Browsing by Author "Ohlmann, Théophile"

Now showing items 1-3 of 3

    • The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized ... 
      Soto Rifo, Ricardo; Rubilar, Paulina S.; Ohlmann, Théophile (Oxford University Press, 2013)
      Here, we show a novel molecular mechanism promoted by the DEAD-box RNA helicase DDX3 for translation of the HIV-1 genomic RNA. This occurs through the adenosine triphosphate-dependent formation of a translation initiation ...
    • DEAD-box RNA helicase DDX3 connects CRM1-dependent nuclear export and translation of the HIV-1 unspliced ... 
      Fröhlich, Alvaro; Rojas Araya, Bárbara; Pereira Montecinos, Camila; Dellarossa, Alessandra; Toro Ascuy, Daniela; Prades Pérez, Yara; García de Gracia, Francisco; Garcés Alday, Andrea; Rubilar, Paulina S.; Valiente Echeverría, Fernando; Ohlmann, Théophile; Soto Rifo, Ricardo (2016)
      DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel therapies aimed to overcome viral resistance. Previous studies have shown that DDX3 promotes nuclear ...
    • HIV-2 genomic RNA accumulates in stress granules in the absence of active translation 
      Soto Rifo, Ricardo; Valiente Echeverría, Fernando Andrés; Rubilar, Paulina S.; Garcia-de-Gracia, Francisco; Ricci, Emiliano P.; Limousin, Taran; Décimo, Didier; Mouland, Andrew J.; Ohlmann, Théophile (2014)
      During the post-transcriptional events of the HIV-2 replication cycle, the full-length unspliced genomic RNA (gRNA) is first used as an mRNA to synthesize Gag and Gag-Pol proteins and then packaged into progeny virions. ...