 2015)
      The acquisition of distinct neuronal fates is fundamental for the function of the cerebral cortex. We find that the development of subcerebral projections from layer 5 neurons in the mouse neocortex depends on the high ...
    • Symbolic Extensions Applied to Multiscale Structure of Genomes 
      Downarowicz, Tomasz; Travisany, Dante; Montecino, Martín; Maass Sepúlveda, Alejandro (Kluwer Academic Publishers, 2014)
      A genome of a living organism consists of a long string of symbols over a finite alphabet carrying critical information for the organism. This includes its ability to control post natal growth, homeostasis, adaptation to ...
    • The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development 
      Lopez, Cecilia I.; Saud, Katherine E.; Aguilar, Rodrigo; Berndt, F. Andrés; Cánovas, José; Montecino, Martín; Kukuljan, Manuel (John Wiley and Sons Inc., 2016)
      © 2016 Wiley Periodicals, Inc. The development of the cerebral cortex is a dynamic and coordinated process in which cell division, cell death, migration, and differentiation must be highly regulated to acquire the final ...