Browsing by Author "Rubilar, Paulina S."
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Soto Rifo, Ricardo; Rubilar, Paulina S.; Ohlmann, Théophile (Oxford University Press, 2013)Here, we show a novel molecular mechanism promoted by the DEAD-box RNA helicase DDX3 for translation of the HIV-1 genomic RNA. This occurs through the adenosine triphosphate-dependent formation of a translation initiation ...
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Fröhlich, Alvaro; Rojas Araya, Bárbara; Pereira Montecinos, Camila; Dellarossa, Alessandra; Toro Ascuy, Daniela; Prades Pérez, Yara; García de Gracia, Francisco; Garcés Alday, Andrea; Rubilar, Paulina S.; Valiente Echeverría, Fernando; Ohlmann, Théophile; Soto Rifo, Ricardo (2016)DEAD-box RNA helicase DDX3 is a host factor essential for HIV-1 replication and thus, a potential target for novel therapies aimed to overcome viral resistance. Previous studies have shown that DDX3 promotes nuclear ...
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Soto Rifo, Ricardo; Valiente Echeverría, Fernando Andrés; Rubilar, Paulina S.; Garcia-de-Gracia, Francisco; Ricci, Emiliano P.; Limousin, Taran; Décimo, Didier; Mouland, Andrew J.; Ohlmann, Théophile (2014)During the post-transcriptional events of the HIV-2 replication cycle, the full-length unspliced genomic RNA (gRNA) is first used as an mRNA to synthesize Gag and Gag-Pol proteins and then packaged into progeny virions. ...