Browsing by Author "Owen, Gareth I."

Now showing items 1-8 of 8

    • Antiangiogenic, antimigratory and antiinflammatory effects of 2-methoxyestradiol in zebrafish larvae 
      Quezada, Marisol; Alvarez, Marjorie; Peña, Oscar A.; Henríquez, Soledad; Alençon, Claudia A. d'; Lange, Soledad; Oliva, Barbara; Owen, Gareth I.; Allende Connelly, Miguel (Elsevier, 2012-11-07)
      2-Methoxyestradiol (2ME), an endogenous metabolite of 17β-estradiol, has been previously reported to possess antiangiogenic and antitumor properties. Herein, we demonstrate that the effects of this antiangiogenic steroid ...
    • Biomarcadores farmacogenómicos para reacciones adversas a quimioterapéuticos en pacientes con cáncer gástrico ... 
      Córdova Delgado, Miguel (Universidad de Chile, 2020)
      Introducción: El tratamiento estándar de primera línea en pacientes con cáncer gástrico consiste en regímenes de quimioterapias combinadas, en donde se incluyen generalmente fluoropirimidinas y platinos, sin embargo, la ...
    • Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial ... 
      Díaz Valdivia, Natalia; Bravo, Denisse; Huerta, Hernán; Henríquez, Soledad; Gabler Neale, Fernando; Vega Blanco, María Margarita; Romero Osses, Carmen; Calderón, Claudia; Owen, Gareth I.; Leyton Campos, Lisette; Quest, Andrew F. G. (BioMed Central, 2015)
      Background: Caveolin-1 (CAV1) has been implicated both in tumor suppression and progression, whereby the specific role appears to be context dependent. Endometrial cancer is one of the most common malignancies of the female ...
    • Identification of novel 11b-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristóbal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia Castillo, Alejandra; Baudrand, René; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; Fardella, Carlos E. (Elsevier, 2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11b-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Mechanobiology of autophagy: the unexplored side of cancer 
      Hernández Cáceres, María Paz; Muñoz, Leslie; Pradenas, Javiera M.; Pena, Francisco; Lagos, Pablo; Aceiton, Pablo; Owen, Gareth I.; Morselli, Eugenia; Criollo Céspedes, Alfredo Guillermo; Ravasio, Andrea; Bertocchi, Cristina (Frontiers Media, 2021)
      Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses. Cancer ...
    • MicroRNA-335-5p is a potential suppressor of metastasis and invasion in gastric cancer (vol 9, 114, 2017) 
      Sandoval Bórquez, Alejandra; Polakovicova, Iva; Carrasco Véliz, Nicolás; Lobos González, Lorena; Riquelme, Ismael; Carrasco Avino, Gonzalo; Bizama Soto, Carolina del Carmen; Norero, Enrique; Owen, Gareth I.; Roa Strauch, Juan Carlos; Corvalán, Alejandro H. (BMC, 2021)
    • Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants ... 
      Orellana, Renán; Kato, Sumie; Erices, Rafaela; Bravo, María Loreto; González, Pamela; Oliva, Bárbara; Cubillos, Sofía; Valdivia, Andrés; Ibáñez, Carolina; Brañes, Jorge; Barriga, María Isabel; Bravo, Erasmo; Alonso, Catalina; Bustamente, Eva; Castellón, Enrique; Hidalgo, Patricia; Trigo, César; Panes, Olga; Pereira, Jaime; Mezzano, Diego; Cuello, Mauricio A.; Owen, Gareth I. (BioMed Central, 2015)
      Background: An increase in circulating platelets, or thrombocytosis, is recognized as an independent risk factor of bad prognosis and metastasis in patients with ovarian cancer; however the complex role of platelets in ...
    • A snapshot of cancer in Chile: analytical frameworks for developing a cancer policy 
      Jiménez de la Jara, Jorge; Bastías, Gabriel; Ferreccio, Catterina; Moscoso, Cristian; Sagues, Sofía; Cid, Camilo; Bronstein, Eduardo; Herrera, Cristian; Nervi, Bruno; Corvalán, Alejandro; Velásquez, Ethel V.; González, Pamela; Castellón Vera, Enrique; Bustamante, Eva; Oñate, Sergio; McNerney, Eileen; Sullivan, Richard; Owen, Gareth I. (BioMed Central, 2015)
      Introduction: The South American country Chile now boasts a life expectancy of over 80 years. As a consequence, Chile now faces the increasing social and economic burden of cancer and must implement political policy to ...