Browsing by Author "Rosemblatt Silber, Mario César"
Now showing items 1-20 of 41
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Gamboa Garrido, María Cecilia (Universisdad de Chile, 2005)Las proteínas CBF pertenecen a una pequeña familia de factores de transcripci6n que juegan un papel importante en la capacidad que tienen las plantas de tolerar distintos tipos de estrés abiótico. Se ha demostrado que ...
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Alemtuzumab Induction in Kidney Transplantation: Clinical Results and Impact on T-Regulatory Cells Morales Peña, José; Bono Merino, María Rosa; Fierro, A.; Iñiguez, R.; Zehnder, C.; Rosemblatt Silber, Mario César; Calabran, L.; Herzog, C.; Benavente, D.; Aguiló, J.; Pefaur, J.; Alba, A.; Ferrario, M.; Simon, W.; Contreras, L.; Buckel González, Erwin (ELSEVIER SCIENCE INC, 2008-11)Alemtuzumab (ALT), a humanized monoclonal anti-CD52 antibody, was introduced in solid organ transplantation as an induction agent. ALT associated with anticalcineurins has provided a low incidence of acute rejection ...
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Benson, Micah J.; Pino-Lagos, Karina; Rosemblatt Silber, Mario César; Noelle, Randolph J. (ROCKEFELLER UNIV PRESS, 2007-06-25)We demonstrate that all-trans retinoic acid (RA) induces FoxP3 adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype ( 4 7 CC chemokine receptor 9 ) and the capacity to home to the lamina ...
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Benson, Micah J.; Pino, Karina; Rosemblatt Silber, Mario César; Noelle, Randolph J. (2007)We demonstrate that all-trans retinoic acid (RA) induces Ill adaptive T regulatory cells (A-Tregs) to acquire a gut-homing phenotype (alpha 4 beta 7(+) CC chemokine receptor 9(+)) and the capacity to home to the lamina ...
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Ruiz, Paulina; Maldonado, Paula; Hidalgo, Yessia; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Frontiers Media, 2015)The induction of donor-specific transplant tolerance is one of the main goals of modern immunology. Establishment of a mixed chimerism state in the transplant recipient has proven to be a suitable strategy for the induction ...
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Moore, Carolina; Tejón, Gabriela; Fuentes, Camila; Hidalgo, Yessia; Bono Merino, María Rosa; Maldonado, Paula; Fernández, Ricardo; Wood, Kathryn; Fierro, Juan; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bushell, Andrew (Wiley-Blackwell, 2015)CD4+CD25+Foxp3+ regulatory T (Treg) cells mediate immunological self-tolerance and suppress immune responses. Retinoic acid (RA), a natural metabolite of vitamin A, has been reported to enhance the differentiation of ...
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Lennon Duménil, Ana María; Bakker, Arnold H.; Maehr, René; Fiebiger, Edda; Overkleeft, Herman S.; Rosemblatt Silber, Mario César; Ploegh, Hidde L.; Lagaudrière-Gesbert, Cécile (2002)Here, we describe a new approach designed to monitor the proteolytic activity of maturing phagosomes in live antigen-presenting cells. We find that an ingested particle sequentially encounters distinct protease activities ...
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Girardi Lavín, Cristóbal. (Universisdad de Chile, 2005)La patología del enrollamiento clorotico de la hoja de vid (GLRaV) es la virosis de vides mas difundida en el mundo y causante de importantes perdidas en el sector vitícola. Hasta ahora se han reportado nueve variantes ...
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Bono Merino, María Rosa; Simon, Valeska; Rosemblatt Silber, Mario César (1989)It has been established that early events in lymphocyte activation involve a rise in intracellular Ca++ as well as changes in the flux of other ions. Although a Ca++ channel has been postulated to participate in the early ...
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Bono Merino, María Rosa; Fernández, Dominique; Flores Santibáñez, Felipe; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Elsevietr, 2015)Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
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Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Farías, Paula; Vargas, Leonardo; Simon Zegers, María Valeska; Cárdenas, César; Lladser, Álvaro; Salazar Onfray, Flavio Andrés; Elorza, Álvaro A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
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Flores Santibáñez, Felipe; Fernández, Dominique; Meza, Daniel; Tejón, Gabriela; Vargas, Leonardo; Varela Nallar, Lorena; Arredondo, Sebastián; Guixé Leguía, Victoria Cristina; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Wiley & Sons, 2015)The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
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Pino, Karina; Michea, Paula; Sauma Mahaluf, Daniela; Alba, Andrea; Morales, Jorge; Bono Merino, María Rosa; Fierro, Alberto; Rosemblatt Silber, Mario César (SOC BIOLGIA CHILE, 2010-08-12)One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
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Sauma Mahaluf, Daniela; Fierro, Alberto; Mora, J.R.; Lennon Duménil, Ana María; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Morales Peña, José (ELSEVIER, 2003-11)The mode of action of cyclosporine (CsA) has been ascribed to its capacity to inhibit IL-2 and IFNgamma production by T cells, two cytokines implicated in allograft rejection. Recently, it has been reported that upon ...
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Gleisner, Maria Alejandra; Reyes, Paz; Alfaro, Jennifer; Solanes, Paola; Simon, Valeska; Crisostomo, Natalia; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2013)Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increase in the percentage of autoreactive B and T lymphocytes. Since dendritic cells (DCs) are essential for B cell and T cell function, ...
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Jørgensen, Trine N.; Alfaro, Jennifer; Enríquez, Hilda L.; Jiang, Chao; Loo, William M.; Atencio, Stephanie; Bupp, Melanie R. Gubbels; Mailloux, Christina M.; Metzger, Troy; Flannery, Shannon; Rozzo, Stephen J.; Kotzin, Brian L.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Erickson, Loren D. (The American Association of Immunologists, Inc., 2010)Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss ofimmune ...
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Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Tucer, Suat; Saavedra Almarza, Juan Pablo; Hormann Cornejo, Pilar Leonor; Martínez, Brandon A.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Cekic, Caglar; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)Ecto-5 '-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is ...
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Michea, Paula; Vargas, Pablo; Donnadieu, Marie-Hélène; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Duménil, Guillaume; Soumelis, Vassili (WILEY-VCH Verlag GmbH & Co., 2013)Plasmacytoid pre-dendritic cells (pDCs) are specialized in responding to nucleic acids, and link innate with adaptive immunity. Although the response of pDCs to viruses is well established, whether pDCs can respond to ...
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Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2004)Research regarding the interactions between the endothelium and immune cells has undergone a significant expansion during the past decade. Major shifts of emphasis have been the norm, from the production of a detail catalog ...
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Elgueta, Raúl; Tobar, Jaime A.; Shoji, Kenji F.; De Calisto, Jaime; Kalergis, Alexis M.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Sáez, Juan C. (AMER ASSOC IMMUNOLOGISTS, 2009-04-30)The acquired immune response begins with Ag presentation by dendritic cells (DCs) to naive T cells in a heterocellular cell-cell contact-dependent process. Although both DCs and T cells are known to express connexin43, a ...