Now showing items 1-19 of 19

    • Chiong Lay, Mario; Wang, Z. V.; Pedrozo Cibils, Zully; Cao, D. J.; Troncoso, R.; Ibacache, M.; Criollo, A.; Nemchenko, A.; Hill, J. A.; Lavandero González, Sergio (2011)
      Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, ...
    • Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Ibacache Figueroa, Mauricio; Sánchez, Gina; Gálvez, Felipe; Pedrozo Cibils, Zully; Humeres Martínez, Claudio; Echevarría, Ghislaine; Duaso, Juan; Hassi, Mario; García Nannig, Lorena; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2012-04)
      Pharmacological preconditioning limits myocardial infarct size after ischemia/reperfusion. Dexmedetomidine is an alpha(2)-adrenergic receptor agonist used in anesthesia that may have cardioprotective properties against ...
    • Riquelme, Jaime; Westermeier, Francisco; Hall, Andrew R.; Vicencio, Jose; Pedrozo Cibils, Zully; Ibacache, Mauricio; Fuenzalida, Barbara; Sobrevia, Luis; Davidson, Sean M.; Yellon, Derek M.; Sánchez, Gina; Lavandero González, Sergio (Elsevier, 2016)
      The alpha2-adrenergic receptor agonist Dexmedetomidine (Dex) is a sedative medication used by anesthesiologists. Dex protects the heart against ischemia-reperfusion (IR) and can also act as a preconditioning mimetic. The ...
    • Bravo Sagua, Roberto; Gutiérrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodríguez, Andrea E.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Parra, Valentina; Quest, Andrew F. G.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
      Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged ...
    • Oyarzún, Alejandra P.; Westermeier, Francisco; Pennanen, Christian; López Crisosto, Camila; Parra, Valentina; Sotomayor Flores, Cristian; Sánchez, Gina; Pedrozo Cibils, Zully; Troncoso Cotal, Rodrigo; Lavandero González, Sergio (Elsevier, 2015)
      Aim: FK866 is an inhibitor of the NAD(+) synthesis rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and ...
    • Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Xie, Min; Kong, Yongli; Tan, Wei; May, Herman; Battiprolu, Pavan K.; Pedrozo Cibils, Zully; Wang, Zhao V.; Morales, Cyndi; Luo, Xiang; Cho, Geoffrey; Jiang, Nan; Jessen, Michael E.; Warner, John J.; Lavandero González, Sergio; Gillette, Thomas G.; Turer, Aslan T.; Hill, Joseph A. (American Hearth Association, 2014)
      Background—Reperfusion accounts for a substantial fraction of the myocardial injury occurring with ischemic heart disease. Yet, no standard therapies are available targeting reperfusion injury. Here, we tested the hypothesis ...
    • Morales, Cyndi R.; Li, Dan L.; Pedrozo Cibils, Zully; May, Herman I.; Jiang, Nan; Kyrychenko, Viktoriia; Cho, Geoffrey; Kim, Soo Young; Wang, Zhao V.; Rotter, David; Rothermel, Beverly A.; Schneider, Jay W.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Amer Assoc Advancement Science, 2016)
      Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...
    • Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Torrealba Cárdenas, Natalia Belén (Universidad de Chile, 2011-12)
      El receptor de ryanodina tipo 2 (RyR2) desempeña un papel crucial en el corazón ya que permite la salida de calcio desde el retículo sarcoplasmático para activar la contracción, por tanto la regulación de sus niveles es ...
    • Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Galvis Pareja, David; Zapata Torres, Gerald; Hidalgo Tapia, Jorge; Ayala, Pedro; Pedrozo Cibils, Zully; Ibarra, Cristián; Díaz Araya, Guillermo; Hall, Andrew R.; Vicencio, José Miguel; Núñez Vergara, Luis; Lavandero González, Sergio (Elsevier, 2014)
      Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
    • Gatica Mizala, Damián (Universidad de Chile, 2012)
      La autofagia es un proceso fisiológico clave para la sobrevida celular frente a diferentes tipos de estrés. Este proceso degradativo consiste en el reclutamiento de proteínas, lípidos y organelos completos en vesículas de ...
    • Romero Romano, Pablo (Universidad de Chile, 2017)
      Las enfermedades cardiovasculares corresponden a una de las mayores causas de muerte en el mundo, donde el infarto agudo del miocardio es responsable de la mayoría de ellas. Diferentes vías confluyen en el daño y muerte ...
    • Poblete Guzmán, Felipe Ignacio (Universidad de Chile, 2020)
      La Policistina-1 (PC1) es un mecanosensor fundamental para la correcta contractilidad cardiaca y su ausencia en los cardiomiocitos se relaciona con la disminución de los niveles proteicos de los canales de calcio tipo-L ...
    • Pedrozo Cibils, Zully; Criollo Céspedes, Alfredo; Battiprolu, Pavan K.; Morales, Cyndi R.; Contreras Ferrat, Ariel Eduardo; Fernández, Carolina; Jiang, Nan; Luo, Xiang; Caplan, Michael J.; Somlo, Stefan; Rothermel, Beverly A.; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Lippicott Williams & Wilkins, 2015)
      Background-L-type calcium channel activity is critical to afterload-induced hypertrophic growth of the heart. However, the mechanisms governing mechanical stress-induced activation of L-type calcium channel activity are ...
    • Espinoza Calvo, Cristian Alejandro (Universidad de Chile, 2017)
      Introducción: La muerte de los cardiomiocitos induce la pérdida de función del corazón y el desarrollo de diferentes patologías, sin embargo, se desconoce a cabalidad los mecanismos implicados. La policistina-1 (PC1) es ...
    • Wang, Zhao V.; Deng, Yingfeng; Gao, Ningguo; Pedrozo Cibils, Zully; Li, Dan L.; Morales, Cyndi R.; Criollo Céspedes, Alfredo; Luo, Xiang; Tan, Wei; Jiang, Nan; Lehrman, Mark A.; Rothermel, Beverly A.; Lee, Ann Hwee; Lavandero González, Sergio; Mammen, Pradeep P .A.; Ferdous, Anwarul; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A. (Elsevier, 2014-03-13)
      The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the ...