Now showing items 1-20 of 133

    • Cerecetto, Hugo; González, M.; Risso, Mariela; Saenz, P.; Olea Azar, Claudio; Bruno, A. M.; Azqueta, Amaia; De Cerain, A. L.; Monge, A. (WILEY-V C H VERLAG GMBH, 2004-05)
      New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins. The desired products were obtained when the 5-methyl heterocycle ...
    • Mera, Raúl; Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Miranda Rojas, Sebastián; Fuentealba Rosas, Patricio (AMER CHEMICAL SOC, 2011-05-05)
      Bond order indexes are useful measures that connect quantum mechanical results with chemical understanding. One of these measures, the natural bond order index, based on the natural resonance theory procedure and part of ...
    • Figueroa Benavides, Catalina Paz (Universidad de Chile, 2018)
      La diabetes mellitus de tipo dos (DMT2) es una enfermedad metabólica caracterizada por un incremento crónico de la glicemia y un desequilibrio oxidativo que a largo plazo conllevan a la aparición de una serie de ...
    • Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Rocha Ferreira, Fabricia da; Barros Valentim, Iara; Catarí Ramones, Edgar Luís; Salles Trevisan, Maria Teresa; Olea Azar, Claudio; Pérez Cruz, Fernanda; Caxico de Abreu, Fabiane; Fonseca Goulart, Marília Oliveira (Elsevier, 2012-09-28)
      The aim of this study was to characterize the complex between mangiferin (MGN) with beta-cyclodextrin (beta-CD) obtained through the co-evaporation method using Differential Scanning Calorimetry (DSC) and Fourier Transform ...
    • Rodríguez Borges, Jorge; Olea Azar, Claudio; Cavieres, C.; Norambuena, Ester; Delgado Castro, Tomás; Soto Delgado, Jorge; Araya Maturana, Ramiro (PERGAMON-ELSEVIER SCIENCE LTD, 2007-11-15)
      This study was undertaken to investigate the free radical -scavenging and antioxidant activities of various structurally related hydroquinones including hydroxynaplithalenones and dihydroxyanthracenones. Electron spin ...
    • Eisner, Verónica; Quiroga Lagos, Clara; Criollo Céspedes, Alfredo; Olea Azar, Claudio; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 2004)
      Meeting Abstract
    • Olea Azar, Claudio; Rigol, C.; Mendizábal Emaldía, Fernando; Briones, R. (2006)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo (BENTHAM SCIENCE PUBL LTD, 2006-02)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • Mendizábal Emaldía, Fernando; Olea Azar, Claudio (2002)
      To facilitate a rational basis set selection for B3LYP studies of organic reactions in the interstellar medium, we analyzed energetic parameters for the main stationary points in the reaction HN=CH2 + •C≡N → H2N-C(•)H-C≡N ...
    • Díaz Urrutia, Christian; Olea Azar, Claudio; Zapata, Gerald A.; Lapier, Michel; Mura Mardones, Francisco; Aguilera Venegas, Benjamín; Arán, Vicente J.; López Muñoz, Rodrigo; Maya Arango, Juan (2012)
      A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
    • Sobarzo Sánchez, Eduardo; Olea Azar, Claudio; Alarcón, Jaime; Opazo, Lucía; Cassels Niven, Bruce (2003)
      The electrochemical behavior of two representative 2,3-dihydro-7H-dibenzo[de,h]quinolin-7-ones was determined using cyclic voltammetry in DMSO as solvent and rationalized by quantum chemical calculations using ab initio ...
    • Villena, Joan; Henríquez Luna, Mauricio; Torres Gómez, Vicente; Moraga, Francisco; Díaz Elizondo, Jessica; Arredondo, Cristian; Chiong Lay, Mario; Olea Azar, Claudio; Stutzin Schottlander, Andrés; Lavandero González, Sergio; Quest, Andrew F. G. (ELSEVIER SCIENCE INC, 2008-03-15)
      In lymphocytes, Fas activation leads to both apoptosis and necrosis, whereby the latter form of cell death is linked to delayed production of endogenous ceramide and is mimicked by exogenous administration of long- and ...
    • Jullian Matthaei, Carolina; Morales Montecinos, Javier; Zapata Torres, Gerald Amilcar; Aguilera, Benjamín; Rodríguez Borges, Jorge; Arán, Vicente J.; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-05-01)
      The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either beta-cyclodextrin (beta CD) or Heptakis (2,6-di-O-methyl)-beta- cyclodextrin (DM beta CD) were investigated. The stoichiometric ...
    • Zúñiga López, María C.; Laurie, V. Felipe; Barriga González, Germán; Folch Cano, Christian; Fuentes, Jocelyn; Agosin Trumper, Eduardo; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Since the early 1990s, a meaningful number of reports have been published supporting the idea that wines, especially reds, encompass a series of bioactive compounds, mainly phenolic ...
    • Leal, D.; Mansilla, A.; Matsuhiro, B.; Moncada-Basualto, Mauricio; Lapier, M.; Maya Arango, Juan; Olea Azar, Claudio; De Borggraeve, W. M. (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded ...
    • Norambuena V., Ester; Olea Azar, Claudio; Delgadillo, Alvaro; Barrera, Mauricio; Loeb, Bárbara (ELSEVIER SCIENCE BV, 2009-05-18)
      The reduction properties of four acceptor polipyridyl ligands modified with quinones were studied by different experimental methods, as cyclic voltammetry and ESR spectroscopy, and by theoretical calculations. ESR spectra ...
    • Olea Azar, Claudio; Parra Mouchet, Julia (Sociedad Chilena de Química, 1999)
      This paper presents SCF AM1 and CNDO/2 RF calculations of the potential energy surface of histamine monocation (HA) and the agonists 2-(4-thiazolyl)ethylamine (TIA) and 2-(4-oxazolyl)ethylamine (OXA). the similarity of ...
    • Rodríguez Borges, Jorge; Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • Jullian Matthaei, Carolina; Orosteguis, Teresita; Pérez Cruz, Fernanda; Sánchez, Paulina; Mendizábal Emaldía, Fernando; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-11-01)
      Properties of inclusion complexes between morin (M) and beta-cyclodextrin (beta CD), 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) and Heptakis (2,6-O-di methyl) beta-cycloclextrin (DM beta CD) such as aqueous solubility ...